Featured
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Article |
A distinct cortical code for socially learned threat
Studies in mice show that observational fear learning is encoded by neurons in the dorsomedial prefrontal cortex in a manner that is distinct from the encoding of fear learned by direct experience.
- Shana E. Silverstein
- , Ruairi O’Sullivan
- & Andrew Holmes
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Cortical reactivations predict future sensory responses
Offline cortical reactivations predict the gradual drift and separation in sensory cortical response patterns and may enhance sensory discrimination.
- Nghia D. Nguyen
- , Andrew Lutas
- & Mark L. Andermann
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Article
| Open AccessA high-performance speech neuroprosthesis
A speech-to-text brain–computer interface that records spiking activity from intracortical microelectrode arrays enabled an individual who cannot speak intelligibly to achieve 9.1 and 23.8% word error rates on a 50- and 125,000-word vocabulary, respectively.
- Francis R. Willett
- , Erin M. Kunz
- & Jaimie M. Henderson
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Article
| Open AccessLearnable latent embeddings for joint behavioural and neural analysis
A new encoding method, CEBRA, jointly uses behavioural and neural data in a (supervised) hypothesis- or (self-supervised) discovery-driven manner to produce both consistent and high-performance latent spaces.
- Steffen Schneider
- , Jin Hwa Lee
- & Mackenzie Weygandt Mathis
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Emergent reliability in sensory cortical coding and inter-area communication
The mouse neocortex supports sensory performance through transient increases in sensory coding redundancy, neural codes that are robust to cellular variability, and inter-area fluctuation modes that transmit sensory data and task responses in non-interfering channels.
- Sadegh Ebrahimi
- , Jérôme Lecoq
- & Mark J. Schnitzer
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Article |
Cortical ensembles orchestrate social competition through hypothalamic outputs
Analyses of neural activity of mice competing in a social competition assay monitored by a computer vision tool reveal a neural circuit with a role in dynamically modulating social dominance.
- Nancy Padilla-Coreano
- , Kanha Batra
- & Kay M. Tye
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Article |
Decoding and perturbing decision states in real time
In macaque motor cortex, moment-to-moment fluctuations in neurally derived decision variables are tightly linked to decision state and predict behavioural choices with better accuracy than condition-averaged decision variables or the visual stimulus alone, and can be used to distinguish between different models of decision making.
- Diogo Peixoto
- , Jessica R. Verhein
- & William T. Newsome
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Article |
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states
In mouse models of Parkinson’s disease and dyskinesia, striatal spiny projection neurons of the direct and indirect pathways have abnormal, imbalanced levels of spontaneous and locomotor-related activity, with the two different disease states characterized by opposite abnormalities.
- Jones G. Parker
- , Jesse D. Marshall
- & Mark J. Schnitzer
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Letter |
Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex
Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.
- Ryan Remedios
- , Ann Kennedy
- & David J. Anderson
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Letter |
Encoding of action by the Purkinje cells of the cerebellum
Recording from Purkinje cells in monkeys, this study found that the combined simple-spike responses of bursting and pausing Purkinje cells, but not either population alone, predicted the real-time speed of saccades; moreover, when Purkinje cells were organized according to their complex-spike field, the population responses encoded both speed and direction of the eye during saccades via a gain field.
- David J. Herzfeld
- , Yoshiko Kojima
- & Reza Shadmehr
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Research Highlights |
Neuroscience: Movement decoded