Chronic pancreatitis articles within Nature Communications

Featured

• Article
  03 August 2022 | Open Access

  In mouse chronic pancreatitis CD25⁺FOXP3⁺ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

  The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas associated with M2-like macrophages in vivo.

  • Juliane Glaubitz
  • , Anika Wilden
  •  & Matthias Sendler

• Article
  28 November 2018 | Open Access

  A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

  Inflammatory diseases of the pancreas are currently untreatable and lack a pre-clinical model that recapitulates the hallmarks of the human pathology. Here, the authors generate a knock-in mouse strain with increased tripsinogen autoactivation and show that it develops spontaneous pancreatic pathology with some key features of human pancreatitis.

  • Andrea Geisz
  •  & Miklós Sahin-Tóth

• Article | 18 May 2015

  Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

  Chronic pancreatitis is an inflammatory disease accompanied by fibrosis. Here the authors show that pancreatic stellate cells produce IL-4 and IL-13 that trigger alternative activation of macrophages, and that genetic or pharmacological inhibition of IL-4/IL-13 signaling ameliorates the disease.

  • Jing Xue
  • , Vishal Sharma
  •  & Aida Habtezion