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Histocompatibility and Donor Selection Issues

UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation

Bone Marrow Transplantation volume 51, pages 79–82 (2016)Cite this article

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Abstract

Minor histocompatibility Ags (mHags) have been implicated in the pathogenesis of GVHD after allogeneic hematopoietic stem cell transplantation (HSCT). Uridine diphospho-glucuronosyltransferase 2B17 (UGT2B17) gene deletion may act as a mHag and its association with acute GVHD (aGVHD) has been described. We retrospectively studied the clinical impact of a UGT2B17 mismatch in a cohort of 1127 patients receiving a HSCT from an HLA-identical sibling donor. UGT2B17 mismatch was present in 69 cases (6.1%). Incidence of severe aGVHD was higher in the UGT2B17 mismatched pairs (22.7% vs 14.6%), but this difference was not statistically significant (P: 0.098). We did not detect differences in chronic GVHD, overall survival, relapse-free survival, transplant-related mortality or relapse. Nevertheless, when we analyzed only those patients receiving grafts from a male donor (616 cases), aGVHD was significantly higher in the UGT2B17 mismatched group (25.1% vs 12.8%; P: 0.005) and this association was confirmed by the multivariate analysis (P: 0.043; hazard ratio: 2.16, 95% confidence interval: 1.03–4.57). Overall survival was worse for patients mismatched for UGT2B17 (P: 0.005). We conclude that UGT2B17 mismatch has a negative clinical impact in allogeneic HSCT from HLA-identical sibling donors only when a male donor is used. These results should be confirmed by other studies.

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Acknowledgements

This work has been partially financed by grants PI11/01690 and PI14/01646 from the Instituto de Salud Carlos III, co-financed by FEDER (Fondo Europeo de desarrollo regional) and by grant MTV3/120210 from Fundació Marató TV3.

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Authors and Affiliations

  1. Clinical Hematology Department, Institut Català d’Oncologia, IDIBGi, Girona, Spain

    N Santos, R Rodríguez-Romanos & D Gallardo

  2. Hematology Department, Hospital Morales Meseguer, Murcia, Spain

    J B Nieto

  3. Hematology Department, Hospital Gregorio Marañón, Madrid, Spain

    I Buño & E Buces

  4. Hematology Department, Hospital Universitario Central de Asturias, Oviedo, Spain

    C Vallejo

  5. Hematology Department, Hospital Carlos Haya, Málaga, Spain

    A Jiménez-Velasco

  6. Hematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    S Brunet

  7. Hematology Department, Hospital Ramón y Cajal, Madrid, Spain

    J López-Jiménez

  8. Hematology Department, Hospital Universitario, Salamanca, Spain

    M González

  9. Institut Català d’Oncologia, Badalona, Spain

    C Ferrá

  10. Hematology Department, Hospital Son Espases, Palma de Mallorca, Spain

    A Sampol

  11. Hematology Department, Hospital La Princesa, Madrid, Spain

    R de la Cámara

  12. Hematology Department, Hospital Clínic, Barcelona, Spain

    C Martínez

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  1. N Santos
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  14. C Martínez
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  15. D Gallardo
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on behalf of the GvHD/Immunotherapy Working Party of the Spanish Group of Hematopoietic Transplant (GETH)

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Correspondence to D Gallardo.

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The authors declare no conflict of interest.

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Santos, N., Rodríguez-Romanos, R., Nieto, J. et al. UGT2B17 minor histocompatibility mismatch and clinical outcome after HLA-identical sibling donor stem cell transplantation. Bone Marrow Transplant 51, 79–82 (2016). https://doi.org/10.1038/bmt.2015.207

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