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Adaptation of human adipose tissue to hypocaloric diet

International Journal of Obesity volume 37, pages 640–650 (2013)Cite this article

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Abstract

Hypocaloric diet is a key component of the weight-reducing treatment of obesity and obesity-related disorders. Hypocaloric diets and the associated weight reduction promote improvement of metabolic profile of obese individuals. Among the mechanisms that underlie this beneficial metabolic outcome, the diet-induced modifications of morphological and functional characteristics of human adipose tissue (AT) are believed to have an important role. Prospective studies of hypocaloric weight-reducing dietary intervention demonstrate effects on adipocyte metabolism, namely lipolysis and lipogenesis, and associated changes of the adipocyte size. The endocrine function of AT, which involves cytokine and adipokine production by adipocytes, as well as by cells of stromavascular fraction, is also regulated by dietary intervention. Related inflammatory status of AT is modulated also as a consequence of the changes in recruitment of immune cells, mainly macrophages, in AT. Here, we give an overview of metabolic and endocrine modifications in human AT induced by a variety of hypocaloric diets.

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Acknowledgements

Our work was supported by grants IGA NS 10519-3-2009 and IGA NT 11450-3-2010 of the Ministry of Health, Project MSM 0021620814 of the Ministry of Education of the Czech Republic, by INSERM, Région Midi-Pyrénées and by Integrated Project HEPADIP (www.hepadip.org), Contract No. LSHM-CT-2005-018734 and Collaborative Project ADAPT (www.adapt-eu.net), Contract No. HEALTH-F2-2008-2011 00).

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  1. Department of Sport Medicine, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    L Rossmeislová, L Mališová, J Kračmerová & V Štich

  2. Franco-Czech Laboratory of Clinical Research on Obesity, Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    L Rossmeislová, L Mališová, J Kračmerová & V Štich

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Rossmeislová, L., Mališová, L., Kračmerová, J. et al. Adaptation of human adipose tissue to hypocaloric diet. Int J Obes 37, 640–650 (2013). https://doi.org/10.1038/ijo.2012.80

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