Volume 43 Issue 7, July 2022
This work discovered that depletion of Clk1 significantly suppressed methamphetamine-induced reward behaviors in Clk1+/- mutation mice, which was accompanied by elevated expression of dopamine transporter (DAT). It was further demonstrated that HIF-1α-mediated change in iron homeostasis is involved in the Clk1 deficiency-altered DAT expression by interrupting its degradation.
