The discovery that the gene SRY on the mammalian Y chromosome drives testis development marked a turning point in the decades-long quest to understand the genetic underpinnings and evolution of sex determination.
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Graves, J. Twenty-five years of the sex-determining gene. Nature 528, 343–344 (2015). https://doi.org/10.1038/528343a
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DOI: https://doi.org/10.1038/528343a
