Featured
-
-
Article
| Open AccessChirality detection of enantiomers using twisted optical metamaterials
Here Zhaoet al. use twisted metamaterials to drastically enhance chiral responses through strong near-field interactions, and sense the chirality down to zeptomoles of molecules, orders of magnitude smaller than what is detectable with conventional circular dichroism spectroscopy.
- Yang Zhao
- , Amir N. Askarpour
- & Andrea Alù
-
Article
| Open AccessMultiplexed single-mode wavelength-to-time mapping of multimode light
Photonic lanterns are made by merging several single-mode cores into one multimode core. Here, the authors show this type of structure can both perform wavelength-to-time mapping of multimode states of light and couple such light to an array of single-photon avalanche detectors.
- Harikumar K Chandrasekharan
- , Frauke Izdebski
- & Robert R. Thomson
-
Article
| Open AccessScalable high-precision tuning of photonic resonators by resonant cavity-enhanced photoelectrochemical etching
Aligning the resonances of sets of optical cavities is necessary for advanced photonics and sensing applications. Here, the authors introduce resonant photoelectrochemical etching as a method to collectively and permanently tune the resonant wavelengths of ensembles of resonators on a photonic chip.
- Eduardo Gil-Santos
- , Christopher Baker
- & Ivan Favero
-
Article
| Open AccessTargeted DNA sequencing and in situ mutation analysis using mobile phone microscopy
On-site diagnostics technologies allow for rapid, cost-effective diagnosis with a particular importance for remote communities. Here the authors demonstrate the use of mobile phone based microscopy for targeted DNA sequencing andin situpoint mutation detection in tumours.
- Malte Kühnemund
- , Qingshan Wei
- & Mats Nilsson
-
Article
| Open AccessShifting molecular localization by plasmonic coupling in a single-molecule mirage
The near-field interaction of single emitters and plasmonic structures can alter the perceived physical location of the emitter. Here, Raabet al. use DNA origami and far-field super-resolution microscopy to quantitatively evaluate this localization offset for gold nanoparticles.
- Mario Raab
- , Carolin Vietz
- & Philip Tinnefeld
-
Article
| Open AccessSuper-resolution imaging of light–matter interactions near single semiconductor nanowires
Light-matter interactions with single quantum emitters are generally difficult to measure with both high-resolution and a large field of view. Here, Johlin et al. develop far-field super-resolution fluorescence methods to map near-field emitter-nanostructure interactions over several microns.
- Eric Johlin
- , Jacopo Solari
- & Erik C. Garnett
-
Article
| Open AccessScanning superlens microscopy for non-invasive large field-of-view visible light nanoscale imaging
Rare subcellular events can be tracked by correlating structural-information gathered by imaging with specific-molecule fluorescent identification. Here, the authors achieve this correlation in a quick and non-invasive way using microsphere-based scanning superlens microscopy.
- Feifei Wang
- , Lianqing Liu
- & Wen Jung Li
-
Article
| Open AccessMultiple signal classification algorithm for super-resolution fluorescence microscopy
Single-molecule localization microscopy offers super-resolution imaging, but needs a long acquisition time and a toxic photochemical environment. Here, the authors demonstrate a multiple signal classification algorithm that achieves a resolution of 50 nm with as few as 50 frames in a biologically conducive environment.
- Krishna Agarwal
- & Radek Macháň
-
Article
| Open AccessMulti-dimensional super-resolution imaging enables surface hydrophobicity mapping
Many super-resolution imaging techniques use fluorescence emission intensity to obtain precise positional information, but other spectral information is ignored. Here, the authors develop a method that records the spectrum and position of single dye molecules to map the hydrophobicity of a surface.
- Marie N. Bongiovanni
- , Julien Godet
- & Steven F. Lee
-
Article
| Open AccessPhase retrieval by coherent modulation imaging
Robust coherent diffractive imaging generally requires many exposures that may damage samples. Here, the authors develop a single-shot X-ray imaging method applicable to general samples for materials and biological sciences, also enabling imaging of dynamic processes, using a pulsed X-ray laser.
