Transplant immunology articles within Nature Communications

Featured

• Article
  30 April 2024 | Open Access

  Primary prophylaxis with mTOR inhibitor enhances T cell effector function and prevents heart transplant rejection during talimogene laherparepvec therapy of squamous cell carcinoma

  Cutaneous squamous cell carcinoma is more frequent and more aggressive in the organ transplanted and represent a therapeutic challenge due to the ongoing transplantrelated immune suppression. Here, the authors present a case report of a patient whose T cell responses were successfully strengthened via primary prophylactic therapy with mammalian target of rapamycin inhibition and intra-lesion injection of the oncolytic herpesvirus T-VEC.

  • Victor Joo
  • , Karim Abdelhamid
  •  & Michel Obeid

• Article
  18 April 2024 | Open Access

  Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment

  Viral infection is a common risk for immune-compromised individuals, particularly pediatric patients receiving hematopoietic stem cell transplants. Here the authors report a phase II trial testing adoptive transfer of third party, virus-specific T cells on the feasibility, safety, clinical responses, as well as homeostasis of antiviral immunity in the recipients.

  • Michael D. Keller
  • , Patrick J. Hanley
  •  & Michael A. Pulsipher

• Article
  15 April 2024 | Open Access

  Donor regulatory T cells rapidly adapt to recipient tissues to control murine acute graft-versus-host disease

  Graft-versus-Host disease is a major complication after allogeneic bone marrow transplantation and is ameliorated by adoptively transferred donor regulatory T cells. Here, the authors apply transcriptomic and TCR profiling to assess regulatory T cell organ-specific adaptation in murine bone marrow transplantation models.

  • David J. Dittmar
  • , Franziska Pielmeier
  •  & Michael Rehli

• Article
  11 April 2024 | Open Access

  Spatiotemporal immune atlas of a clinical-grade gene-edited pig-to-human kidney xenotransplant

  Xenotransplantation in humans using pig organs could improve the transplant organ supply. Here the authors transplant pig kidneys into a brain-dead recipient and monitor the human immune cell response early after transplantation using spatial and single cell transcriptomics and show early myeloid cell infiltration.

  • Matthew D. Cheung
  • , Rebecca Asiimwe
  •  & Paige M. Porrett

• Article
  19 January 2024 | Open Access

  HLA class I peptide polymorphisms contribute to class II DQβ0603:DQα0103 antibody specificity

  Bead-based assays to assess the donor-specific antibody profile of solid organ transplant patients often produce discordant results relative to cell-based alternatives. In this study, the authors demonstrate that, for some MHC class-II-specific antibodies, discordance can be attributed to recognition of the MHC class-I-derived peptides bound to MHC class-II molecules.

  • N. Remi Shih
  • , Thoa Nong
  •  & Jar-How Lee

• Article
  25 October 2023 | Open Access

  Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization

  Intestinal ischemia/reperfusion (I/R) injury is a life-threatening problem in surgeries. Here, authors report that intestinal organoids transplantation attenuates intestinal I/R injury in mice through L-Malic acid-mediated M2 macrophage polarization.

  • Fang-Ling Zhang
  • , Zhen Hu
  •  & Ke-Xuan Liu

• Article
  22 September 2023 | Open Access

  Defining a TCF1-expressing progenitor allogeneic CD8⁺ T cell subset in acute graft-versus-host disease

  Graft-versus-host disease (GvHD) is mediated by activated T cells. Here the authors study mouse models of allogeneic and xenogeneic GvHD, and define T cell factor-1 (TCF1)⁺ and TCF1^- T cell subsets with distinct functions and differentiation pathways that participate in GvHD pathogenesis.

  • Solhwi Lee
  • , Kunhee Lee
  •  & Se Jin Im

• Article
  19 July 2023 | Open Access

  Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection

  Although long-term kidney allograft failure is broadly classified as T cell- or antibody-mediated, this dichotomy is not always apparent in all patients, highlighting the need for improved allograft tissue characterisation. Here, the authors use single-cell RNA sequencing and multiplex imaging for transcriptomic and spatial profiling of allograft tissue from patients experiencing different degrees of rejection severity.

  • Baptiste Lamarthée
  • , Jasper Callemeyn
  •  & Maarten Naesens

• Article
  24 May 2023 | Open Access

  A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells

  NLRP3 inflammasomes trigger release of IL-1 to promote tissue injury. Here, Li et al identify a ZFYVE21-Rubicon-RNF34 (ZRR) signaling complex localizing to endosomes and modulating complement-mediated inflammasome activity in vitro and in vivo.

