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| Open AccessPeptidomimetics Based On Dehydroepiandrosterone Scaffold: Synthesis, Antiproliferation Activity, Structure-Activity Relationship, and Mechanisms
- Xiaohui Wang
- , Haihuan Su
- & Xiufang Cao
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| Open AccessSupport vector regression-guided unravelling: antioxidant capacity and quantitative structure-activity relationship predict reduction and promotion effects of flavonoids on acrylamide formation
- Mengmeng Huang
- , Yan Wei
- & Yu Zhang
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| Open AccessSpiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification
- Santanu Hati
- , Sayantan Tripathy
- & Subhabrata Sen
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| Open AccessSite-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection
- Chao Wang
- , Xue Li
- & Keliang Liu
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| Open AccessPruinosanones A-C, anti-inflammatory isoflavone derivatives from Caragana pruinosa
- Chengjian Zheng
- , Liang Wang
- & Luping Qin
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| Open AccessThymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation
- Long Chen
- , Bing Li
- & Yinghui Chen
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| Open AccessRobust neuroprotective effects of 2-((2-oxopropanoyl)oxy)-4-(trifluoromethyl)benzoic acid (OPTBA), a HTB/pyruvate ester, in the postischemic rat brain
- Seung-Woo Kim
- , Hye-Kyung Lee
- & Ja-Kyeong Lee
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| Open AccessAntiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis
- Limin Xiang
- , Xiaomin Yi
- & Xiangjiu He
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| Open AccessBinding site elucidation and structure guided design of macrocyclic IL-17A antagonists
- Shenping Liu
- , Leslie A. Dakin
- & Atli Thorarensen
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| Open AccessStructurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanisms
- Xiao-Jing Shi
- , Bin Yu
- & Hong-Min Liu
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| Open AccessN-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes
- Mauro Carcelli
- , Dominga Rogolino
- & Lieve Naesens
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| Open AccessNovel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization
- Rajnish Kumar
- , Bengt Långström
- & Taher Darreh-Shori
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| Open AccessRapid discovery and identification of anti-inflammatory constituents from traditional Chinese medicine formula by activity index, LC-MS, and NMR
- Shufang Wang
- , Haiqiang Wang
- & Yiyu Cheng
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| Open AccessDiscovery of a new function of curcumin which enhances its anticancer therapeutic potency
- Koji Nagahama
- , Tomoya Utsumi
- & Junji Kawakami
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| Open AccessConstruction of a tunable multi-enzyme-coordinate expression system for biosynthesis of chiral drug intermediates
- Wei Jiang
- & Baishan Fang
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| Open AccessStructure-Activity Analysis of Gram-positive Bacterium-producing Lasso Peptides with Anti-mycobacterial Activity
- Junji Inokoshi
- , Nobuhiro Koyama
- & Hiroshi Tomoda
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| Open AccessThe discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification
- Ying Wang
- , Yang Cao
- & Yi Zhun Zhu
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| Open AccessMultibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme
- Noelia Ferruz
- , Gary Tresadern
- & Gianni De Fabritiis
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Article
| Open AccessOxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position
- Dina Tolan
- , Valentina Gandin
- & Andrea Erxleben
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| Open AccessNavigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands
- Claudia Finamore
- , Carmen Festa
- & Angela Zampella
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| Open AccessProgrammed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor
- Weon Sup Shin
- , Jiyou Han
- & Jong Seung Kim
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| Open AccessSynthetic small molecule GLP-1 secretagogues prepared by means of a three-component indole annulation strategy
- Oleg G. Chepurny
- , Colin A. Leech
- & George G. Holz
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| Open AccessFunction-specific virtual screening for GPCR ligands using a combined scoring method
- Albert J. Kooistra
- , Henry F. Vischer
- & Chris de Graaf
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| Open AccessIntestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect
- Hua Cao
- , Zhi-Xiang Chen
- & Jian-Hua Shen
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| Open AccessLeach-proof magnetic thrombolytic nanoparticles and coatings of enhanced activity
- Andrey S. Drozdov
- , Vasiliy V. Vinogradov
- & Vladimir V. Vinogradov
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| Open AccessScreening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin
- Roberta Montanari
- , Davide Capelli
- & Giorgio Pochetti
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| Open AccessPharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy
- Chia-Hsien Wu
- , Li-Yuan Bai
- & Jing-Ru Weng
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| Open AccessModulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- Arvinder Kapur
- , Mildred Felder
- & Manish S. Patankar
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| Open AccessDesign, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors
- Bing Yang
- , Yu-Shun Yang
- & Hai-Liang Zhu
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| Open AccessNew Highly Oxygenated Germacranolides from Carpesium divaricatum and their Cytotoxic Activity
- Tao Zhang
- , Jin-Guang Si
- & Zhong-Mei Zou
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| Open AccessDiscovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae
- Ulrike Grienke
- , Martina Richter
- & Judith M. Rollinger
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| Open AccessSmall molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain
- Patrick Kanju
- , Yong Chen
- & Wolfgang B. Liedtke
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| Open AccessExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study
- Guoxun Zheng
- , Weiwei Xue
- & Feng Zhu
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| Open AccessFirst-in-class small molecule potentiators of cancer virotherapy
- Mark H. Dornan
- , Ramya Krishnan
- & Christopher N. Boddy
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| Open AccessIdentification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors
- Rajinikanth Mamidala
- , Papiya Majumdar
- & Subhabrata Sen
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| Open AccessInhibition of gold nanoparticles (AuNPs) on pathogenic biofilm formation and invasion to host cells
- Qilin Yu
- , Jianrong Li
- & Mingchun Li
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| Open AccessAn inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
- Meng-Chen Lu
- , Jian-Ai Ji
- & Zheng-Yu Jiang
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| Open AccessDesign and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1H-Imidazole
- Romeo Romagnoli
- , Pier Giovanni Baraldi
- & Giampietro Viola
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| Open AccessInhibiting complex IL-17A and IL-17RA interactions with a linear peptide
- Shenping Liu
- , Joel Desharnais
- & Lauren D. Wood
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| Open AccessA platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors
- Yuming Wei
- , Daniel C. Poon
- & Kenneth K. W. To
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| Open AccessDesign, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents
- Yong-Tao Duan
- , Ruo-Jun Man
- & Hai-Liang Zhu
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| Open AccessDiscovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury
- Yali Zhang
- , Jianzhang Wu
- & Guang Liang
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| Open AccessBioactivity Focus of α-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors
- Laitao Zhang
- , Yi-Fang Li
- & Heru Chen
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| Open AccessReceptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
- Vernon Seow
- , Junxian Lim
- & David P. Fairlie
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| Open AccessBioorthogonal two-component drug delivery in HER2(+) breast cancer mouse models
- Sudath Hapuarachchige
- , Yoshinori Kato
- & Dmitri Artemov
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| Open AccessUltrasound-promoted two-step synthesis of 3-arylselenylindoles and 3-arylthioindoles as novel combretastatin A-4 analogues
- Zhiyong Wen
- , Xiaona Li
- & Weige Zhang
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Article
| Open AccessMolecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands
- Gerolamo Vettoretti
- , Elisabetta Moroni
- & Giorgio Colombo
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| Open AccessOne-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazoles
- Buchi Reddy Vaddula
- , Mukund P. Tantak
- & Dalip Kumar
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| Open AccessSmall molecule-mediated up-regulation of microRNA targeting a key cell death modulator BNIP3 improves cardiac function following ischemic injury
- Se-Yeon Lee
- , Seahyoung Lee
- & Ki-Chul Hwang