- Fucai Zhang
- , Bo Chen
- & Ian K. Robinson
-
Article
| Open AccessUltrasensitive plasmonic sensing in air using optical fibre spectral combs
Fibre sensors are key to many minimally-invasive detection techniques but, owing to an index mismatch, they are often limited to aqueous environments. Here, Caucheteur et al. develop a high-resolution fibre gas sensor with a tilted in-fibre grating that allows coupling to higher-order plasmon modes.
- Christophe Caucheteur
- , Tuan Guo
- & Jacques Albert
-
Article
| Open AccessContinuous injection synthesis of indium arsenide quantum dots emissive in the short-wavelength infrared
Indium arsenide quantum dots are promising materials for short-wavelength infrared emissive applications. Here, the authors investigate the kinetics of indium arsenide nanocrystal growth and design large quantum dots with narrow emission wavelengths which can be used for through-skull fluorescence imaging.
- Daniel Franke
- , Daniel K. Harris
- & Moungi G. Bawendi
-
Article
| Open AccessExploiting the speckle-correlation scattering matrix for a compact reference-free holographic image sensor
Holographic techniques store and retrieve complete optical information, but the requirement of a reference beam can make the process complicated and sensitive to noise. Here, the authors develop a reference-free method that harnesses self-interference in a diffusive scattering medium.
- KyeoReh Lee
- & YongKeun Park
-
Article
| Open AccessScattering-type scanning near-field optical microscopy with low-repetition-rate pulsed light source through phase-domain sampling
Low repetition rate lasers are suitable for studying nonlinear optical phenomena, while near-field microscopy allows high spatial resolution for nanomaterial characterisation. Here, Wang et al. enable scattering-type near-field microscopy with low repetition rate lasers through phase-domain sampling.
- Haomin Wang
- , Le Wang
- & Xiaoji G. Xu
-
Article
| Open AccessImaging and controlling plasmonic interference fields at buried interfaces
Visualizing surface plasmon polaritons at buried interfaces has remained elusive. Here, the authors develop a methodology to study the spatiotemporal evolution of buried near-fields within complex heterostructures, enabling the characterization of the next generation of plasmonic devices.
- Tom T. A. Lummen
- , Raymond J. Lamb
- & F. Carbone
-
Article
| Open AccessThermopile detector of light ellipticity
Differences in the intensity of the left- and right-circularly polarized components of light can provide useful information about the chirality of electromagnetic radiation. Here, the authors demonstrate a monolithic photodetector that translates this difference in incident radiation directly into a voltage
- Feng Lu
- , Jongwon Lee
- & Mikhail A. Belkin
-
Article
| Open AccessExperimental determination of excitonic band structures of single-walled carbon nanotubes using circular dichroism spectra
The experimental determination of band structure of single wall carbon nanotubes (SWCNTs) is a challenging task, and often must be theoretically predicted. Here, the authors separate SWCNTs in high purity and experimentally determine their excitonic band structures using circular dichroism spectra.
- Xiaojun Wei
- , Takeshi Tanaka
- & Hiromichi Kataura
-
Article
| Open AccessProjection-type see-through holographic three-dimensional display
The design of holographic displays usually involves a trade-off between size and viewing angle. Here, the authors combine holographic projection with a digitally designed holographic optical element so that display size and the visual angle can be designed independently.
- Koki Wakunami
- , Po-Yuan Hsieh
- & Kenji Yamamoto
-
Article
| Open AccessTransfer of optical orbital angular momentum to a bound electron
The spatial structure of vortex laser beams associates angular momentum to photons, which, in addition to their spin, can be used to tailor light-matter interactions. Here, the authors excite an atomic transition with a vortex laser beam, showing that the transfer of angular momentum modifies selection rules.
- Christian T. Schmiegelow
- , Jonas Schulz
- & Ferdinand Schmidt-Kaler
-
Article
| Open AccessThe optical frequency comb fibre spectrometer
An ideal optical frequency-comb system should combine both single-line spectral resolution and a bandwidth broad enough to cover as many lines as possible. Here, the authors incorporate a fibre spectrometer to detect approximately 500 comb-lines with an instrument resolution of 120 megahertz.
