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Collective sensing in electric fish
Through modelling, neural recordings and behavioural experiments, a study shows that individual electric fish use electrical pulses of conspecifics to extend their electrolocation range, discriminate objects and increase information transmission.
- Federico Pedraja
- & Nathaniel B. Sawtell
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Article
| Open Access
Subicular neurons encode concave and convex geometries
Longitudinal calcium imaging reveals the ability of corner cells to synchronize their activity with the environment, with the results implying the potential of the subiculum to contain the information required to reconstruct spatial environments.
- Yanjun Sun
- , Douglas A. Nitz
- & Lisa M. Giocomo
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Article
| Open Access
A vagal reflex evoked by airway closure
A specific neural reflex of the vagus nerve is identified that induces gasping in response to airway closure.
- Michael S. Schappe
- , Philip A. Brinn
- & Stephen D. Liberles
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Cortical reactivations predict future sensory responses
Offline cortical reactivations predict the gradual drift and separation in sensory cortical response patterns and may enhance sensory discrimination.
- Nghia D. Nguyen
- , Andrew Lutas
- & Mark L. Andermann
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Article
| Open Access
A single photoreceptor splits perception and entrainment by cotransmission
The Drosophila R8 photoreceptor separates signals for image perception and circadian photoentrainment by co-releasing histamine and acetylcholine, and this segregation is further established in the postsynaptic circuitry in the medulla.
- Na Xiao
- , Shuang Xu
- & Dong-Gen Luo
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Article
| Open Access
Cortico-cortical feedback engages active dendrites in visual cortex
Feedback influence from a higher visual area to primary visual cortex in mice engages nonlinear dendritic integration.
- Mehmet Fişek
- , Dustin Herrmann
- & Michael Häusser
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Article
| Open Access
Multisensory learning binds neurons into a cross-modal memory engram
Multisensory learning improves subsequent memory performance, even for individual sensory cues, in Drosophila.
- Zeynep Okray
- , Pedro F. Jacob
- & Scott Waddell
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Article
| Open Access
Essential elements of radical pair magnetosensitivity in Drosophila
Non-CRYPTOCHROME-dependent radical pairs can elicit responses to magnetic fields in neurons in Drosophila melanogaster.
- Adam A. Bradlaugh
- , Giorgio Fedele
- & Richard A. Baines
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Article
| Open Access
The cellular coding of temperature in the mammalian cortex
A study using calcium imaging in the mouse forepaw system identifies neurons in the posterior insular cortex that respond to cooling and/or warming with distinct response dynamics.
- M. Vestergaard
- , M. Carta
- & J. F. A. Poulet
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Pathogenic bacteria modulate pheromone response to promote mating
Infection of Caenorhabditis elegans by Pseudomonas aeruginosa causes an increased pheromone response via the pheromone receptor STR-44 and increases mating with males, a potential mechanism for promoting adaptation in the host.
- Taihong Wu
- , Minghai Ge
- & Yun Zhang
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Article
| Open Access
The encoding of touch by somatotopically aligned dorsal column subdivisions
Distinct subdivisions of low-threshold mechanoreceptors and postsynaptic dorsal column neurons converge at the dorsal column nuclei to code precise tactile representations.
- Josef Turecek
- , Brendan P. Lehnert
- & David D. Ginty
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State-dependent pupil dilation rapidly shifts visual feature selectivity
Computational modelling and functional imaging of awake, active mice show that behaviour directly changes neuronal tuning in the visual cortex through pupil dilation.
- Katrin Franke
- , Konstantin F. Willeke
- & Andreas S. Tolias
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Article
| Open Access
A brainstem map for visceral sensations
In vivo two-photon calcium imaging analyses of sensory inputs from the gastrointestinal tract and upper airways in mice reveal spatial organization and coding principles of the interoceptive nervous system.
- Chen Ran
- , Jack C. Boettcher
- & Stephen D. Liberles
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Article
| Open Access
Visual recognition of social signals by a tectothalamic neural circuit
A tectothalamic pathway for social affiliation in developing zebrafish dissociates neuronal control of attraction from repulsion during affiliation, revealing a circuit underpinning of collective behaviour
- Johannes M. Kappel
- , Dominique Förster
- & Johannes Larsch
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The neuronal logic of how internal states control food choice
High-resolution volumetric calcium imaging was used to create a functional atlas of the Drosophila melanogaster ventral brain and identify how and where metabolic and reproductive states alter processing of food-related sensory stimuli.
- Daniel Münch
- , Dennis Goldschmidt
- & Carlos Ribeiro
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Revival of light signalling in the postmortem mouse and human retina
Experiments measuring light-evoked responses in postmortem mouse and human retinas are used to quantify decay of photoreceptors following death and optimise conditions for reviving trans-synaptic transmission.
- Fatima Abbas
- , Silke Becker
- & Frans Vinberg
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Mosquito brains encode unique features of human odour to drive host seeking
Select chemical compounds enriched in human odour activate an olfactory glomerulus in the brain of Aedes aegypti mosquitoes, which strengthens host-seeking behaviour and helps explain their strong preference for biting humans.