  • Xue Li
  • , Quan Jiang
  •  & Dan Jane-wit

• Article
  21 April 2023 | Open Access

  Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver

  Normothermic machine perfusion (NMP) is a method of keeping transplant organs maintained closer to physiological conditions. Here the authors analyse the immune cell dynamics during NMP in human donor livers using scRNA sequencing as a way of assessing the effects of NMP upon the immune status of the organ.

  • T. Hautz
  • , S. Salcher
  •  & S. Schneeberger

• Article
  21 March 2023 | Open Access

  Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy

  Immune checkpoint inhibitors (ICI) may have unanticipated side effects in transplant recipients who subsequently develop tumors. Here the authors used single-cell sequencing to identify and characterize allogeneic reactive T cells that developed after an ICI course for melanoma in a transplant recipient.

  • Garrett S. Dunlap
  • , Daniel DiToro
  •  & Deepak A. Rao

• Article
  13 March 2023 | Open Access

  Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

  IL-2/anti-IL-2 antibody complexes have been shown to facilitate the process of graft acceptance in transplantation. Here the authors use a mouse allograft model to show that IL-2 complexes promote graft acceptance and formation of inducible lymphoid structures containing Treg cells in transplanted lungs.

  • Yoshito Yamada
  • , Tuan Thanh Nguyen
  •  & Onur Boyman

• Article
  08 February 2023 | Open Access

  Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

  Antigen-specific tolerance represents a promising strategy to treat type 1 diabetes and islet allograft rejection. Here, the authors deliver immune signals to lymph nodes to promote antigen-specific regulatory T cells and prevent disease in models of type 1 diabetes and allogenic islet transplantation.

  • Joshua M. Gammon
  • , Sean T. Carey
  •  & Christopher M. Jewell

• Article
  26 December 2022 | Open Access

  Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

  Islet transplantation for type 1 diabetes management is hindered by the life-long need for immunosuppressive medications. Here, the authors report an islet encapsulation device with local anti-rejection drug release that achieves long-term diabetes reversal in male rats and reduces drug-related toxicity.

  • Jesus Paez-Mayorga
  • , Jocelyn Nikita Campa-Carranza
  •  & Alessandro Grattoni

• Article
  30 November 2022 | Open Access

  HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation

  Acute graft versus host disease is a rare but deadly complication following liver transplantation. Author show here, upon screening a large cohort of liver transplanted patients and detailed immune phenotyping of samples from the 7 affected individuals and appropriate controls, that human T cell lymphotropic virus type I infection of donor immune cells appear to correlate with the occurrence of acute graft versus host disease.

  • Chuan Shen
  • , Yiyang Li
  •  & Qiang Xia

• Article
  11 October 2022 | Open Access

  Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

  Targeted nanoparticle delivery to sites of interest is important for targeted therapeutics. Here, the authors improve the targeting efficiency of antibodies on nanoparticles using a monobody adapter to correctly orientate the antibody to preserve targeting function and demonstrate application in targeting the vascular endothelium of human kidneys.

  • C. Albert
  • , L. Bracaglia
  •  & G. T. Tietjen

• Article
  30 June 2022 | Open Access

  Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing

  Host versus graft reaction is a major impediment to CAR-T cell immune therapy in allogeneic settings. Authors show here that CAR-T cells, engineered to be deficient in MHC I expression but to express the NK inhibitor HLA-E, are resistant to destruction by both T and NK cells of the host.

  • Sumin Jo
  • , Shipra Das
  •  & Julien Valton

• Article
  03 June 2022 | Open Access

  Ex vivo-expanded human CD19⁺TIM-1⁺ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis

  Human regulatory B (Breg) cells have been difficult to study due to their scarcity and heterogeneity. Here the authors expand human B cells to exert immunosuppressive function in vitro and in vivo, and to implicate the TIM-1/STAT3 axis for the regulation of their homoeostasis and function.

  • S. Shankar
  • , J. Stolp
  •  & K. J. Wood

• Article
  11 May 2022 | Open Access

  Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation

  Human cytomegalovirus is a major cause of morbidity and mortality in transplant patients and multiple immune cells types are critical during infection and reactivation. Here the authors assess the immune cell compartments of haematopoietic stem cell recipients in the early period post transplantation and identify key features of effector memory CD4⁺ T cells and mucosal associated invariant T cells in this context.

  • Lauren Stern
  • , Helen M. McGuire
  •  & Barry Slobedman

• Article
  08 November 2021 | Open Access

  Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

  Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.

