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Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological processes essential for the cells functions and maintenance.
Wu et al. show that prosurvival BCL-2 proteins disrupt SUFU repression of GLI activity, leading to GLI target gene expression. BH3 mimetics disable GLI transcriptional activity driven by HH pathway mutations.
The 3.8-Å cryo-EM structure of the Saccharomyces cerevisiae small-subunit processome in a state that precedes pre-rRNA cleavage at site A1 provides an essentially complete near-atomic model of this assembly.
A highly photostable RNA mimic of red fluorescent protein, Corn, was designed and used to image RNA polymerase III transcription. Quantitative imaging of Corn-tagged transcripts revealed transcription dynamics in live cells following mTOR inhibition.
It remains unknown how the central metabolite acetyl-CoA affects histone acetylation in plants. Chen et al. now show that cytosolic acetyl-CoA promotes histone acetylation predominantly at H3K27 in Arabidopsis.
The 2017 Albert Lasker Basic Medical Research Award was awarded to Michael N. Hall (Biozentrum, University of Basel, Switzerland) “for discoveries concerning the nutrient-activated TOR proteins and their central role in the metabolic control of cell growth”.