CD8-positive T cells articles within Nature

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• Article
  15 November 2023 | Open Access

  Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer

  Analyses of causal gene regulatory networks have identified key checkpoints mediating the progressive differentiation of CD8⁺ cytotoxic T cells, findings that have implications for anticancer immunotherapies such as adoptive cell therapy and immune checkpoint blockade.

  • Peipei Zhou
  • , Hao Shi
  •  & Hongbo Chi

• Article | 20 September 2023

  The β₁-adrenergic receptor links sympathetic nerves to T cell exhaustion

  Stress-associated catecholamines promote CD8⁺ T cell exhaustion through the β₁-adrenergic receptor, and blocking β-adrenergic signalling may help restore anti-tumour functions.

  • Anna-Maria Globig
  • , Steven Zhao
  •  & Susan M. Kaech

• Article
  19 July 2023 | Open Access

  A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

  The human leukocyte antigen allele HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection due to pre-existing T cell immunity.

  • Danillo G. Augusto
  • , Lawton D. Murdolo
  •  & Jill A. Hollenbach

• Article | 28 September 2022

  PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program

  PD-1⁺TCF1⁺ stem-like CD8⁺ T cells—precursors of exhausted CD8⁺ T cells—are not fate-locked into the exhaustion program; their differentiation trajectory can be changed by IL-2 signals.

  • Masao Hashimoto
  • , Koichi Araki
  •  & Rafi Ahmed

• Article | 22 June 2022

  cBAF complex components and MYC cooperate early in CD8⁺ T cell fate

  cBAF is a negative determinant of memory T cell fate and the manipulation of cBAF early in T cell differentiation can improve cancer immunotherapy.

  • Ao Guo
  • , Hongling Huang
  •  & Douglas R. Green

• Article | 01 September 2021

  Functional HPV-specific PD-1⁺ stem-like CD8 T cells in head and neck cancer

  An analysis of human papillomavirus (HPV)-specific CD8 T cells in patients with head and neck cancer identifies functional PD-1⁺TCF-1⁺CD8 T cells in the tumour with implications for therapeutic vaccination and PD-1 directed immunotherapy.

  • Christiane S. Eberhardt
  • , Haydn T. Kissick
  •  & Rafi Ahmed

• Article | 21 July 2021

  Phenotype, specificity and avidity of antitumour CD8⁺ T cells in melanoma

  The authors use single-cell profiling and T cell receptor specificity screening to show how tumour antigen recognition shapes the phenotypes of CD8⁺ T cells and antitumour immune responses.

  • Giacomo Oliveira
  • , Kari Stromhaug
  •  & Catherine J. Wu

• Article
  21 July 2021 | Open Access

  Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

  Single-cell RNA sequencing and T cell receptor sequencing are combined to identify transcriptional programs specific to mutation-associated neoantigen-specific T cells in non-small cell lung cancers treated with anti-PD-1, providing insights into resistance to PD-1 blockade.

  • Justina X. Caushi
  • , Jiajia Zhang
  •  & Kellie N. Smith

• Article | 22 January 2020

  Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8⁺ cells

  The interleukin-15 superagonist N-803, combined with the depletion of CD8⁺ lymphocytes, induced a robust and persistent reactivation of the virus in vivo in both antiretroviral-therapy-treated SIV-infected macaques and HIV-infected humanized mice.

  • Julia Bergild McBrien
  • , Maud Mavigner
  •  & Guido Silvestri

• Article | 11 December 2019

  An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

  The authors examine the immune cell infiltrates of human tumours and provide evidence for a population of CD8 T cells with stem-cell characteristics and proliferative capacity that reside in an antigen-presenting niche within tumours.

  • Caroline S. Jansen
  • , Nataliya Prokhnevska
  •  & Haydn Kissick

• Article | 11 December 2019

  Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

  CRISPR–Cas9 mutagenesis screenings reveal that targeting REGNASE-1 leads to improved therapeutic efficacy of CD8⁺ T cells against mouse models of cancer, and identify BATF as a key target of REGNASE-1.

  • Jun Wei
  • , Lingyun Long
  •  & Hongbo Chi

• Article | 02 October 2019

  Dynamics and genomic landscape of CD8⁺ T cells undergoing hepatic priming

  CD8⁺ T cells that are primed by hepatocytes differentiate into dysfunctional T cells, which can be rescued by treatment with IL-2.

  • Alexandre P. Bénéchet
  • , Giorgia De Simone
  •  & Matteo Iannacone

• Article | 17 June 2019

  TOX transcriptionally and epigenetically programs CD8⁺ T cell exhaustion

  The transcription factor TOX is a central regulator of the transcriptional and epigenetic development of exhausted T cells.

  • Omar Khan
  • , Josephine R. Giles
  •  & E. John Wherry

• Article | 26 October 2016

  S-2-hydroxyglutarate regulates CD8⁺ T-lymphocyte fate

  S-2-hydroxyglutarate produced by CD8+ T cells under hypoxic conditions affects locus-specific histone and DNA methylation patterns, which enhances T-cell proliferation, survival and recall responses.

  • Petros A. Tyrakis
  • , Asis Palazon
  •  & Randall S. Johnson

• Letter | 11 April 2016

  Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

  The asymmetric distribution of mTORC1 and c-Myc in the first division of daughter cells of activated CD8 T cells affects the proliferation, metabolism and differentiation potential of their progeny.

  • Katherine C. Verbist
  • , Cliff S. Guy
  •  & Douglas R. Green

• Letter | 29 June 2015

  T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

  CD8 T-cell exhaustion, although a negative prognostic indicator during persistent infections, is shown to be associated with a good outcome in autoimmune and inflammatory diseases.

  • Eoin F. McKinney
  • , James C. Lee
  •  & Kenneth G. C. Smith

• Letter | 10 October 2012

  Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

  A genetically engineered mouse model is used to determine the mechanism of acquired resistance to adoptive therapy with cytotoxic T cells specific for a melanocytic differentiation antigen; tumour necrosis factor (TNF)-α is identified as a crucial factor that causes reversible dedifferentiation of mouse and human melanoma cells.

  • Jennifer Landsberg
  • , Judith Kohlmeyer
  •  & Thomas Tüting

• Letter | 20 November 2011

  Natural killer cells act as rheostats modulating antiviral T cells

  Natural killer cells can act as rheostats, or ‘master regulators’, controlling antiviral T-cell responses.

  • Stephen N. Waggoner
  • , Markus Cornberg
  •  & Raymond M. Welsh

• Letter | 30 March 2011

  Cross-dressed dendritic cells drive memory CD8⁺ T-cell activation after viral infection

  This study shows that memory T-cell activation in viral infection occurs, in part, by cross-dressing; that is, the transfer of loaded MHC-peptide molecules from an infected cell to dendritic cells.

  • Linda M. Wakim
  •  & Michael J. Bevan

• Letter | 16 September 2010

  Inhibition of follicular T-helper cells by CD8⁺ regulatory T cells is essential for self tolerance

  Immune cells that recognize 'self' tissues need to be eliminated or controlled in order to prevent autoimmune diseases. Here, a T-cell population is delineated that is necessary to maintain self tolerance in mice. Genetic disruption of the inhibitory interaction between these CD8⁺ T cells and their target Qa-1⁺ follicular T-helper cells results in a lethal systemic-lupus-erythematosus-like autoimmune disease.

  • Hye-Jung Kim
  • , Bert Verbinnen
  •  & Harvey Cantor