  • Baptiste Lamarthée
  • , Armance Marchal
  •  & Julien Zuber

• Article
  15 September 2021 | Open Access

  C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

  Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.

  • Robin Schmitz
  • , Zachary W. Fitch
  •  & Stuart J. Knechtle

• Article
  16 July 2021 | Open Access

  Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection

  Intrarenal B cells are indicative of poor prognosis in human renal allografts. Here the authors use single cell RNA sequencing to examine how intrarenal B cells contribute to renal rejection and find a population of innate B cells reactive to renal-specific or inflammation-associated antigens.

  • Yuta Asano
  • , Joe Daccache
  •  & Marcus R. Clark

• Article
  06 July 2021 | Open Access

  Inflammatory monocytes promote pre-engraftment syndrome and tocilizumab can therapeutically limit pathology in patients

  Pre-engraftment syndrome is a major consideration during clinical application of unrelated cord blood transfusion and monocytes represent a critical cell type in immune-pathogenesis. Here the authors further establish the role of monocytes and GM-CSF in pre-engraftment syndrome and show clinical administration of tocilizumab limits pathology in pre-engraftment syndrome pathology in patients.

  • Linlin Jin
  • , Zimin Sun
  •  & Haiming Wei

• Article
  09 April 2021 | Open Access

  A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation

  Here, the authors combine 16 S rRNA sequencing, culture and bioinformatics to profile the microbiome in 234 serial bronchoalveolar lavage samples from 64 lung transplant recipients collected over 49-months and identify distinct compositional states, termed pneumotypes, linked to current health status, and establish a collection of primary lung bacterial isolates, LuMiCol.

  • Sudip Das
  • , Eric Bernasconi
  •  & Laurent P. Nicod

• Article
  09 March 2021 | Open Access

  Implication of TIGIT⁺ human memory B cells in immune regulation

  Regulatory B cells have been shown to play critical roles in the modulation of the immune system. Here, the authors implicate TIGIT expression in B cells with the process of immuno-regulation.

  • Md Mahmudul Hasan
  • , Sumi Sukumaran Nair
  •  & SangKon Oh

• Article
  27 August 2020 | Open Access

  Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

  Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.

  • Jasper Iske
  • , Midas Seyda
  •  & Stefan G. Tullius

• Article
  24 August 2020 | Open Access

  T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

  In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8⁺ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.

  • Meng Zhou
  • , Faruk Sacirbegovic
  •  & Warren D. Shlomchik

• Article
  03 February 2020 | Open Access

  Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

  Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppressive HSC defects can be reversed by administration of Stem Cell Growth Factor SCGFa.

  • Pradeep Ramalingam
  • , Michael G. Poulos
  •  & Jason M. Butler

• Article
  13 December 2019 | Open Access

  Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

  Graft versus host disease (GvHD) still hinders allogeneic hematopoietic stem cell transplantation. Here, the authors use metabolomics to analyze two cohorts of paired transplant recipients and donors, identifying significant differences in both host- and microbiota-derived metabolites.

  • David Michonneau
  • , Eleonora Latis
  •  & Gérard Socié

• Article
  06 September 2019 | Open Access

  Caspase-11 signaling enhances graft-versus-host disease

  An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the signals leading to caspase-11 activation in GvHD.

  • Yanyan Lu
  • , Ran Meng
  •  & Ben Lu

• Article
  02 August 2019 | Open Access

  Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

  Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular correlates of tolerance induction.

  • Amar Singh
  • , Sabarinathan Ramachandran
  •  & Bernhard J. Hering

• Article
  21 May 2019 | Open Access

  Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes

  The development of tissue-engineered vascular grafts heavily relies on the availability of large animal models that allow long-term assessment of graft patency. Here Itoh et al. propose a novel model of immunodeficient pigs that allows long-term accommodation of human cell-derived three-dimensional bioprinted vascular tubes.

  • Manabu Itoh
  • , Yosuke Mukae
  •  & Eiji Kobayashi

• Article
  23 April 2019 | Open Access

  Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing

  Adaptive immunity from both B and T cells critically controls the rejection or survival of transplanted organs. Here the authors show, by analyzing human B cell receptor repertoire in longitudinal studies of patients receiving kidney transplants, that repertoire diversity is positively associated with the incidence of kidney rejection.

  • Silvia Pineda
  • , Tara K. Sigdel
  •  & Minnie M. Sarwal

• Article
  25 March 2019 | Open Access

  Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

  Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.

