Volume 43 Issue 6, June 2022

Schematic diagram showing how metformin promotes SCI (spinal cord injury) recovery. After SCI, metformin treatment not only reverses the SCI-induced blockade of autophagic flux in microglial cells, but also promotes the transformation of microglial cells from M1 to M2 phenotype polarization, subsequently enhancing the myelin debris clearance, which consequently promotes myelin preservation and nerve repair following SCI.

Review Article

Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy

Qing Li
Ming Xiang
Review Article 24 Sept 2021
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Article

Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction

Ruo-bing Guo
Yin-feng Dong
Xiu-lan Sun
Article 25 Oct 2021
Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury

Yan-qing Wu
Jun Xiong
Jian Xiao
Article 03 Sept 2021
Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion

Yuan-yuan Wei
Yan Ma
Jing-gen Liu
Article 07 Sept 2021
LncRNA-6395 promotes myocardial ischemia-reperfusion injury in mice through increasing p53 pathway

Lin-feng Zhan
Qi Zhang
Ming-yu Zhang
Article 07 Sept 2021
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism

Fan Qiu
Yi Yuan
Ling Gao
Article 14 Sept 2021
Antiatherosclerotic effect of dehydrocorydaline on ApoE^−/− mice: inhibition of macrophage inflammation

Bin Wen
Yuan-ye Dang
Xiao-yan Dai
Article Open Access 22 Sept 2021
Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

Xiao Guan
Guo-rong Dan
Xiao-hui Li
Article 30 Sept 2021
Small molecule compound M12 reduces vascular permeability in obese mice via blocking endothelial TRPV4–Nox2 interaction

Meng-ru Gao
Peng Zhang
Xin Ma
Article 15 Oct 2021
All-trans retinoic acid impairs glucose-stimulated insulin secretion by activating the RXR/SREBP-1c/UCP2 pathway

Han-yu Yang
Ming Liu
Li Liu
Article 20 Aug 2021
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors

Yu-zhe Wang
De-hua Yang
Ming-wei Wang
Article 26 Aug 2021
Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids

Min Liu
Yi Liu
Hui Wang
Article 25 Oct 2021
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway

Yi-kuan Wu
Zheng-nan Ren
Qi-xiao Zhai
Article 15 Oct 2021
IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver

Li-na Zhao
Hong-feng Yuan
Xiao-dong Zhang
Article 08 Sept 2021
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s

Yan-yang Li
Xiao-jing Wang
Xia Luo
Article 20 Oct 2021
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays

Yu Zhang
Lei Xu
Long-Tai Zheng
Article 24 Aug 2021
Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells

Li-jun Du
Yu-xiang Feng
Yun Zhang
Article Open Access 22 Sept 2021
GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib

Le-ying Chen
Qing You
Shi-yi Zhang
Article 22 Sept 2021
Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling

Yue-qiang Chen
Hai-yan Song
Xiang-hui Han
Article 23 Aug 2021
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment

Lei Wang
Lin Zhao
Xiu-li Guo
Article 30 Aug 2021
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells

Yu-chen Xiang
Peng Peng
Ying Liu
Article 14 Sept 2021
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming

Ping Wang
Jin-mei Jin
Xiao-jun Wu
Article 30 Aug 2021
Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction

Hai-yan Wang
Pian Yu
Yan Cheng
Article Open Access 29 Sept 2021
Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening

Xue-ping Hu
Liu Yang
Ting-jun Hou
Article 19 Oct 2021

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Correction

Author Correction: Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling

Yan-zi Yang
Xiao-juan Zhao
Ling-dong Kong
Correction 07 Sept 2021
Author Correction: Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling

Cheng-gui Wang
Yi-ting Lou
Cong Mao
Correction 15 Sept 2021
Author Correction: Inactivation of TSC1 promotes epithelial–mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy

Qian Lu
Yi-bing Chen
Xiao-xing Yin
Correction 13 Oct 2021

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Retraction

Retraction Note to: Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway

Mei Han
Hui Gao
Zhi-wu Han
Retraction 07 Sept 2021
Retraction Note: Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation

Hui Gao
Ming-quan Gao
Yan-tao Han
Retraction 07 Sept 2021

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Volume 43 Issue 6, June 2022

Review Article

Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy

Article

Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction

Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury

Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion

LncRNA-6395 promotes myocardial ischemia-reperfusion injury in mice through increasing p53 pathway

Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism

Antiatherosclerotic effect of dehydrocorydaline on ApoE^−/− mice: inhibition of macrophage inflammation

Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome

Small molecule compound M12 reduces vascular permeability in obese mice via blocking endothelial TRPV4–Nox2 interaction

All-trans retinoic acid impairs glucose-stimulated insulin secretion by activating the RXR/SREBP-1c/UCP2 pathway

Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors

Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids

Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway

IFN-α inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver

Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s

Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays

Norcantharidin ameliorates the development of murine lupus via inhibiting the generation of IL-17 producing cells

GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib

Osthole inhibits the migration and invasion of highly metastatic breast cancer cells by suppressing ITGα3/ITGβ5 signaling

Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment

Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells

Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming

Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction

Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening

Correction

Author Correction: Magnesium isoglycyrrhizinate ameliorates high fructose-induced liver fibrosis in rat by increasing miR-375-3p to suppress JAK2/STAT3 pathway and TGF-β1/Smad signaling

Author Correction: Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling

Author Correction: Inactivation of TSC1 promotes epithelial–mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy

Retraction

Retraction Note to: Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway

Retraction Note: Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation

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