Cellular imaging articles within Nature

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  • Article
    | Open Access

    Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

    • Jonathan E. Tullis
    • , Matthew E. Larsen
    •  & K. Ulrich Bayer

  • Article
    | Open Access

    Micronuclei, which are common features of nuclei in cancer cells, can generate heritable sources of transcriptional suppression, a finding that establishes an inherent relationship between chromosomal instability and variation in chromatin state and gene expression.

    • Stamatis Papathanasiou
    • , Nikos A. Mynhier
    •  & David Pellman

  • Article |

    Functional mutations identified in patients with androgen insensitivity syndrome, in the formin and actin nucleator DAAM2, uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.

    • Julian Knerr
    • , Ralf Werner
    •  & Nadine C. Hornig

  • Article
    | Open Access

    Single-molecule calibrated live microscopy and computational modelling have revealed that human nuclear pore complex assembly takes different pathways during the exit from mitosis and during nuclear growth in interphase.

    • Shotaro Otsuka
    • , Jeremy O. B. Tempkin
    •  & Jan Ellenberg

  • Article |

    β2-adrenergic receptor(β2AR) signalling induces ERK activity at endosomes, but not at the plasma membrane, and this activity is dependent on active, endosome-localized Gαs and requires ligand-stimulated β2AR endocytosis.

    • Yonghoon Kwon
    • , Sohum Mehta
    •  & Jin Zhang

  • Article |

    High-dimensional datasets derived from time-resolved live imaging of leukocytes in mice were used to identify leukocyte identities and dynamic neutrophil states with high cellular resolution.

    • Georgiana Crainiciuc
    • , Miguel Palomino-Segura
    •  & Andrés Hidalgo

  • Article |

    Focused ion beam scanning electron microscopy (FIB-SEM) combined with deep-learning-based segmentation is used to produce three-dimensional reconstructions of complete cells and tissues, in which up to 35 different organelle classes are annotated.

    • Larissa Heinrich
    • , Davis Bennett
    •  & Destiny Nguyen

  • Article
    | Open Access

    Observations of rapid repair of double-stranded DNA breaks in sister choromosomes in Escherichia coli are consistent with a reduced-dimensionality-search model of RecA-mediated repair.

    • Jakub Wiktor
    • , Arvid H. Gynnå
    •  & Johan Elf

  • Article |

    Cyclopamine and its chemical analogue A3E inhibit replication of human respiratory syncytial virus (RSV) by hardening the liquid–liquid phase-separated inclusion bodies, resulting in the inhibition of virus replication in the lungs of RSV-infected mice.

    • Jennifer Risso-Ballester
    • , Marie Galloux
    •  & Ralf Altmeyer

  • Article
    | Open Access

    A genetically encoded sensor for the quantitative visualization of auxin distribution in plants enables real-time monitoring of its uptake and clearance by individual cells and within cellular compartments.

    • Ole Herud-Sikimić
    • , Andre C. Stiel
    •  & Gerd Jürgens

  • Article |

    Mechanical load-sharing enables the long-range cooperative uptake of apoptotic cells by multiple epithelial cells; and clearance of these apoptotic cells facilitates error correction, which is necessary for developmental robustness and survival of the embryo.

    • Esteban Hoijman
    • , Hanna-Maria Häkkinen
    •  & Verena Ruprecht

  • Article |

    Differences in the mechanical properties of individual cardiomyocytes drive their segregation into compact versus trabecular layer, thereby transforming the myocardium in a developing heart from a simple epithelium into an intricately patterned tissue with distinct cell fates.

    • Rashmi Priya
    • , Srinivas Allanki
    •  & Didier Y. R. Stainier

  • Article |

    An organoid-based screening platform maps the genetic interactions underlying intestinal development and regeneration, showing that retinoic acid metabolism maintains the balance between regeneration and homeostasis, and that an antagonist of the retinoid X receptor promotes regeneration in vivo.

    • Ilya Lukonin
    • , Denise Serra
    •  & Prisca Liberali

  • Letter |

    The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.

    • Ulrich Elling
    • , Reiner A. Wimmer
    •  & Josef M. Penninger

  • Letter |

    Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.

    • Hee Won Yang
    • , Mingyu Chung
    •  & Tobias Meyer

  • Letter |

    Rotary molecular machines, activated by ultraviolet light, are able to perturb and drill into cell membranes in a controllable manner, and more efficiently than those exhibiting flip-flopping or random motion.

    • Víctor García-López
    • , Fang Chen
    •  & James M. Tour

  • Article |

    A chromosome conformation capture method in which single cells are first imaged and then processed enables intact genome folding to be studied at a scale of 100 kb, validated, and analysed to generate hypotheses about 3D genomic interactions and organisation.

    • Tim J. Stevens
    • , David Lando
    •  & Ernest D. Laue

  • Letter |

    Cryo-electron tomography reveals a detailed view of the structural organization of the lamin meshwork within the lamina of the mammalian cell nucleus.

    • Yagmur Turgay
    • , Matthias Eibauer
    •  & Ohad Medalia

  • Letter |

    Synaptic vesicle fusion, as evoked by action potentials, is confined to presynaptic protein nanoclusters, which are closely aligned with concentrated postsynaptic receptors and their scaffolding proteins—an organization termed a ‘nanocolumn’.

    • Ai-Hui Tang
    • , Haiwen Chen
    •  & Thomas A. Blanpied

  • Letter |

    Super-resolution imaging provides direct evidence in live cells that membrane fusion and fission are mediated through an intermediate hemi-fused structure, where fusion and calcium/dynamin-dependent fission mechanisms compete to determine the transition of the intermediate to fusion or fission.

    • Wei-Dong Zhao
    • , Edaeni Hamid
    •  & Ling-Gang Wu

  • Letter |

    The interplay of histone acetylation and RNA polymerase II activity is investigated using fluorescence microscopy; acetylation of H3 at Lys 27 enhances the recruitment of a transcriptional activator and accelerates the transition of RNA polymerase II from initiation to elongation, thus indicating that histone acetylation has a causal effect on two distinct steps in transcription activation.

    • Timothy J. Stasevich
    • , Yoko Hayashi-Takanaka
    •  & Hiroshi Kimura

  • Letter |

    Although nectar is known to be important, for example in plant–insect interactions, little has been known about the mechanism of its secretion; sucrose phosphate synthases are now reported to be essential for the synthesis of the sucrose component of nectar and the transporter protein SWEET9 is shown to mediate sucrose export into the extracellular space of the nectary.

    • I Winnie Lin
    • , Davide Sosso
    •  & Wolf B. Frommer

  • Letter |

    A diamond chip with nitrogen–vacancy centres is used for magnetic imaging of living magnetotactic bacteria with sub-cellular spatial resolution.

    • D. Le Sage
    • , K. Arai
    •  & R. L. Walsworth

  • Letter |

    A non-invasive method is used to study and manipulate hair-follicle regeneration over time in live mice, and shows that hair growth involves spatially regulated cell divisions, cellular reorganization and migration of epithelial cells, and that the mesenchyme is required for hair growth.

    • Panteleimon Rompolas
    • , Elizabeth R. Deschene
    •  & Valentina Greco

  • Technology Feature |

    Long-term, live-cell imaging helps to settle long-running debates. Monya Baker investigates how the huge investment and time commitment is finally paying off.

    • Monya Baker

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