  • Maddalena Noviello
  • , Francesco Manfredi
  •  & Chiara Bonini

• Article
  11 March 2019 | Open Access

  A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation

  Allograft can induces local chronic inflammation, but how this feeds back to regulating late immunity is still not clear. Here the authors show, by charactering B cell transcriptome landscape dynamic in human allografts and in mouse kidneys transitioning from acute to chronic injury, that late B cell activation is associated with renal dysfunction and inflammation.

  • Pietro E. Cippà
  • , Jing Liu
  •  & Andrew P. McMahon

• Article
  21 February 2019 | Open Access

  Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

  Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

  • Yue Gu
  • , Yee Hwa Wong
  •  & Paul A. MacAry

• Article
  06 February 2019 | Open Access

  Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation

  Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance without clear adverse effects or the need for chronic immune suppression.

  • Zhanzhuo Li
  • , Agnieszka Czechowicz
  •  & Philip M. Murphy

• Article
  06 February 2019 | Open Access

  Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

  Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the authors show that antibody-drug-conjugate to CD117, a HSC marker, allows specific and efficient preconditioning for HSC therapy.

  • Agnieszka Czechowicz
  • , Rahul Palchaudhuri
  •  & Derrick J. Rossi

• Article
  25 October 2018 | Open Access

  Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation

  Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV reservoir persists in multiple tissues early after transplantation.

  • Lucrezia Colonna
  • , Christopher W. Peterson
  •  & Leslie S. Kean

• Article
  10 September 2018 | Open Access

  Microbial metabolite sensor GPR43 controls severity of experimental GVHD

  The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.

  • Hideaki Fujiwara
  • , Melissa D. Docampo
  •  & Pavan Reddy

• Article
  28 August 2018 | Open Access

  March1-dependent modulation of donor MHC II on CD103⁺ dendritic cells mitigates alloimmunity

  Donor-derived dendritic cells (do-DC) in the graft can contribute to the induction of alloimmunity and tissue rejection, but how do-DC can be targeted for improving graft survival is unclear. Here the authors show that reducing MHC-II expression on do-DCs by DnaK pre-treatment can decrease the priming of alloimmunity and prolong graft survival in mouse models.

  • Thiago J. Borges
  • , Naoka Murakami
  •  & Cristina Bonorino

• Article
  20 July 2018 | Open Access

  TIGIT⁺ iTregs elicited by human regulatory macrophages control T cell immunity

  Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT⁺ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients.

  • Paloma Riquelme
  • , Jan Haarer
  •  & James A. Hutchinson

• Article
  04 December 2017 | Open Access

  TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut

  Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells

  • Andrea Romagnani
  • , Valentina Vettore
  •  & Susanna Zierler

• Article
  10 November 2017 | Open Access

  Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

  Rhesus macaques are not ideal for studying response to allogeneic hematopoietic stem cell transplant (allo-HSCT) owing to complex MHC genetics that prevent full MHC-matching. Here the authors show that inbred Mauritian-origin cynomolgus macaques are a superior preclinical model of allogeneic stem cell transplantation that mimics diverse clinical outcomes of human allo-HSCT.

  • Benjamin J. Burwitz
  • , Helen L. Wu
  •  & Jonah B. Sacha

• Article
  17 October 2017 | Open Access

  Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

  Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.

  • Ruishu Deng
  • , Christian Hurtz
  •  & Defu Zeng

• Article
  16 October 2017 | Open Access

  Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

  Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.

  • Mayuko Uehara
  • , Martina M. McGrath
  •  & Reza Abdi

• Article
  30 August 2017 | Open Access

  MHC matching improves engraftment of iPSC-derived neurons in non-human primates

  Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.

  • Asuka Morizane
  • , Tetsuhiro Kikuchi
  •  & Jun Takahashi

• Article
  21 August 2017 | Open Access

  Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells

  Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand T_reg cells, mitigating the disease in mice.

  • Satish Ranjan
  • , Alexander Goihl
  •  & Berend Isermann

• Article
  04 August 2017 | Open Access

  Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells

  The use of gene silencing techniques in the treatment of post-transplantation host rejection is not long lasting and can have systemic effects. Here, the authors utilize a nanocarrier for siRNA for treatment of arteries ex vivo prior to implantation subsequently attenuating immune reaction in vivo.

  • Jiajia Cui
  • , Lingfeng Qin
  •  & W. Mark Saltzman

• Article
  16 December 2016 | Open Access

  A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

  Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1⁺cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.

  • Deepak Tripathi
  • , Sambasivan Venkatasubramanian
  •  & Ramakrishna Vankayalapati