T cells articles within Nature

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• Article
  17 January 2024 | Open Access

  Autoreactive T cells target peripheral nerves in Guillain–Barré syndrome

  Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome, and these T cells are likely to contribute to disease pathophysiology.

  • L. Súkeníková
  • , A. Mallone
  •  & D. Latorre

• Article
  15 November 2023 | Open Access

  Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer

  Analyses of causal gene regulatory networks have identified key checkpoints mediating the progressive differentiation of CD8⁺ cytotoxic T cells, findings that have implications for anticancer immunotherapies such as adoptive cell therapy and immune checkpoint blockade.

  • Peipei Zhou
  • , Hao Shi
  •  & Hongbo Chi

• Article | 20 September 2023

  Reductive carboxylation epigenetically instructs T cell differentiation

  Reductive carboxylation of glutamine by isocitrate dehydrogenase 2 (IDH2) has a role in determining the fate of T cells, and inhibiting this enzyme promotes the differentiation of memory T cells.

  • Alison Jaccard
  • , Tania Wyss
  •  & Mathias Wenes

• Article | 20 September 2023

  The β₁-adrenergic receptor links sympathetic nerves to T cell exhaustion

  Stress-associated catecholamines promote CD8⁺ T cell exhaustion through the β₁-adrenergic receptor, and blocking β-adrenergic signalling may help restore anti-tumour functions.

  • Anna-Maria Globig
  • , Steven Zhao
  •  & Susan M. Kaech

• Article | 30 August 2023

  CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

  A combination of genome-wide CRISPR screens in target cancer cells identifies pathways that regulate γδ T cell killing and BTN3A cell surface expression.

  • Murad R. Mamedov
  • , Shane Vedova
  •  & Alexander Marson

• Article
  19 July 2023 | Open Access

  A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

  The human leukocyte antigen allele HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection due to pre-existing T cell immunity.

  • Danillo G. Augusto
  • , Lawton D. Murdolo
  •  & Jill A. Hollenbach

• Article
  17 May 2023 | Open Access

  Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma

  Tumour-infiltrating lymphocytes from glioblastoma can recognize bacterial and gut microbial peptides.

  • Reza Naghavian
  • , Wolfgang Faigle
  •  & Roland Martin

• Matters Arising | 01 February 2023

  GOT1 constrains T_H17 cell differentiation, while promoting iT_reg cell differentiation

  • Wei Xu
  • , Chirag H. Patel
  •  & Jonathan D. Powell

• Article
  11 January 2023 | Open Access

  γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

  γδ T cells contribute to the response to immune checkpoint blockade treatment in patients with HLA-class-I-negative DNA mismatch repair-deficient colon cancers. .

  • Natasja L. de Vries
  • , Joris van de Haar
  •  & Emile E. Voest

• Article | 28 September 2022

  PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program

  PD-1⁺TCF1⁺ stem-like CD8⁺ T cells—precursors of exhausted CD8⁺ T cells—are not fate-locked into the exhaustion program; their differentiation trajectory can be changed by IL-2 signals.

  • Masao Hashimoto
  • , Koichi Araki
  •  & Rafi Ahmed

• Article | 06 July 2022

  Immune tolerance of food is mediated by layers of CD4⁺ T cell dysfunction

  Immune tolerance to food is mediated by CD4⁺ T cells forming subsets of T helper cells lacking the capacity to trigger gut pathology but able to produce regulatory T cells that may suppress it.

  • Sung-Wook Hong
  • , Peter D. Krueger
  •  & Marc K. Jenkins

• Article | 22 June 2022

  cBAF complex components and MYC cooperate early in CD8⁺ T cell fate

  cBAF is a negative determinant of memory T cell fate and the manipulation of cBAF early in T cell differentiation can improve cancer immunotherapy.

  • Ao Guo
  • , Hongling Huang
  •  & Douglas R. Green

• Article | 11 May 2022

  Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

  A single-cell Poisson model is used to analyse eQTLs in memory T cells across continuous, dynamic cell states, revealing that the cell context is critical to understanding variation in eQTLs and their association with disease.

