Download the Nature Podcast 1 May 2024
In this episode:
00:46 Using genomics to explain geographical differences in cancer risk
The risk of developing cancer can vary hugely depending on geographical region, but it’s not exactly clear why. To get a better idea, a team has compared the genomes of kidney cancers taken from people around the globe. They reveal a link between geographical locations and specific genetic mutations, suggesting that there are as-yet unknown environmental or chemical exposures in different locations. They hope this work will inform public health efforts to identify and reduce potential causes of cancer.
Research Article: Senkin et al.
News and Views: Genomics reveal unknown mutation-promoting agents at global sites
07:46 Research Highlights
Research reveals that the extinct ‘sabre-toothed salmon’ actually had tusks, and a common fungus that can clean up both heavy-metal and organic pollutants.
Research Highlight: This giant extinct salmon had tusks like a warthog
Research Highlight: Garden-variety fungus is an expert at environmental clean-ups
09:55 How disrupting a male mouse’s microbiome affects its offspring
Disruption of the gut microbiota has been linked to issues with multiple organs. Now a team shows disruption can even affect offspring. Male mice given antibiotics targeting gut microbes showed changes to their testes and sperm, which led to their offspring having a higher probability of severe growth issues and premature death. Although it’s unknown whether a similar effect would be seen in humans, it suggests that factors other than genetics play a role in intergenerational disease susceptibility.
Research article: Argaw-Denboba et al.
News and Views: Dad’s gut microbes matter for pregnancy health and baby’s growth
17:23 Briefing Chat
An updated atlas of the Moon that was a decade in the making, and using AI to design new gene-editing systems.
Nature News: China's Moon atlas is the most detailed ever made
Nature News: ‘ChatGPT for CRISPR’ creates new gene-editing tools
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Why are so many young people getting cancer? What the data say
Location matters for insulin-producing cells
CRISPR might be the banana’s only hope against a deadly fungus
Japanese Moon-lander unexpectedly survives the lunar night
How to supercharge cancer-fighting cells: give them stem cell skills
What time is it on the Moon? Scientists are working that out
‘Treasure trove’ of new CRISPR systems holds promise for genome editing
Is ChatGPT making scientists hyper-productive? The highs and lows of using AI
The geography of climate governs biodiversity
