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Randomized controlled trial of magnesium sulfate in women at risk of preterm delivery—neonatal cardiovascular effects

Journal of Perinatology volume 32, pages 665–670 (2012)Cite this article

Subjects

Abstract

Objective:

Use of antenatal magnesium sulfate (MgSO4) may reduce cerebral palsy in infants born very preterm. Low systemic blood flow in the first day in very preterm infants has been associated with cerebral injury and adverse motor outcome. The aim was to determine the effect of MgSO4 on systemic blood flow in preterm infants.

Study Design:

Randomized trial of MgSO4 versus saline placebo given to mothers at risk of delivery before 30 weeks gestation. Echocardiographic monitoring performed at 3 to 5, 10 to 12 and 24 h.

Result:

A total of 48 infants were exposed to MgSO4 and 39 to placebo. Infants exposed to MgSO4 were significantly more likely to receive volume expansion (42% versus 21%). Inotrope use did not differ significantly (40% versus 26%). There was no significant difference in mean lowest superior vena cava (SVC) flow or right ventricular output (RVO), or incidence of low SVC flow or RVO in the first 24 h. Infants exposed to MgSO4 had a significantly higher heart rate and were more likely to have low SVC flow at 10 to 12 h but not other times.

Conclusion:

Antenatal MgSO4 produced no consistent cardiovascular effects in the infant in the first 24 h. There is no evidence from this study to suggest the mechanism by which antenatal MgSO4 prevents cerebral palsy is through a cardiovascular effect in the newborn.

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Acknowledgements

We acknowledge the North Shore Heart Research Foundation for supporting this study, and the Australasian Collaborative Trial of Magnesium Sulphate collaborators for agreeing to this nested study.

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Authors and Affiliations

  1. Department of Neonatal Medicine, Royal North Shore Hospital, Sydney, Australia

    M Paradisis & M Kluckow

  2. Discipline Obstetrics, Gynaecology and Neonatology, University of Sydney, Sydney, Australia

    M Paradisis, D A Osborn, N Evans & M Kluckow

  3. RPA Newborn Care, RPAH Hospital, Sydney, Australia

    D A Osborn & N Evans

Authors
  1. M Paradisis
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  2. D A Osborn
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  3. N Evans
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  4. M Kluckow
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Correspondence to D A Osborn.

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The authors declare no conflict of interest.

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Paradisis, M., Osborn, D., Evans, N. et al. Randomized controlled trial of magnesium sulfate in women at risk of preterm delivery—neonatal cardiovascular effects. J Perinatol 32, 665–670 (2012). https://doi.org/10.1038/jp.2011.168

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