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| Open AccessInvestigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks
- Joris Pauty
- , Marie-France Côté
- & Sébastien Fortin
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| Open AccessInhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis
- Siu Wai Tsang
- , Yi-Fu Guan
- & Hong-Jie Zhang
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| Open AccessPhotodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand
- Rachel E. Doherty
- , Igor V. Sazanovich
- & Helen E. Bryant
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| Open AccessStructure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc
- Chen Yu
- , Xiaogang Niu
- & Luhua Lai
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| Open AccessEvaluation of the antinociceptive activities of enaminone compounds on the formalin and hot plate tests in mice
- Willias Masocha
- , Samuel B. Kombian
- & Ivan O. Edafiogho
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| Open AccessDiscovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease
- Tao Su
- , Tianhua Zhang
- & Hai-Bin Luo
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| Open AccessImprovement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery
- Giulia Vignaroli
- , Pierpaolo Calandro
- & Maurizio Botta
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| Open AccessThe cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways
- Carmen del Río
- , Carmen Navarrete
- & Eduardo Muñoz
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| Open AccessMetabolism and Disposition of Aditoprim in Swine, Broilers, Carp and Rats
- Liye Wang
- , Lingli Huang
- & Zonghui Yuan
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| Open AccessNew α-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434
- Zhengbo Chen
- , Jiejie Hao
- & Weiming Zhu
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| Open AccessTSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
- Barbara Costa
- , Eleonora Da Pozzo
- & Claudia Martini
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| Open AccessExtraction, purification and anti-fatigue activity of γ-aminobutyric acid from mulberry (Morus alba L.) leaves
- Hengwen Chen
- , Xuanhui He
- & Jie Wang
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| Open AccessMolecular switches of the κ opioid receptor triggered by 6′-GNTI and 5′-GNTI
- Jianxin Cheng
- , Xianqiang Sun
- & Yun Tang
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| Open AccessInsights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists
- Valentina Sepe
- , Carmen Festa
- & Angela Zampella
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| Open AccessPotential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights
- Priyanka Singh
- , Ramesha H. Jayaramaiah
- & Ashok P. Giri
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| Open AccessAn Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces
- Masakazu Nakadai
- , Shuta Tomida
- & Kazuhisa Sekimizu
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| Open AccessArchitecture of high-affinity unnatural-base DNA aptamers toward pharmaceutical applications
- Ken-ichiro Matsunaga
- , Michiko Kimoto
- & Ichiro Hirao
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| Open AccessA Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins
- Domenico Azarnia Tehran
- , Giulia Zanetti
- & Marco Pirazzini
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| Open AccessThe Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions
- Jiahn-Haur Liao
- , Tzu-Hua Wu
- & Shih-Hsiung Wu
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| Open AccessFluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells
- Wei Zhao
- , Yong Yang
- & Ya-Jie Tang
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| Open AccessEnteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route
- Masahiro Murakami
- , Kazutaka Nishina
- & Takanori Yokota
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| Open AccessDistinctive effect on nerve growth factor-induced PC12 cell neurite outgrowth by two unique neolignan enantiomers from Illicium merrillianum
- Xinhui Tian
- , Rongcai Yue
- & Weidong Zhang
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| Open AccessInsight into 2α-Chloro-2′(2′,6′)-(Di)Halogenopicropodophyllotoxins Reacting with Carboxylic Acids Mediated by BF3·Et2O
- Lingling Fan
- , Xiaoyan Zhi
- & Hui Xu
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| Open AccessStructure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism
- Francesco Saverio Di Leva
- , Carmen Festa
- & Vittorio Limongelli
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| Open AccessTargeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily
- Valentina Gandin
- , Alessandro Ferrarese
- & Giovanni Marzaro
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| Open AccessDiscovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays
- Mingyun Shen
- , Sheng Tian
- & Tingjun Hou
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| Open AccessA novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase
- Yingying Zuo
- , Yanxia Shi
- & Zhengying Pan
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| Open AccessGlaucumolides A and B, Biscembranoids with New Structural Type from a Cultured Soft Coral Sarcophyton glaucum
- Chiung-Yao Huang
- , Ping-Jyun Sung
- & Jyh-Horng Sheu
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| Open AccessNMR characterization of HIV-1 reverse transcriptase binding to various non-nucleoside reverse transcriptase inhibitors with different activities
- Ratsupa Thammaporn
- , Maho Yagi-Utsumi
- & Supa Hannongbua
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| Open AccessEndogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments
- Mariano Stornaiuolo
- , Agostino Bruno
- & Ettore Novellino
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| Open AccessThe identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling
- Wei Hong
- , Yu Wang
- & Hao Wang
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| Open AccessStructural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization
- Jia-Lin Jia
- , Young-Hyun Han
- & Suk Namgoong
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| Open AccessDiscovery of Novel Anti-prion Compounds Using In Silico and In Vitro Approaches
- Jae Wook Hyeon
- , Jiwon Choi
- & Jeongmin Lee
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| Open AccessRational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity
- Shiliang Li
- , Guoqin Luan
- & Honglin Li
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| Open AccessAzobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner
- Zhiping Xu
- , Lina Shi
- & Zhong Li
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| Open AccessSelective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants
- Kasper Harpsøe
- , Vignir Isberg
- & David E. Gloriam
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Article
| Open AccessDiscovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors
- Juan Sun
- , Xin-Yi Wang
- & Hai-Liang Zhu
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| Open AccessDiscovery of a selective, safe and novel anti-malarial compound with activity against chloroquine resistant strain of Plasmodium falciparum
- Ankita Agarwal
- , Sarvesh Paliwal
- & Sarika Gunjan
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| Open AccessA novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells
- Huan He
- , Dong-Wei Li
- & Yi Liu
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| Open AccessFormation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity
- Wen Zhang
- , Min Chen
- & Yan Xu
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| Open AccessBA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS
- Shixuan Zhang
- , Yongming Bao
- & Qingyu Fan
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| Open AccessOne-Step Synthesis of Chiral Oxindole-type Analogues with Potent Anti-inflammatory and Analgesic Activities
- Yulong Sun
- , Jia Liu
- & Rui Wang
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| Open AccessCoumarin derivatives from Ainsliaea fragrans and their anticoagulant activity
- Liang Lei
- , Yong-bo Xue
- & Yong-hui Zhang
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Article
| Open AccessDiscovery of γ-Mangostin as an Amyloidogenesis Inhibitor
- Takeshi Yokoyama
- , Mitsuharu Ueda
- & Mineyuki Mizuguchi
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Article
| Open AccessInhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design
- Qinchang Zhu
- , Tran Hai Bang
- & Kuniyoshi Shimizu
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Article
| Open AccessLess is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1
- Rilei Yu
- , Victoria A. L. Seymour
- & David J. Craik
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| Open AccessSynthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives
- Lan-Xiang Liu
- , Xue-Quan Wang
- & Xiao-Dong Yang
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| Open AccessDesign of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold
- Yen-Hua Huang
- , Sónia T. Henriques
- & David J. Craik
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| Open AccessChemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats
- Maryam Hajrezaie
- , Keivan Shams
- & Mahmood Ameen Abdulla