- Zhilei Zhao
- , Jessica L. Zung
- & Carolyn S. McBride
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Modulation of inhibitory communication coordinates looking and reaching
During combined looking and reaching movements, neurons in the reach region of the brain can inhibit those in the saccade region to improve coordination.
- Maureen A. Hagan
- & Bijan Pesaran
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Article
| Open Access
A multidimensional coding architecture of the vagal interoceptive system
Single-cell profiling of vagal sensory neurons from seven organs in mice and calcium-imaging-guided spatial transcriptomics reveal that interoceptive signals are coded through three distinct dimensions, allowing efficient processing of multiple signals in parallel using a combinatorial strategy.
- Qiancheng Zhao
- , Chuyue D. Yu
- & Rui B. Chang
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Cortical processing of flexible and context-dependent sensorimotor sequences
A sequence licking task reveals a set of key cortical regions for the coding of movement sequences in mice.
- Duo Xu
- , Mingyuan Dong
- & Daniel H. O’Connor
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A nutrient-specific gut hormone arbitrates between courtship and feeding
Diuretic hormone 31 secreted by the gut in response to feeding on protein-rich food excites brain neurons that promote switching from feeding to mating behaviour in Drosophila.
- Hui-Hao Lin
- , Meihua Christina Kuang
- & Jing W. Wang
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Spatial maps in piriform cortex during olfactory navigation
Studies using neural ensemble recordings in rats show that cells in the piriform cortex carry a spatial representation of the environment and link locations to olfactory sensory inputs.
- Cindy Poo
- , Gautam Agarwal
- & Zachary F. Mainen
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Cortical responses to touch reflect subcortical integration of LTMR signals
Genetic manipulation of skin peripheral sensory neurons in mice shows that cortical neuron responses to touch reflect subcortical mixing of signals from both rapidly adapting and slowly adapting low-threshold mechanoreceptors.
- Alan J. Emanuel
- , Brendan P. Lehnert
- & David D. Ginty
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Article
| Open Access
The structural basis of odorant recognition in insect olfactory receptors
Structural and functional analysis of an insect olfactory receptor shed light on how receptors can be activated by diverse odorants.
- Josefina del Mármol
- , Mackenzie A. Yedlin
- & Vanessa Ruta
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Sexual arousal gates visual processing during Drosophila courtship
Specific neurons in the fly brain that are activated when males are aroused modulate visual processing to underlie courtship.
- Tom Hindmarsh Sten
- , Rufei Li
- & Vanessa Ruta
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Representational drift in primary olfactory cortex
All odours elicit a unique pattern of neuronal activity in primary olfactory cortex but these patterns drift over time, posing a problem for the perceptual constancy of odours.
- Carl E. Schoonover
- , Sarah N. Ohashi
- & Andrew J. P. Fink
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Fast odour dynamics are encoded in the olfactory system and guide behaviour
Fast temporal dynamics of the olfactory environment can be perceived by mice and used to perform scene segmentation.
- Tobias Ackels
- , Andrew Erskine
- & Andreas T. Schaefer
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Inter-mosaic coordination of retinal receptive fields
Complementary types of retinal ganglion cell form mosaics with receptive fields that are farther apart than would be expected by chance, supporting the efficient coding of natural scenes.
- Suva Roy
- , Na Young Jun
- & Greg D. Field
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Hunger enhances food-odour attraction through a neuropeptide Y spotlight
Attraction to food odours is enhanced in mice that are experiencing hunger through a mechanism involving neuropeptide Y.
- Nao Horio
- & Stephen D. Liberles
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Survey of spiking in the mouse visual system reveals functional hierarchy
A large, open dataset containing parallel recordings from six visual cortical and two thalamic areas of the mouse brain is presented, from which the relative timing of activity in response to visual stimuli and behaviour is used to construct a hierarchy scheme that corresponds to anatomical connectivity data.
- Joshua H. Siegle
- , Xiaoxuan Jia
- & Christof Koch
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Structure and function of a neocortical synapse
Electrophysiology combined with correlated light and electron microscopy confirms the long-standing assumption that the size of a synapse is proportional to its strength, and reveals that neocortical synapses may have greater computational capacity than thought.
- Simone Holler
- , German Köstinger
- & Ken J. Stratford
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STING controls nociception via type I interferon signalling in sensory neurons
Studies using mouse and non-human primate models identify the innate immune regulator STING—acting via type I interferons—as a key regulator of nociception, suggesting new targets for the treatment of chronic pain.
- Christopher R. Donnelly
- , Changyu Jiang
- & Ru-Rong Ji
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Cortical response selectivity derives from strength in numbers of synapses
Live neuron imaging and electron microscopy reconstruction shows that the selectivity of cortical neuron responses to visual stimuli arises from the total number of synapses activated rather than being dominated by a small number of strong synaptic inputs.
