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Haploidentical transplantation in patients with acquired aplastic anemia

Bone Marrow Transplantation volume 48, pages 183–185 (2013)Cite this article

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Abstract

Haploidentical SCT (haplo-SCT) has been considered a therapeutic option in patients with acquired severe aplastic anemia (SAA) failing at least one course of immune suppressive therapy with antithymocyte globulin and lacking an HLA-matched related or unrelated donor. The platforms of both ex vivo T-cell-depleted and unmanipulated grafts have been explored in children and adults. Overall, the primary objective of a stable haploidentical hematopoietic engraftment with a low rate of GVHD is unmet in a significant proportion of patients undergoing haplo-SCT for SAA. Haploidentical transplants for refractory SAA should be performed in a specialist center with major experience in hematopoietic SCT procedures and preferably performed within the framework of a local clinical protocol designed specifically to address the prevention of graft rejection and GVHD.

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Authors and Affiliations

  1. Hematology and BMT Unit, EBMT CIC 813, San Raffaele Scientific Institute, Milano, Italy

    F Ciceri & M T Lupo-Stanghellini

  2. Department of Pediatrics, Hematology and BMT Unit, EBMT CIC 203, Leiden University Medical Center, Leiden, The Netherlands

    E T Korthof

  3. Sanquin-LUMC Jon J van Rood Center for Clinical Transfusion Research, Leiden, The Netherlands

    E T Korthof

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  1. F Ciceri
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  2. M T Lupo-Stanghellini
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Correspondence to F Ciceri.

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Ciceri, F., Lupo-Stanghellini, M., Korthof, E. et al. Haploidentical transplantation in patients with acquired aplastic anemia. Bone Marrow Transplant 48, 183–185 (2013). https://doi.org/10.1038/bmt.2012.231

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