Pancreatitis articles within Nature Communications

Featured

• Article
  04 October 2023 | Open Access

  Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

  Given the association of gut microbiota dysbiosis with hypertriglyceridemic pancreatitis (HTGP), authors assess the gut microbial diversity of patients with HTGP, and provide immunological insight utilising a murine model.

  • Guanqun Li
  • , Liwei Liu
  •  & Bei Sun

• Article
  03 August 2022 | Open Access

  In mouse chronic pancreatitis CD25⁺FOXP3⁺ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

  The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas associated with M2-like macrophages in vivo.

  • Juliane Glaubitz
  • , Anika Wilden
  •  & Matthias Sendler

• Article
  28 November 2018 | Open Access

  A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

  Inflammatory diseases of the pancreas are currently untreatable and lack a pre-clinical model that recapitulates the hallmarks of the human pathology. Here, the authors generate a knock-in mouse strain with increased tripsinogen autoactivation and show that it develops spontaneous pancreatic pathology with some key features of human pancreatitis.

  • Andrea Geisz
  •  & Miklós Sahin-Tóth

• Article
  11 March 2016 | Open Access

  Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

  Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.

  • Moritz Leppkes
  • , Christian Maueröder
  •  & Christoph Becker

• Article | 20 May 2015

  The oncogenic microRNA miR-21 promotes regulated necrosis in mice

  The microRNA miR-21 is overexpressed in cancer and is thought to function through anti-apoptotic activity. Here, Ma et al. show that deleting or blocking miR-21 in mice protects against acute pancreatitis and TNF-α-induced tissue damage by inhibiting RIP3-dependent regulated necrosis (necroptosis).

  • Xiaodong Ma
  • , Daniel J. Conklin
  •  & Yong Li

• Article | 18 May 2015

  Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

  Chronic pancreatitis is an inflammatory disease accompanied by fibrosis. Here the authors show that pancreatic stellate cells produce IL-4 and IL-13 that trigger alternative activation of macrophages, and that genetic or pharmacological inhibition of IL-4/IL-13 signaling ameliorates the disease.

  • Jing Xue
  • , Vishal Sharma
  •  & Aida Habtezion