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Impact of metabolic syndrome components on incident stroke subtypes: a Chinese cohort study

Journal of Human Hypertension volume 28, pages 689–693 (2014)Cite this article

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Abstract

Limited evidence is available on the risk differences in the development of stroke subtypes in relation to particular clustering patterns of the metabolic syndrome (MetS) components. A follow-up study of a Chinese cohort involving 10 292 individuals was performed to assess the roles of cluster patterns of the MetS components in the prediction of incident stroke subtypes. During follow-up, there were 161 incident cases of ischemic strokes and 41 incident cases of hemorrhagic strokes. Among MetS components, only the hypertensive trait was associated with significantly elevated risks of both ischemic and hemorrhagic strokes. Furthermore, MetS with hypertension as components was associated with increased risk of ischemic and hemorrhagic strokes (adjusted hazards ratio (95% confidence interval) was 2.96 (1.94–4.50) and 2.93 (1.25–6.90), respectively) as compared with those who had neither hypertension nor MetS. Notably, as the number of the MetS components increased, the risk of ischemic stroke significantly and dose-dependently increased. This implies a cumulative effect of MetS components in elevating the risk of ischemic stroke. These findings suggest that MetS comprises heterogenous clusters with respect to the risk of developing the subtype of stroke.

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Acknowledgements

The authors thank the Bureau of Health Promotion, Department of Health for administrative support and nurses at study areas for data collection. Sources of funding: This study was supported by a grant from the Bureau of Health Promotion, Department of Health (DOH-95-HP-2103), Executive Yuan, Taiwan, Republic of China.

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The sponsor had no role in study design, collection, analysis and interpretation of data; writing the report and the decision to submit the report for publication.

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Authors and Affiliations

  1. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City, Taiwan, Republic of China

    Y-C Chen & Y-C Chou

  2. Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, Republic of China

    C-A Sun

  3. Department of Health Business Administration, Meiho University, Pingtung, Taiwan, Republic of China

    T Yang

  4. Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan, Republic of China

    C-H Chu

  5. School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei City, Taiwan, Republic of China

    C-H Bai

  6. Genomics Research Center, Academia Sinica, Taipei City, Taiwan, Republic of China

    S-L You

  7. School of Public Health, National Defense Medical Center, Taipei City, Taiwan, Republic of China

    S-L You & Y-C Chou

  8. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, Republic of China

    L-C Hwang

  9. Digestive Disease Center, Changhua Show-Chwan Memorial Hospital, Changhua County, Taiwan, Republic of China

    C-H Chen

  10. Department of Neurology, Chang Bing Show-Chwan Memorial Hospital, Changhua County, Taiwan, Republic of China

    C-Y Wei

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  1. Y-C Chen
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Correspondence to Y-C Chou.

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Chen, YC., Sun, CA., Yang, T. et al. Impact of metabolic syndrome components on incident stroke subtypes: a Chinese cohort study. J Hum Hypertens 28, 689–693 (2014). https://doi.org/10.1038/jhh.2013.152

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