T cells articles within Nature

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• News | 05 May 2010

  Well-trained immune cells keep HIV in check

  Differences in T-cell development may explain why some infected people do not develop AIDS.

  • Alla Katsnelson

• News & Views | 01 April 2010

  Close encounters of the second type

  To combat intestinal worms, mammals rely on adaptive immune responses mediated by T cells. However, it seems that, initially, innate immune cells mimic T-cell activity, while T cells get ready for action.

  • Gérard Eberl

• Letter | 01 April 2010

  IL25 elicits a multipotent progenitor cell population that promotes T_H2 cytokine responses

  Several non-haematopoietic-cell-derived cytokines, including interleukin (IL)25, have been implicated in inducing T helper 2 (T_H2) cell-dependent inflammation, but their precise role has been unclear. Here, IL25 is shown to promote the accumulation of multipotent progenitor cells in gut-associated lymphoid tissue. These cells can give rise to macrophage or granulocyte lineages that promote the differentiation of T_H2 cells and contribute to protective immunity against helminth infections.

  • Steven A. Saenz
  • , Mark C. Siracusa
  •  & David Artis

• Letter | 01 April 2010

  IκBζ regulates T_H17 development by cooperating with ROR nuclear receptors

  Interleukin-17-producing helper T (T_H17) cells are a distinct T-cell subset characterized by its role in autoimmune disease. Here it is shown that the development of T_H17 cells requires the transcription factor IκBζ, as well as nuclear receptors of the ROR family. Mice lacking IκBζ have a defect in T_H17 development and are resistant to the induction of experimental autoimmune encephalomyelitis. The study points to some new potential molecular targets for drugs to treat autoimmune disease.

  • Kazuo Okamoto
  • , Yoshiko Iwai
  •  & Hiroshi Takayanagi

• Letter | 31 March 2010

  The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

  Quantification of the interaction of T-cell receptors with their peptide–MHC ligands in two–dimensional membranes is shown to yield larger dissociation rate constants than previous assays where one of the interacting partners was in solution.

  • Jun Huang
  • , Veronika I. Zarnitsyna
  •  & Cheng Zhu

• News & Views | 27 January 2010

  The expanding T_H2 universe

  T_H2 growth factors, which are involved in allergy and in defence against parasites, are produced by many different cell types, including a newly identified population found in fat-associated lymph clusters in the abdomen.

  • Warren Strober

• Letter | 13 January 2010

  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

  Immune homeostasis relies on tight control over the size of a population of regulatory T cells (T_reg) that can suppress over-exuberant immune responses. Cells commit to the T_reg lineage by upregulating the transcription factor Foxp3. Conserved non-coding DNA sequence elements at the Foxp3 locus are now shown to control the composition, size and maintenance of the T_reg cell population.

  • Ye Zheng
  • , Steven Josefowicz
  •  & Alexander Y. Rudensky