Retraction to: Acta Pharmacologica Sinica https://doi.org/10.1038/aps.2017.154, published online 9 November 2017
The Editor-in-Chief has retracted this article. Concerns were raised regarding a number of figures, specifically:
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Figure 5C: two panels (SKI-II and SphK1 siRNA for Caki-2) appear to be nearly identical
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Figure 5C: the Caki-2 Control panel appears to be nearly identical to the ACHN SKI-II panel.
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Figure 5C: the Caki-2 panel for His (20 µmol/l) appears to be nearly identical to the ACHN panel for His+SKI-II.
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Figure 5C: the Caki-2 panel for His+SKI-II appears to be nearly identical to the ACHN panel for His-SphK1 siRN.
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Figure 5C appears to partially overlap with Figure 5G of [1].
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Figure 6C: the TUNEL/Control, TUNEL/His (40 mg/kg) panels and the p-JNK1/2/His (40 mg/kg panels appear to have been previously published as the TUNEL/Control, TUNEL/His (40 mg/kg) and cleaved PARP/His (40 mg/kg) panels of Figure 4C of [2].
The Editor-in-Chief therefore no longer has confidence in the reliability of the data reported in the article.
References
Pan X, Wang H, Tong D, Wang C, Sun L, Zhao C, et al. Physcion induces apoptosis in hepatocellular carcinoma by modulating miR-370. Am J Cancer Res. 2016;6:2919–31.
Gao MQ, Gao H, Han M, Liu KL, Peng JJ, Han YT. Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat. Am J Cancer Res. 2017;7:1501–14. (Retraction published Am J Cancer Res. 2020 Jun 01;10(6):1921).
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Gao, H., Gao, Mq., Peng, Jj. et al. Retraction Note: Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation. Acta Pharmacol Sin 43, 1622 (2022). https://doi.org/10.1038/s41401-021-00731-3
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DOI: https://doi.org/10.1038/s41401-021-00731-3