  • Aparna Nathan
  • , Samira Asgari
  •  & Soumya Raychaudhuri

• Article | 04 May 2022

  Landscape of helper and regulatory antitumour CD4⁺ T cells in melanoma

  A survey of the CD4⁺ T cells in human melanomas indicates that immune evasion is mediated through direct stimulation of neoantigen-specific tumour-reactive regulatory T cells by HLA class II-positive melanoma cells.

  • Giacomo Oliveira
  • , Kari Stromhaug
  •  & Catherine J. Wu

• Article | 20 April 2022

  Programme of self-reactive innate-like T cell-mediated cancer immunity

  A survey of T cell populations in human and mouse tumours identifies a population of cancer-sensing IL-15-activated αβ T cell receptor-positive FCER1G-expressing innate-like T cells with high cytotoxic potential.

  • Chun Chou
  • , Xian Zhang
  •  & Ming O. Li

• Article | 16 March 2022

  A genome-scale screen for synthetic drivers of T cell proliferation

  A genome-scale gain-of-function screen using overexpression of nearly 12,000 open reading frames (ORFs) identifies positive regulators of human T cell function and suggests that ORF-based screens could be applied clinically to improve T cell therapies.

  • Mateusz Legut
  • , Zoran Gajic
  •  & Neville E. Sanjana

• Article
  31 January 2022 | Open Access

  Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron

  Current vaccines induce broadly cross-reactive cellular immunity against SARS-CoV-2 variants, including Omicron, and provide protection against severe disease despite a substantially reduced neutralizing antibody response.

  • Jinyan Liu
  • , Abishek Chandrashekar
  •  & Dan H. Barouch

• Article | 18 November 2021

  CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

  CRISPR screening and protein–protein interaction networks identify components and mechanisms of nutrient-dependent mTORC1 signalling in regulatory T cells and reveal how mTORC1 integrates immunological cues and nutrient signals for adaptive immunity.

  • Lingyun Long
  • , Jun Wei
  •  & Hongbo Chi

• Article
  10 November 2021 | Open Access

  Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

  Seronegative healthcare workers with an innate signature of infection preferentially expand pre-existing T cells targeting the conserved replication transcription complex of SARS-CoV-2 in abortive infection.

  • Leo Swadling
  • , Mariana O. Diniz
  •  & Mala K. Maini

• Article | 27 October 2021

  Early-life inflammation primes a T helper 2 cell–fibroblast niche in skin

  Time-limited skin inflammation in neonatal mice promotes a reciprocal interaction between type 2 helper T cells and fascial fibroblasts that regulates wound repair in later life.

  • Ian C. Boothby
  • , Maxime J. Kinet
  •  & Michael D. Rosenblum

• Article | 01 September 2021

  Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer

  An analysis of human papillomavirus (HPV)-specific CD8 T cells in patients with head and neck cancer identifies functional PD-1⁺TCF-1⁺CD8 T cells in the tumour with implications for therapeutic vaccination and PD-1 directed immunotherapy.

  • Christiane S. Eberhardt
  • , Haydn T. Kissick
  •  & Rafi Ahmed

• Article | 21 July 2021

  Phenotype, specificity and avidity of antitumour CD8⁺ T cells in melanoma

  The authors use single-cell profiling and T cell receptor specificity screening to show how tumour antigen recognition shapes the phenotypes of CD8⁺ T cells and antitumour immune responses.

  • Giacomo Oliveira
  • , Kari Stromhaug
  •  & Catherine J. Wu

• Article
  21 July 2021 | Open Access

  Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

  Single-cell RNA sequencing and T cell receptor sequencing are combined to identify transcriptional programs specific to mutation-associated neoantigen-specific T cells in non-small cell lung cancers treated with anti-PD-1, providing insights into resistance to PD-1 blockade.

  • Justina X. Caushi
  • , Jiajia Zhang
  •  & Kellie N. Smith

• Review Article | 21 July 2021

  A multilayered immune system through the lens of unconventional T cells

  This Review provides an overview of our current understanding of the unconventional T cell compartment and discusses the development and function of unconventional T cells from an evolutionary perspective.