- Nicola Coluccelli
- , Marco Cassinerio
- & Gianluca Galzerano
-
Article
| Open AccessOptical manipulation of single flux quanta
Manipulation of individual superconducting vortices remains challenging and has been demonstrated only in a sophisticated way. Here, Veshchunov et al.realize a fast and precise manipulation of individual vortices using a far-field optical method, providing a simple way towards optical control of Josephson transport.
- I. S. Veshchunov
- , W. Magrini
- & B. Lounis
-
Article
| Open AccessMulti-pass microscopy
Low-damage and high-precision imaging can be achieved by passing the same probe photons through the specimen more than once, and this has been previously achieved in double-pass transmission microscopy. Here, the authors generalize this idea to full-field multi-pass microscopy using a self-imaging cavity.
- Thomas Juffmann
- , Brannon B. Klopfer
- & Mark A. Kasevich
-
Article
| Open AccessTerahertz time-gated spectral imaging for content extraction through layered structures
Terahertz radiation may be used to nondestructively detect and study defects and structures within materials. Here the authors use terahertz time-gated spectral imaging to extract occluded text from paper pages with subwavelength spacing.
- Albert Redo-Sanchez
- , Barmak Heshmat
- & Ramesh Raskar
-
Article
| Open AccessNanoscopic imaging of thick heterogeneous soft-matter structures in aqueous solution
Integration time limits the capacity of super-resolution microscopy to study dynamics. Here, Bartsch et al. use the 3D scanning of a nanoparticle held in an optical trap, and its thermal noise motion within the trap, to image the local dynamics of soft-matter structures with a 50 kHz bandwidth.
- Tobias F. Bartsch
- , Martin D. Kochanczyk
- & Ernst-Ludwig Florin
-
Article
| Open AccessNon-destructive imaging of buried electronic interfaces using a decelerated scanning electron beam
Imaging buried interfaces is necessary to assess the quality of electronic devices and their degradation mechanisms. Here, Hirohata et al. use energy-filtered scanning electron microscopy to image buried defects in an inorganic lateral spin-valve device, at the nanometre scale and non-destructively.
- Atsufumi Hirohata
- , Yasuaki Yamamoto
- & Andrew J. Vick
-
Article
| Open AccessDrosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves
It is unclear what role calcium signalling plays in the Drosophila wing disc. Here, the authors show that on mechanical stress, slow, long-range intercellular calcium waves are initiated in vivo and ex vivo, mediated by the inositol-3-phosphate receptor, the calcium pump SERCA and gap junction component Inx2.
- Simon Restrepo
- & Konrad Basler
-
Article
| Open AccessFar-field nanoscale infrared spectroscopy of vibrational fingerprints of molecules with graphene plasmons
Despite being a powerful tool for molecular vibrational mode detection, infrared spectrosocpy is limited by weak sensitivity. Here, the authors demonstrate a platform for enhanced molecular fingerprint sensing based on a graphene/CaF2nanofilm plasmonic structure.
- Hai Hu
- , Xiaoxia Yang
- & Qing Dai
-
Article
| Open AccessCavity optomechanical spring sensing of single molecules
Detection of a single nanoparticle or molecule is essential for many applications. Here, Yu et al.demonstrate the use of an optical cavity with optomechanical oscillation to detect single bovine serum albumin proteins, with potential for studying mechanical properties and interactions of individual molecules.
- Wenyan Yu
- , Wei C Jiang
- & Tao Lu
-
Article
| Open AccessANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation.
- Binod Aryal
- , Noemi Rotllan
- & Carlos Fernández-Hernando
-
Article
| Open AccessSuper-resolution spectroscopic microscopy via photon localization
Photon localization microscopy uses stochastic emission events from fluorescent molecules to enable super-resolution imaging, but spectroscopic information is lost. Here, the authors improve the spatial resolution of this technique with a method that also detects each blink’s fluorescence spectrum.
