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| Open AccessA bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity
- Francesc Rabanal
- , Ariadna Grau-Campistany
- & Yolanda Cajal
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| Open AccessNew ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity
- Qiu-Yue Qi
- , Er-Wei Li
- & Hong-Wei Liu
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| Open AccessMultiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease
- Fang Luo
- , Jiangyong Gu
- & Xiaojie Xu
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| Open AccessA novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
- Octavian Bucur
- , Gabriel Gaidos
- & Roya Khosravi-Far
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| Open AccessTubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity
- Wei Zhao
- , Jia-Ke Bai
- & Ya-Jie Tang
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| Open AccessStructure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking
- Margherita Brindisi
- , Simone Brogi
- & Giuseppe Campiani
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| Open AccessDesign, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors
- Rubén Ferreira
- , Jesper R. Nilsson
- & Morten Grøtli
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| Open AccessSmall Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations
- Chantelle J. Capicciotti
- , Jayme D. R. Kurach
- & Robert N. Ben
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| Open AccessKRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines
- João Lavrado
- , Hugo Brito
- & Alexandra Paulo
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| Open AccessPalladium-Mediated Dealkylation of N-Propargyl-Floxuridine as a Bioorthogonal Oxygen-Independent Prodrug Strategy
- Jason T. Weiss
- , Neil O. Carragher
- & Asier Unciti-Broceta
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| Open AccessRuthenium Polypyridyl Complex Inhibits Growth and Metastasis of Breast Cancer Cells by Suppressing FAK signaling with Enhancement of TRAIL-induced Apoptosis
- Wenqiang Cao
- , Wenjie Zheng
- & Tianfeng Chen
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| Open AccessApoptotic effect of novel Schiff Based CdCl2(C14H21N3O2) complex is mediated via activation of the mitochondrial pathway in colon cancer cells
- Maryam Hajrezaie
- , Mohammadjavad Paydar
- & Mahmood Ameen Abdulla
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| Open AccessProlonged-acting, Multi-targeting Gallium Nanoparticles Potently Inhibit Growth of Both HIV and Mycobacteria in Co-Infected Human Macrophages
- Prabagaran Narayanasamy
- , Barbara L. Switzer
- & Bradley E. Britigan
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| Open AccessHomo-β-amino acid containing MBP(85–99) analogs alleviate experimental autoimmune encephalomyelitis
- Ravi Kant
- , Shweta Pasi
- & Avadhesha Surolia
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| Open AccessRationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease
- K. Rajasekhar
- , S. N. Suresh
- & T. Govindaraju
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| Open AccessResidues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1
- Xianqiang Sun
- , Jianxin Cheng
- & Yaoquan Tu
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| Open AccessCloud computing approaches for prediction of ligand binding poses and pathways
- Morgan Lawrenz
- , Diwakar Shukla
- & Vijay S. Pande
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| Open AccessA potent tumoricidal co-drug ‘Bet-CA’ - an ester derivative of betulinic acid and dichloroacetate selectively and synergistically kills cancer cells
- Suchandrima Saha
- , Monisankar Ghosh
- & Samir Kumar Dutta
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| Open AccessSynthesis and discovery of 18α-GAMG as anticancer agent in vitro and in vivo via down expression of protein p65
- Wen-jian Tang
- , Yong-an Yang
- & Xin-hua Liu
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Article
| Open AccessUltrafast High-Resolution Mass Spectrometric Finger Pore Imaging in Latent Finger Prints
- Christian Elsner
- & Bernd Abel
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| Open AccessUrinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity
- Aihua Zhang
- , Hui Sun
- & Xijun Wang
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| Open AccessA crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs
- Tian Liu
- , Peng Guo
- & Qing Yang
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| Open AccessProtective Effect of Aframomum melegueta phenolics Against CCl4-Induced Rat Hepatocytes Damage; Role of Apoptosis and Pro-inflammatory Cytokines inhibition
- Ali M. El-Halawany
- , Riham Salah El Dine
- & Masao Hattori
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| Open AccessRational design and validation of a Tip60 histone acetyltransferase inhibitor
- Chunxia Gao
- , Emer Bourke
- & James A. L. Brown
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| Open Access2′-Epi-uscharin from the Latex of Calotropis gigantea with HIF-1 Inhibitory Activity
- Supawadee Parhira
- , Guo-Yuan Zhu
- & Zhi-Hong Jiang
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| Open AccessApoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma
- Simona Daniele
- , Sabrina Taliani
- & Claudia Martini
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| Open AccessChemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillusreuteri
- Philip T. Cherian
- , Xiaoqian Wu
- & Julian G. Hurdle
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| Open AccessCommon Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins
- Shichao Yu
- , Jewn Giew Park
- & Yuan-Ping Pang
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| Open AccessStructural basis for a class of nanomolar influenza A neuraminidase inhibitors
- Philip S. Kerry
- , Sankar Mohan
- & B. Mario Pinto
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| Open AccessInduction of Pax3 gene expression impedes cardiac differentiation
- Qiao Li
- , Melanie Le May
- & Jihong Chen
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| Open AccessDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
- Qing-Hua Hu
- , Ru-Juan Liu
- & En-Duo Wang
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| Open AccessTwo mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group
- Weiping Liu
- , Jia Su
- & Yan Li
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| Open AccessSynthesis and characterization of a new class of anti-angiogenic agents based on ruthenium clusters
- Alexey A. Nazarov
- , Mathurin Baquié
- & Paul J. Dyson
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| Open AccessThe embalmed heart of Richard the Lionheart (1199 A.D.): a biological and anthropological analysis
- Philippe Charlier
- , Joël Poupon
- & Geoffroy Lorin de la Grandmaison
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| Open AccessPost-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly
- Shiori Toba
- , Yasuhisa Tamura
- & Shinji Hirotsune
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| Open AccessNovel Selective and Irreversible Mosquito Acetylcholinesterase Inhibitors for Controlling Malaria and Other Mosquito-Borne Diseases
- Dengfeng Dou
- , Jewn Giew Park
- & Yuan-Ping Pang
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| Open AccessDiscovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity
- Natalia Realini
- , Carlos Solorzano
- & Daniele Piomelli
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| Open AccessDNA based identification of medicinal materials in Chinese patent medicines
- Rong Chen
- , Juan Dong
- & Zhuo Tang
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| Open AccessDiosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
- Chihiro Tohda
- , Takuya Urano
- & Tomoharu Kuboyama
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| Open AccessOxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics
- Tetsu Hirosawa
- , Mitsuru Kikuchi
- & Yoshio Minabe
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| Open AccessGalantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome
- Fabio M. Simoes de Souza
- , Nicolas Busquet
- & Diego Restrepo
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| Open AccessAn N-methyl-d-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement
- Kenichi Kuriyama
- , Motoyasu Honma
- & Yoshiharu Kim
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| Open AccessMolecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum
- Tomonobu Umeda
- , Nobutada Tanaka
- & Kazuo T. Nakamura