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| Open AccessA new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out
- Jelmer Hoeksma
- , Tim Misset
- & Jeroen den Hertog
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| Open AccessPyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro
- Shunsuke Nomura
- , Hirotaka Takahashi
- & Tatsuya Sawasaki
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| Open AccessA suicide inhibitor of nematode trehalose-6-phosphate phosphatases
- Megan Cross
- , Mark York
- & Andreas Hofmann
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| Open AccessCaffeoyl-β-d-glucopyranoside and 1,3-dihydroxy-2-tetracosanoylamino-4-(E)-nonadecene isolated from Ranunculus muricatus exhibit antioxidant activity
- Farooq Azam
- , Bashir Ahmad Chaudhry
- & Muhammad Imran Qadir
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| Open AccessMultilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism
- Gabriel Fenteany
- , Paras Gaur
- & Lajos Haracska
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| Open AccessIdentification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen
- Eric A. Mosser
- , Cindy N. Chiu
- & David A. Prober
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| Open AccessExamination of molecular space and feasible structures of bioactive components of humic substances by FTICR MS data mining in ChEMBL database
- Alexey A. Orlov
- , Alexander Zherebker
- & Irina V. Perminova
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| Open AccessIdentifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA
- Andrés González
- , Sandra Salillas
- & Ángel Lanas
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| Open AccessDisruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ
- Cecilia Hurtado
- , Alena Safarova
- & Mark Mercola
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| Open AccessAn Unusually Broad Series of Seven Cyclombandakamines, Bridged Dimeric Naphthylisoquinoline Alkaloids from the Congolese Liana Ancistrocladus ealaensis
- Dieudonné Tshitenge Tshitenge
- , Torsten Bruhn
- & Gerhard Bringmann
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| Open AccessStructure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors
- Bernie Byunghoon Park
- , Jae Wan Choi
- & Young Ho Jeon
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| Open AccessDetermination and analysis of agonist and antagonist potential of naturally occurring flavonoids for estrogen receptor (ERα) by various parameters and molecular modelling approach
- Ninad V. Puranik
- , Pratibha Srivastava
- & Jayanthi Sivaraman
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| Open AccessCompetitive non-SELEX for the selective and rapid enrichment of DNA aptamers and its use in electrochemical aptasensor
- Ankita Kushwaha
- , Yuzuru Takamura
- & Manish Biyani
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| Open AccessNovel DNA Biosensor for Direct Determination of Carrageenan
- Riyadh Abdulmalek Hassan
- , Lee Yook Heng
- & Ling Ling Tan
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| Open Accessβ-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593
- Suresh Panthee
- , Shunji Takahashi
- & Hiroyuki Osada
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| Open AccessAnalysis of fluoroquinolones in dusts from intensive livestock farming and the co-occurrence of fluoroquinolone-resistant Escherichia coli
- Jochen Schulz
- , Nicole Kemper
- & Gerd Hamscher
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| Open AccessTracing recombinant bovine somatotropin ab(use) through transcriptomics: the potential of bovine somatic cells in a multi-dose longitudinal study
- Alexandre Lamas
- , Patricia Regal
- & Carlos Manuel Franco
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| Open AccessDistribution of organic and inorganic mercury across the pelts of Canadian river otter (Lontra canadensis)
- Kristin M. Eccles
- , Eric S. Littlewood
- & Hing Man Chan
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| Open AccessIsothermal Analysis of ThermoFluor Data can readily provide Quantitative Binding Affinities
- Nan Bai
- , Heinrich Roder
- & John Karanicolas
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| Open AccessAplysinopsin-type and Bromotyrosine-derived Alkaloids from the South China Sea Sponge Fascaplysinopsis reticulata
- Qi Wang
- , Xu-Li Tang
- & Guo-Qiang Li
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| Open AccessEffect of Chemical Permeation Enhancers on Skin Permeability: In silico screening using Molecular Dynamics simulations
- Rakesh Gupta
- , Dwadasi Balarama Sridhar
- & Samir Mitragotri
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| Open AccessHigh content screening identifies monensin as an EMT-selective cytotoxic compound
- Marion Vanneste
- , Qin Huang
- & Michael D. Henry
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| Open AccessIdentification of Thermus aquaticus DNA polymerase variants with increased mismatch discrimination and reverse transcriptase activity from a smart enzyme mutant library
- Govindan Raghunathan
- & Andreas Marx
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| Open AccessThe use of solid phase microextraction for metabolomic analysis of non-small cell lung carcinoma cell line (A549) after administration of combretastatin A4