- Benjamin Scholl
- , Connon I. Thomas
- & David Fitzpatrick
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Parallel ascending spinal pathways for affective touch and pain
Two populations of neurons with distinct anatomy and receptor expression that convey information from the spinal cord to the brain have different functional properties with respect to touch and pain.
- Seungwon Choi
- , Junichi Hachisuka
- & David D. Ginty
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Spontaneous travelling cortical waves gate perception in behaving primates
Timing and position of spontaneously arising waves of activity in the visual cortex predict the sensitivity of visual perception in awake, behaving marmosets (Callithrix jacchus).
- Zachary W. Davis
- , Lyle Muller
- & John H. Reynolds
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Value-guided remapping of sensory cortex by lateral orbitofrontal cortex
Dynamic interaction of neurons in lateral orbitofrontal cortex with the sensory cortex implements value-prediction computations that are history dependent and error based, providing plasticity essential for flexible decision-making.
- Abhishek Banerjee
- , Giuseppe Parente
- & Fritjof Helmchen
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Two dynamically distinct circuits drive inhibition in the sensory thalamus
In the thalamic reticular nucleus there are two neuron types that are segregated into central and edge zones and receive inputs from different thalamocortical nuclei, creating subcircuits with distinct dynamics.
- Rosa I. Martinez-Garcia
- , Bettina Voelcker
- & Scott J. Cruikshank
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Sodium regulates clock time and output via an excitatory GABAergic pathway
The authors demonstrate that clock time can be regulated by non-photic physiologically relevant cues and that such cues can drive unscheduled homeostatic responses via clock-output networks.
- Claire Gizowski
- & Charles W. Bourque
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Structure and flexibility in cortical representations of odour space
Both piriform cortex and its sensory inputs from the olfactory bulb represent chemical odour relationships, but cortex reshapes relational information inherited from the sensory periphery to enhance odour generalization and to reflect experience.
- Stan L. Pashkovski
- , Giuliano Iurilli
- & Sandeep Robert Datta
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Recurrent interactions in local cortical circuits
Computational modelling, imaging and single-cell ablation in layer 2/3 of the mouse vibrissal somatosensory cortex reveals that recurrent activity in cortical neurons can drive input-specific amplification during behaviour.
- Simon Peron
- , Ravi Pancholi
- & Karel Svoboda
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A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila
A pair of glucose-sensing neurons identified in the brain of Drosophila melanogaster regulates secretion of adipokinetic hormone and Drosophila insulin-like peptide 2, suggesting that these neurons have key roles in maintenance of glucose homeostasis.
- Yangkyun Oh
- , Jason Sih-Yu Lai
- & Greg S. B. Suh
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Letter |
Daytime colour preference in Drosophila depends on the circadian clock and TRP channels
Innate colour preference in adult fruit flies changes with the time of day, and depends on rhodopsins 1 and 7, TRP channels and the circadian clock.
- Stanislav Lazopulo
- , Andrey Lazopulo
- & Sheyum Syed
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Letter |
Feature-selective encoding of substrate vibrations in the forelimb somatosensory cortex
Responses to passive vibration of the forelimb in the mouse somatosensory cortex rely on a rate code that is selectively tuned to a combination of stimulus frequency and amplitude, and originate from deep mechanoreceptors close to the bones.
- Mario Prsa
- , Karin Morandell
- & Daniel Huber
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Single-neuron perturbations reveal feature-specific competition in V1
A combination of optogenetics and calcium imaging at the single-neuron level provides evidence for feature-specific competition among neurons in primary visual cortex.
- Selmaan N. Chettih
- & Christopher D. Harvey
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Letter |
Identifying the pathways required for coping behaviours associated with sustained pain
In mice, the ablation of spinal neurons that co-express TAC1 and LBX1 leads to the loss of coping responses to sustained pain without affecting reflexive defensive reactions to external threats.
- Tianwen Huang
- , Shing-Hong Lin
- & Qiufu Ma
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Letter |
A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour
A dopaminergic mesocortical circuit in juvenile zebra finches detects the presence of an adult zebra finch tutor and helps to encode the performance of the tutor, facilitating the cultural transmission of vocal behaviour.
- Masashi Tanaka
- , Fangmiao Sun
- & Richard Mooney
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Letter |
Sensation, movement and learning in the absence of barrel cortex
Mice can learn to detect objects with their whiskers and respond appropriately even in the absence of their primary somatosensory cortex.
- Y. Kate Hong
- , Clay O. Lacefield
- & Randy M. Bruno
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Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Somatosensory corticospinal neurons facilitate touch sensitivity and touch-evoked neuropathic pain in mice.
- Yuanyuan Liu
- , Alban Latremoliere
- & Zhigang He
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Letter |
Coherent encoding of subjective spatial position in visual cortex and hippocampus
When running through a virtual reality corridor, a mouse’s position is represented in both the hippocampus (as expected) and the primary visual cortex, for places that are visually identical.
- Aman B. Saleem
- , E. Mika Diamanti
- & Matteo Carandini
