Molecularly targeted therapy
A molecularly targeted therapy is designed to specifically modulate the function of a protein or other cellular component linked to a particular disease; for example, specific inhibitors of protein kinase involved in cell proliferation are used to treat some cancers. Such therapies may often be used with companion diagnostics to identify patients that are most likely to respond favourably.
Latest Research and Reviews
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Research
| Open Access
An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies
Experimental & Molecular Medicine 54, 1850-1861 -
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Nilotinib efficacy and safety as salvage treatment following imatinib intolerance and/or inefficacy in steroid refractory chronic graft-versus-host-disease (SR-cGVHD): a prospective, multicenter, phase II study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
The natural product salicin alleviates osteoarthritis progression by binding to IRE1α and inhibiting endoplasmic reticulum stress through the IRE1α-IκBα-p65 signaling pathway
An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies
Therapeutic advances in COVID-19
Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome
Pirtobrutinib inhibits wild-type and mutant Bruton’s tyrosine kinase-mediated signaling in chronic lymphocytic leukemia
Managing RAAS inhibitor use in advanced CKD
Targeting perivascular S1P attenuates inflammation
Implementing precision medicine in a regionally organized healthcare system in Sweden