- Karol Jaroch
- , Ezel Boyaci
- & Barbara Bojko
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| Open AccessA novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models
- Alisia M. Sim
- , Nabil A. Rashdan
- & Alison N. Hulme
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| Open AccessScaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation
- Francesca Grisoni
- , Daniel Merk
- & Gisbert Schneider
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| Open AccessIdentification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassay
- Cheongyun Jang
- , Dharmendra K. Yadav
- & Mi-hyun Kim
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| Open AccessExploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach
- Francesca Vasile
- , Serena Della Volpe
- & Simona Collina
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| Open AccessTissue degeneration in ALS affected spinal cord evaluated by Raman spectroscopy
- Gennaro Picardi
- , Alida Spalloni
- & Antonio Cricenti
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| Open AccessIsolation, Structure Elucidation, and Absolute Configuration of Germacrane Isomers from Carpesium divaricatum
- Tao Zhang
- , Jia-Huan Chen
- & Zhong-Mei Zou
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| Open AccessAbsorbance measurements of oxidation of homogentisic acid accelerated by the addition of alkaline solution with sodium hypochlorite pentahydrate
- Yasunori Tokuhara
- , Kenichi Shukuya
- & Tatsuo Shimosawa
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| Open AccessA powerful on line ABTS+–CE-DAD method to screen and quantify major antioxidants for quality control of Shuxuening Injection
- Huifen Ma
- , Jin Li
- & Yan-xu Chang
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| Open AccessThe Notch inhibitor cowanin accelerates nicastrin degradation
- Midori A. Arai
- , Ryuta Akamine
- & Masami Ishibashi
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| Open AccessMolecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study
- Dharmendra K. Yadav
- , Surendra Kumar
- & Mi-hyun Kim
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| Open AccessDetermining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay
- Joseph Shaw
- , Mathew Leveridge
- & Davide Gianni
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| Open AccessPotential Application of 1H NMR for Routine Serum Lipidome Analysis –Evaluation of Effects of Bariatric Surgery
- Adriana Mika
- , Zbigniew Kaczynski
- & Tomasz Sledzinski
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| Open AccessMilling overrides cultivar, leavening agent and baking mode on chemical and rheological traits and sensory perception of durum wheat breads
- Donatella Bianca Maria Ficco
- , Sergio Saia
- & Pasquale De Vita
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| Open AccessPharmacological use of a novel scaffold, anomeric N,N-diarylamino tetrahydropyran: molecular similarity search, chemocentric target profiling, and experimental evidence
- Arramshetti Venkanna
- , Oh Wook Kwon
- & Mi-hyun Kim
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| Open AccessIdentification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt
- Bill X. Huang
- , Kenny Newcomer
- & Hee-Yong Kim
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| Open AccessNovel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach
- Andrea R. Beccari
- , Marica Gemei
- & Giulio Vistoli
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| Open AccessPurple spot damage dynamics investigated by an integrated approach on a 1244 A.D. parchment roll from the Secret Vatican Archive
- Luciana Migliore
- , Maria Cristina Thaller
- & Alessandro Rubechini
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| Open AccessAn enhanced C. elegans based platform for toxicity assessment
- Huajiang Xiong
- , Catherine Pears
- & Alison Woollard
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| Open AccessRapid and accurate in silico solubility screening of a monoclonal antibody library
- Pietro Sormanni
- , Leanne Amery
- & Bojana Popovic
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| Open AccessRhodoterpenoids A‒C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
- Fei Liu
- , Ya-Nan Wang
- & Shi-Shan Yu
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| Open AccessThe Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket
- Anu Thomas
- , Chidananda Sulli
- & Joseph B. Rucker
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| Open AccessAn in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system
- Marion Kirchner
- , Kenji Schorpp
- & Sabine Schneider
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| Open AccessChemical characterization of the adhesive secretions of the salamander Plethodon shermani (Caudata, Plethodontidae)
- Janek von Byern
- , Ingo Grunwald
- & Martina Marchetti-Deschmann
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| Open AccessDesign and application of a lactulose biosensor
- Jieyuan Wu
- , Peixia Jiang
- & Shuang-Yan Tang
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| Open AccessAlizarin Red S for Online Pyrophosphate Detection Identified by a Rapid Screening Method
- Jens Fischbach
- , Qiuting Loh
- & Jörn Glökler