  • Toufic Mayassi
  • , Luis B. Barreiro
  •  & Bana Jabri

• Article | 07 July 2021

  Metabolic control of T_FH cells and humoral immunity by phosphatidylethanolamine

  Enzymes in the cytidine diphosphate–ethanolamine metabolic pathway, which promotes de novo synthesis of phosphatidylethanolamine, are shown to act as post-transcriptional mediators of the differentiation of T follicular helper (T_FH) cells, by regulating the chemokine receptor CXCR5.

  • Guotong Fu
  • , Clifford S. Guy
  •  & Hongbo Chi

• Article | 17 March 2021

  Expansible residence decentralizes immune homeostasis

  Investigations in mice using parabiosis and cohousing experiments reveal that nonlymphoid organs serve as reservoirs of tissue-autonomous cellular immunity, leading to the decentralization of organism-level immune homeostasis.

  • Sathi Wijeyesinghe
  • , Lalit K. Beura
  •  & David Masopust

• Article | 24 February 2021

  Lipid signalling enforces functional specialization of T_reg cells in tumours

  Identification of a metabolic checkpoint involving lipid signalling that is specific to regulatory T cells (T_reg cells) in the tumour microenvironment raises the possibility of targeting this checkpoint for treatment of cancer.

  • Seon Ah Lim
  • , Jun Wei
  •  & Hongbo Chi

• Article | 15 February 2021

  Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

  The tumour microenvironment is low in glucose and high in the alternative metabolite lactate, which regulatory T cells are shown here to use, maintaining their ability to suppress effector immune cells.

  • McLane J. Watson
  • , Paolo D. A. Vignali
  •  & Greg M. Delgoffe

• Article | 03 February 2021

  Dynamic regulation of T_FH selection during the germinal centre reaction

  T follicular helper cells undergo antigen-dependent selection in germinal centres, with higher-affinity T cell receptors supporting stronger proliferation leading to their clonal dominance.

  • Julia Merkenschlager
  • , Shlomo Finkin
  •  & Michel C. Nussenzweig

• Article | 19 February 2020

  γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

  Vγ6⁺ Vδ1⁺ γδ T cells control tolerance to cold by activating adipocyte IL-17RC and promoting sympathetic innervation of thermogenic adipose tissue in mice.

  • Bo Hu
  • , Chengcheng Jin
  •  & Bruce M. Spiegelman

• Article | 22 January 2020

  Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8⁺ cells

  The interleukin-15 superagonist N-803, combined with the depletion of CD8⁺ lymphocytes, induced a robust and persistent reactivation of the virus in vivo in both antiretroviral-therapy-treated SIV-infected macaques and HIV-infected humanized mice.

  • Julia Bergild McBrien
  • , Maud Mavigner
  •  & Guido Silvestri

• Article | 11 December 2019

  An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

  The authors examine the immune cell infiltrates of human tumours and provide evidence for a population of CD8 T cells with stem-cell characteristics and proliferative capacity that reside in an antigen-presenting niche within tumours.

  • Caroline S. Jansen
  • , Nataliya Prokhnevska
  •  & Haydn Kissick

• Article | 11 December 2019

  Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

  CRISPR–Cas9 mutagenesis screenings reveal that targeting REGNASE-1 leads to improved therapeutic efficacy of CD8⁺ T cells against mouse models of cancer, and identify BATF as a key target of REGNASE-1.

  • Jun Wei
  • , Lingyun Long
  •  & Hongbo Chi

• Article | 23 October 2019

  VISTA is an acidic pH-selective ligand for PSGL-1

  V-domain immunoglobulin suppressor of T cell activation (VISTA) selectively engages P-selectin glycoprotein ligand-1 (PSGL-1) and suppresses T cells at acidic pH similar to those in tumour microenvironments, thereby mediating resistance to anti-tumour immune responses.

  • Robert J. Johnston
  • , Linhui Julie Su
  •  & Alan J. Korman

• Article | 02 October 2019

  Dynamics and genomic landscape of CD8⁺ T cells undergoing hepatic priming

  CD8⁺ T cells that are primed by hepatocytes differentiate into dysfunctional T cells, which can be rescued by treatment with IL-2.

