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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Monozygotic twins discordant for trisomy 13: counselling and management issues

Journal of Perinatology volume 32, pages 639–641 (2012)Cite this article

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Abstract

The diagnosis and management of a heterokaryotypic monochorionic pregnancy, in which one of twins had trisomy 13, is presented. Monozygosity and discordant karyotypes were confirmed by amniocentesis of both the sacs. Radiofrequency ablation of the trisomic twin was successfully performed at 18-weeks gestation and the pregnancy ended at term with the birth of a healthy girl who remains well on follow-up at 12 months of age. We reiterate the importance of early amniocentesis of both the sacs in the presence of discordant fetal abnormalities and consideration of selective fetal termination to optimise the outcome of heterokaryotypic monochorionic twin pregnancies.

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Acknowledgements

We thank Dr Karen Carpenter, Department of Cytogenetics, Nottingham City Hospital, for the Quantitative Fluorescent-PCR analysis.

Patient consent has been obtained for the publication of this manuscript.

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Authors and Affiliations

  1. Department of Clinical Genetics, Nottingham City Hospital, Nottingham, UK

    A Dixit, G Tanteles & A Sarkar

  2. Department of Cytogenetics, Nottingham City Hospital, Nottingham, UK

    K Ocraft

  3. Department of Maternal and Fetal Medicine, Nottingham City Hospital, Nottingham, UK

    A McEwan

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  1. A Dixit
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  2. G Tanteles
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  3. K Ocraft
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  4. A McEwan
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  5. A Sarkar
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Correspondence to A Sarkar.

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The authors declare no conflict of interest.

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Dixit, A., Tanteles, G., Ocraft, K. et al. Monozygotic twins discordant for trisomy 13: counselling and management issues. J Perinatol 32, 639–641 (2012). https://doi.org/10.1038/jp.2011.145

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