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| Open AccessTRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3
- Qi Zhang
- , Yong Li
- & Xuan Huang
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Article
| Open AccessReg4 deficiency aggravates pancreatitis by increasing mitochondrial cell death and fibrosis
- Weihui Yan
- , Ying Wang
- & Yongtao Xiao
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Article
| Open AccessTrauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes
- Julian Roos
- , Julia Zinngrebe
- & Pamela Fischer-Posovszky
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Article
| Open AccessFatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
- Hao Peng
- , Shan Xin
- & Joel A. Schick
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Article
| Open AccessELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance
- Cheol-Jung Lee
- , Heejung Lee
- & Yong-Yeon Cho
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Article
| Open AccessPDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway
- Yuanzhen Ma
- , Zhiyu Fang
- & Junfang Zheng
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Article
| Open AccessTransglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation
- Kaili Zhou
- , Chenglong Wu
- & Xue Zhang
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Article
| Open AccessThe broad impact of cell death genes on the human disease phenome
- Abigail L. Rich
- , Phillip Lin
- & Sandra S. Zinkel
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Review Article
| Open AccessThe role of RNA-modifying proteins in renal cell carcinoma
- Muna A. Alhammadi
- , Khuloud Bajbouj
- & Rifat Hamoudi
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Article
| Open AccessThe RNA m6A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer
- Lichen Ge
- , Yalan Rui
- & Junjun Wang
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Article
| Open AccessInnate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors
- Layla Shojaie
- , Jacob M. Bogdanov
- & Lily Dara
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Article
| Open AccessPRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling
- Tao Yang
- , Yongnan Chi
- & Denglong Wu
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Article
| Open AccessGITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice
- Li Li
- , Yu He
- & Ping Wang
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Article
| Open AccessIFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway
- Zhangsheng Xiong
- , Xiangdong Xu
- & Yang Liu
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Article
| Open AccessEpigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
- Shuang Ding
- , Haibin Liu
- & Wuxiang Guan
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Article
| Open AccessE3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis
- Yingjie Huang
- , Tao Chen
- & Yong Li
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Article
| Open AccessGp78 deficiency in hepatocytes alleviates hepatic ischemia-reperfusion injury via suppressing ACSL4-mediated ferroptosis
- Changbiao Li
- , Yichao Wu
- & Xiao Xu
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Article
| Open AccessThe C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis
- Mengfan Zhang
- , Yang Jing
- & Jianzhuang Ren
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Article
| Open AccessSulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling
- Chujun Ma
- , Chaode Gu
- & Zhonglan Su
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Article
| Open AccessAggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization
- Olivier Lurette
- , Rebeca Martín-Jiménez
- & Etienne Hebert-Chatelain
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Article
| Open AccessUSP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1
- Hongdian Zhang
- , Youming Han
- & Zhentao Yu
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Article
| Open AccessFallopian tube lesions as potential precursors of early ovarian cancer: a comprehensive proteomic analysis
- Maxence Wisztorski
- , Soulaimane Aboulouard
- & Michel Salzet
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Review Article
| Open AccessHearing loss and vestibular schwannoma: new insights into Schwann cells implication
- Tasnim Mohamed
- , Valentina Melfi
- & Valerio Magnaghi
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Article
| Open AccessInhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
- Xingdi Wu
- , Naiji Yu
- & Kaijun Wang
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Article
| Open AccessCXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation
- Wei Zhuang
- , Jinfeng Zhou
- & Changsheng Du
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Review Article
| Open AccessImmune landscape and redox imbalance during neurological disorders in COVID-19
- Abhimanyu Thakur
- , Vartika Sharma
- & Kui Zhang
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Article
| Open AccessMETTL16 controls Kaposi’s sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle
- Xinquan Zhang
- , Wen Meng
- & Shou-Jiang Gao
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Article
| Open AccessPancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
- Zhaolong Pan
- , Jan-Lars Van den Bossche
- & Ilse Rooman
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Review Article
| Open AccessSenescence program and its reprogramming in pancreatic premalignancy
- Kailing Yang
- , Xiaojia Li
- & Keping Xie
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Article
| Open AccessZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC
- Tongjia Zhang
- , Lizhen Qiu
- & Kailong Li
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Review Article
| Open AccessThe diversified role of mitochondria in ferroptosis in cancer
- Yu’e Liu
- , Shiping Lu
- & Jinghan Wang
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Article
| Open AccessNeuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
- Kang Zheng
- , Fengjie Hao
- & Francisco Javier Cubero
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Article
| Open AccessSRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1
- Xiao-Chen Xu
- , Jia-Xin Jiang
- & Chun-Ling Luo
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Article
| Open AccessInhibition of autotaxin alleviates pathological features of hepatic encephalopathy at the level of gut–liver–brain axis: an experimental and bioinformatic study
- Ali Sepehrinezhad
- , Ali Shahbazi
- & Sajad Sahab Negah
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Article
| Open AccessGOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response
- Theodomir Dusabimana
- , Jihyun Je
- & Sang Won Park
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Perspective
| Open AccessBalancing the functions of DNA extracellular traps in intracellular parasite infections: implications for host defense, disease pathology and therapy
- Carolina Cattoni Koh
- , Kenneth J. Gollob
- & Walderez O. Dutra
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Article
| Open AccessLoss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc
- Takashi Ohnishi
- , Victoria Tran
- & Makarand V. Risbud
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Article
| Open AccessIF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype
- Sonia Domínguez-Zorita
- , Inés Romero-Carramiñana
- & José M. Cuezva
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Article
| Open AccessATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury
- Ranran Li
- , Mei Meng
- & Lei Li
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Article
| Open AccessE3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR
- Jiaying Huang
- , Zhou Yu
- & Xuetao Cao
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Article
| Open AccessAAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice
- Shijie Zhang
- , Xiang Tong
- & Hong Fan
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Article
| Open AccessLoss of function of GATA3 regulates FRA1 and c-FOS to activate EMT and promote mammary tumorigenesis and metastasis
- Xiong Liu
- , Feng Bai
- & Xin-Hai Pei
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Article
| Open AccessButyrate limits inflammatory macrophage niche in NASH
- Ankita Sarkar
- , Priya Mitra
- & Partha Chakrabarti
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Article
| Open AccessNovel insight into the underlying dysregulation mechanisms of immune cell-to-cell communication by analyzing multitissue single-cell atlas of two COVID-19 patients
- Shijie Qin
- , Xiaohong Yao
- & Xiuwu Bian
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Article
| Open AccessEnhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization
- Xun Zhou
- , Hui Chen
- & Na Liu
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Article
| Open AccessRIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy
- Zijing Huang
- , Jiajian Liang
- & Dingguo Huang
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Article
| Open AccessPTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway
- Hui Li
- , Bingxin Guan
- & Peng Gao
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Article
| Open AccessNecroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis
- Shen Yang
- , Na Chang
- & Liying Li