  • Alexandre P. Bénéchet
  • , Giorgia De Simone
  •  & Matteo Iannacone

• Letter | 19 June 2019

  Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

  Genetic, pharmacological and metabolomics experiments reveal that the malate–aspartate shuttle and mitochondrial citrate export support the differentiation of mouse T helper 1 cells, whereas succinate dehydrogenase enforces their terminal effector function.

  • Will Bailis
  • , Justin A. Shyer
  •  & Richard A. Flavell

• Letter | 17 June 2019

  TOX is a critical regulator of tumour-specific T cell differentiation

  The nuclear factor TOX is highly expressed in antigen-specific dysfunctional T cells in tumours and exhausted T cells during chronic viral infection and is a crucial regulator of the differentiation of tumour-specific T cells.

  • Andrew C. Scott
  • , Friederike Dündar
  •  & Andrea Schietinger

• Article | 17 June 2019

  TOX transcriptionally and epigenetically programs CD8⁺ T cell exhaustion

  The transcription factor TOX is a central regulator of the transcriptional and epigenetic development of exhausted T cells.

  • Omar Khan
  • , Josephine R. Giles
  •  & E. John Wherry

• Letter | 02 January 2019

  Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

  In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.

  • Minako Ito
  • , Kyoko Komai
  •  & Akihiko Yoshimura

• Letter | 19 December 2018

  Metabolic heterogeneity underlies reciprocal fates of T_H17 cell stemness and plasticity

  Phenotypically, transcriptionally and metabolically diverse subsets of T_H17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into T_H1 cells.

  • Peer W. F. Karmaus
  • , Xiang Chen
  •  & Hongbo Chi

• Letter | 07 November 2018

  The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

  Tetrahydrobiopterin (BH4) is an enzyme co-factor that is involved in the nervous system; it is shown here to also function in T cell activation and proliferation, with roles in autoimmunity, allergic inflammation and cancer.

  • Shane J. F. Cronin
  • , Corey Seehus
  •  & Josef M. Penninger

• Brief Communications Arising | 19 September 2018

  Evidence that CD32a does not mark the HIV-1 latent reservoir

  • Christa E. Osuna
  • , So-Yon Lim
  •  & James B. Whitney

• Letter | 18 July 2018

  Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

  A comprehensive analysis of the thymic medulla identifies a tuft-cell-like thymic epithelial cell population that is necessary for shaping thymic function.

  • Corey N. Miller
  • , Irina Proekt
  •  & Mark S. Anderson

• Letter | 25 October 2017

  Reversing SKI–SMAD4-mediated suppression is essential for T_H17 cell differentiation

  TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.

  • Song Zhang
  • , Motoki Takaku
  •  & Yisong Y. Wan

• Letter | 09 August 2017

  m⁶A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

  The authors assess the role of N⁶-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.

  • Hua-Bing Li
  • , Jiyu Tong
  •  & Richard A. Flavell

• Letter | 21 June 2017

  Identifying specificity groups in the T cell receptor repertoire

  The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.

  • Jacob Glanville
  • , Huang Huang
  •  & Mark M. Davis

• Letter | 24 May 2017

  Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

  The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.

  • Alejandra Mendoza
  • , Victoria Fang
  •  & Susan R. Schwab

• Letter | 02 February 2017

  Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

  The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.

  • Deepak A. Rao
  • , Michael F. Gurish
  •  & Michael B. Brenner

• Letter | 04 January 2017

  Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

  Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.

  • Louise van der Weyden
  • , Mark J. Arends
  •  & David J. Adams

• Article | 26 October 2016

  S-2-hydroxyglutarate regulates CD8⁺ T-lymphocyte fate

  S-2-hydroxyglutarate produced by CD8+ T cells under hypoxic conditions affects locus-specific histone and DNA methylation patterns, which enhances T-cell proliferation, survival and recall responses.

  • Petros A. Tyrakis
  • , Asis Palazon
  •  & Randall S. Johnson