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Targeting EMT using low-dose Teniposide by downregulating ZEB2-driven activation of RNA polymerase I in breast cancer
- Brandon J. Metge
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A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
- Alaa Al Assi
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Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress
- Rony Takchi
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Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression
- Zhao Cui
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Metabolic remodeling by the PD-L1 inhibitor BMS-202 significantly inhibits cell malignancy in human glioblastoma
- Xueou Yang
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Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma
- Yan Qin Tan
- , Bowen Sun
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Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
- Buse Cevatemre
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Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control
- Daric J. Wible
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BACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia
- Min Feng
- , Bailing Zhang
- & Han Zhang
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CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
- Xin Fu
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Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer
- Qingyun Zhu
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New ruthenium-xanthoxylin complex eliminates colorectal cancer stem cells by targeting the heat shock protein 90 chaperone
- Luciano de S. Santos
- , Valdenizia R. Silva
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Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2
- Claudia Abbruzzese
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Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells
- Melina Vogt
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The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment
- J. Contenti
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RPL22L1, a novel candidate oncogene promotes temozolomide resistance by activating STAT3 in glioblastoma
- Yunping Chen
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Inhibition of PDGFRβ alleviates endothelial cell apoptotic injury caused by DRP-1 overexpression and mitochondria fusion failure after mitophagy
- Xiaohong An
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Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma
- Karolina Borankova
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A novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation
- Baijiao An
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Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice
- Jinyuan Wang
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miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication
- Teresa Fuertes
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HLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway
- Tao Han
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Vemurafenib inhibits necroptosis in normal and pathological conditions as a RIPK1 antagonist
- Mayu Sun
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Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1
- Huitong Bu
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Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer
- Soon Young Park
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BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice
- Monica Cattaneo
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Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
- Nannan Song
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FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer
- Mengmeng Wang
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Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma
- Tamara Bintener
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Review Article
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Exosome-based nanoimmunotherapy targeting TAMs, a promising strategy for glioma
- Hong Luo
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Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma
- Jiayang Cai
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Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients
- Peter Holicek
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Review Article
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Iron metabolism and ferroptosis in type 2 diabetes mellitus and complications: mechanisms and therapeutic opportunities
- Runyu Miao
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Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3/IL-33/ST2 axis
- Qing Ma
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Review Article
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Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis
- Mingyue Tan
- , Yunfei Yin
- & Hongxia Li
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Dasabuvir suppresses esophageal squamous cell carcinoma growth in vitro and in vivo through targeting ROCK1
- Xinning Liu
- , Yanan Jiang
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Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I
- Hao Wu
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Use of mouse primary epidermal organoids for USA300 infection modeling and drug screening
- Xiaorui Xie
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- & Li Liu
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The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest
- Wenpeng Zhao
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Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy
- Jingyu Ni
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Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH
- Su-Yeon Lee
- , Sanghwa Kim
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
- Natalia Maciejewska
- , Mateusz Olszewski
- & Nadia Zaffaroni
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Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
- Chunyang Yi
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Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors
- Yipu Fan
- , Yihan Zhang
- & Xiaodong Shu
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Article
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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
- Qianying Lv
- , Xinli Han
- & Hong Xu
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Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism
- Pengyun Li
- , Qiaohong Lin
- & Song Li
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Article
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Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
- Shidong Lv
- , Zeyu Wu
- & Qiang Wei
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GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL
- Filomena De Falco
- , Chiara Rompietti
- & Emanuela Rosati
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Article
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Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma
- Xiuqin Jia
- , Ming Xin
- & Jian Zhang
Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer