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Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT

Bone Marrow Transplantation volume 48, pages 737–739 (2013)Cite this article

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Late-onset hemorrhagic cystitis (HC) is one of the most troublesome complications in patients undergoing allogeneic hematopoietic SCT (HSCT). As adenovirus serotype 11 (AdV11) with striking tropism for the urinary system is a pathogen predominantly responsible for late-onset HC after allogeneic HSCT in Japan,1, 2 it is important to assess the risk of AdV-HC and to make a rapid diagnosis of HC for early intervention.

As seven of eight non-AdV-HC patients had significant high urine BKV load between 4.3 × 108 and 1.7 × 1010 copies/mL (Figure 1c), most of the non-AdV-HC was considered to be BKV-associated HC. Among seven AdV-HC patients, three patients had concomitant BKV infections because of over a diagnostic viral load in urine (4.2 × 107 to 7.2 × 109 copies/mL) according to the criteria described by Cesaro et al.7 The serum BKV load did not influence the development of HC. Therefore, BKV might be an alternative main cause of HC in Japan.

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Acknowledgements

YN was supported in this work by the Mother and Child Health Foundation (Osaka, Japan). We thank Dr Ritsuro Suzuki for his helpful advice.

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Authors and Affiliations

  1. Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan

    Y Nakazawa, S Saito, R Yanagisawa & K Koike

  2. Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan

    T Suzuki

  3. Department of Hematology, Shinshu University School of Medicine, Matsumoto, Japan

    T Ito & F Ishida

  4. Division of Hematology and Oncology, Children’s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    H Muramatsu, K Matsumoto & K Kato

  5. Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Japan

    H Ishida

  6. Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    K Umeda, S Adachi & T Nakahata

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  1. Y Nakazawa
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Correspondence to Y Nakazawa.

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Nakazawa, Y., Saito, S., Yanagisawa, R. et al. Recipient seropositivity for adenovirus type 11 (AdV11) is a highly predictive factor for the development of AdV11-induced hemorrhagic cystitis after allogeneic hematopoietic SCT. Bone Marrow Transplant 48, 737–739 (2013). https://doi.org/10.1038/bmt.2012.206

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