- Biqin Dong
- , Luay Almassalha
- & Hao F. Zhang
-
Article
| Open AccessUnderwater microscopy for in situ studies of benthic ecosystems
Underwater microscopes have limited spatial and temporal resolutions. Here, Mullen et al. present a small non-invasive underwater microscope for both direct and fluorescence microscopy. They image coral bleaching and interspecific competition with resolutions approaching a micron and hundreds of milliseconds.
- Andrew D. Mullen
- , Tali Treibitz
- & Jules S. Jaffe
-
Article
| Open AccessSingle-pixel three-dimensional imaging with time-based depth resolution
A three-dimensional imaging system which distributes the optical illumination over the full field-of-view is sought after. Here, the authors demonstrate the capability of reconstructing 128 × 128 pixel resolution three-dimensional scenes to an accuracy of 3 mm as well as real-time video with a frame-rate up to 12 Hz.
- Ming-Jie Sun
- , Matthew P. Edgar
- & Miles J. Padgett
-
Article
| Open AccessEigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues
Spectral corruption impedes imaging of blood oxygen saturation. Here Tzoumas et al.describe light fluence in the spectral domain and introduce eigenspectra Multispectral Optoacoustic Tomography to account for wavelength-dependent light attenuation and estimate blood oxygen saturation within deep tissue.
- Stratis Tzoumas
- , Antonio Nunes
- & Vasilis Ntziachristos
-
Article
| Open AccessPhoton-efficient imaging with a single-photon camera
Active optical imaging systems use their own light sources to recover scene information but typically operate with large number of photon detections. Here, the authors present a 3D imaging system that acquires depth and reflectivity information with a single photon camera operating in low-light conditions.
- Dongeek Shin
- , Feihu Xu
- & Jeffrey H. Shapiro
-
Article
| Open AccessOperating organic light-emitting diodes imaged by super-resolution spectroscopy
There is a need to characterize devices during operation in real-time and at nanoscopic length scales. Here, King et al. perform electroluminescence-STED imaging with a polymer based light-emitting diode, revealing nanoscopic defects that would be unresolvable with traditional optical microscopy.
- John T. King
- & Steve Granick
-
Article
| Open AccessThree-dimensional spatiotemporal focusing of holographic patterns
Three-dimensional computer-generated holography cannot be implemented with temporal focusing. Here, Hernandez et al. use two spatial light modulators to control transverse- and axial-target light distribution, generating spatiotemporally focused patterns with uniform light distribution throughout the entire volume.
- Oscar Hernandez
- , Eirini Papagiakoumou
- & Valentina Emiliani
-
Article
| Open AccessPlasmonic piezoelectric nanomechanical resonator for spectrally selective infrared sensing
Plasmonic metasurfaces can provide exciting optical functionalities. Here, Hui et al. demonstrate an infrared sensor by combining plasmonic and piezoelectric electromechanical resonances, demonstrating efficient transduction of vibration with a strong and polarization-independent absorption over an ultrathin thickness.
- Yu Hui
- , Juan Sebastian Gomez-Diaz
- & Matteo Rinaldi
-
Article
| Open AccessDiffractive imaging of a rotational wavepacket in nitrogen molecules with femtosecond megaelectronvolt electron pulses
Imaging changes in molecular geometries with sufficient temporal and spatial resolution to image nuclei is a critical challenge in the chemical sciences. Here the authors report gasphase Megaelectronvolt electron diffraction with 100 fs temporal resolution and subAngstrom spatial resolution.
- Jie Yang
- , Markus Guehr
- & Xijie Wang
-
Article
| Open AccessReal-time high dynamic range laser scanning microscopy
Confocal and multiphoton fluorescence microscopy often suffers from low dynamic range. Here the authors develop a high dynamic range, laser scanning fluorescence technique by simultaneously recording different light intensity ranges. The method can be adapted to commercial systems.
- C. Vinegoni
- , C. Leon Swisher
- & R. Weissleder
-
Article
| Open AccessDamage-free vibrational spectroscopy of biological materials in the electron microscope
Use of electron microscopy to determine morphology, or find where functionally significant biomolecules are located with high spatial resolution is of great interest. Here, Rez, Cohen et al. use aloof electron beam vibrational spectroscopy to probe different bonds in biological samples with no significant radiation damage.
- Peter Rez
- , Toshihiro Aoki
- & Hagai Cohen
-
Article
| Open AccessDirect single-shot phase retrieval from the diffraction pattern of separated objects
Short X-ray pulses from free-electron lasers enable coherent diffractive imaging of noncrystalline objects such as single molecules. Here, the authors reconstructing full image information from a single-shot diffraction pattern by using two sufficiently separated objects to act as references for each other.
- Ben Leshem
- , Rui Xu
- & Oren Raz
-
Article
| Open AccessConfocal multiview light-sheet microscopy
Multiview light-sheet microscopy is a powerful tool for imaging relatively large biological samples over long periods of time, but scattering can limit image quality. Here, the authors combine multiview light-sheet imaging with electronic confocal slit detection to improve image quality, double acquisition speed and streamline data fusion.
- Gustavo de Medeiros
- , Nils Norlin
- & Lars Hufnagel
-
Article
| Open AccessOptical focusing inside scattering media with time-reversed ultrasound microbubble encoded light
Focusing light inside biological tissue is challenging due to its strong scattering nature. Here, the authors develop a technique that uses ultrasonically destroyed microbubbles to assist in the computation of a wavefront solution which forms optical foci at the microbubble destruction sites.
- Haowen Ruan
- , Mooseok Jang
- & Changhuei Yang
-
Article
| Open AccessScattering-type scanning near-field optical microscopy with reconstruction of vertical interaction
Conventionally, scattering-type scanning near-field optical microscopy does not provide information on the vertical characteristic of near-field responses. Here, Xu et al. develop a method to reconstruct the vertical interaction response between the tip and the sample using this near-field technique.
- Le Wang
- & Xiaoji G. Xu
-
Article
| Open AccessHigh-performing nonlinear visualization of terahertz radiation on a silicon charge-coupled device
The absence of an imaging device in the low frequency terahertz range has hindered the advance of applications. Here, Shalabyet al. introduce a silicon based charge coupled device allowing the visualization of terahertz radiation in real time and at high spatial detail.
- Mostafa Shalaby
- , Carlo Vicario
- & Christoph P. Hauri
-
Article
| Open AccessTwo-photon-like microscopy with orders-of-magnitude lower illumination intensity via two-step fluorescence
Two-photon fluorescence gives a quadratic response, which improves imaging in thick samples but requires extremely intense illumination. Here, the authors describe two-step fluorescent imaging, a much lower intensity approach to quadratic excitation, via reversible photoswitchable fluorophores.
- Maria Ingaramo
- , Andrew G. York
- & George H. Patterson
-
Article
| Open AccessDeep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination
Existing single-particle tracking techniques are limited in terms of penetration depth, tracking range or temporal resolution. Here, Perilloet al. demonstrate three-dimensional particle tracking up to 200-μm depth, with 35-nm spatial localization and 50-μs resolution using multiplexed two-photon excitation.
- Evan P. Perillo
- , Yen-Liang Liu
- & Andrew K. Dunn
-
Article
| Open AccessThree-dimensional nanometre localization of nanoparticles to enhance super-resolution microscopy
Tracking and stabilizing sample drifts is crucial towards realizing nanometer resolution in superresolution microscopy; metal nanoparticles can provide drift information but diffraction remains a challenge. Here, Bonet al. combine intensity and phase information to reach three-dimensional subnanometre accuracies.
- Pierre Bon
- , Nicolas Bourg
- & Sandrine Lévêque-Fort
-
Article |
High-resolution optical spectroscopy using multimode interference in a compact tapered fibre
While desirable for compact solutions, the miniaturization of spectrometers comes at the cost of spectral resolution and operating range. Here, Wanet al. propose a tapered fibre multimode interference spectrometer exhibiting high spectral resolution from the visible to the near infrared in a compact configuration.
- Noel H. Wan
- , Fan Meng
- & Dirk Englund