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Open Access
Featured
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Outlook |
Bioglue breakthrough
A nature-inspired adhesive offers hope for wound healing and haemorrhage control.
- Elie Dolgin
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Clinical Briefing |
A digital bridge between brain and spinal cord restores walking after paralysis
Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, enabling an individual with spinal-cord injury to walk naturally.
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News |
Brain–spine interface allows paralysed man to walk using his thoughts
The device provides a connection between the brain and spinal cord, allowing thought to control movement.
- Dyani Lewis
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News |
Game-changing obesity drugs go mainstream: what scientists are learning
Studies tackle who’s most likely to lose weight on the new generation of anti-obesity medications.
- Mariana Lenharo
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News |
Why is COVID life-threatening for some people? Genetics study offers clues
Immune genes could play a part in the risk of needing intensive care when infected with SARS-CoV-2.
- Heidi Ledford
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Article
| Open AccessGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).
- Erola Pairo-Castineira
- , Konrad Rawlik
- & J. Kenneth Baillie
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Correspondence |
Chronic pain: try new routes to more tailored treatments
- Pablo R. Brumovsky
- , Mariano Asla
- & Marcelo J. Villar
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News |
Menopause therapy: Brain-based treatment for hot flushes approved by FDA
Investigations into the impact of menopause on the brain have yielded a potential way to treat troublesome symptoms without hormones.
- Heidi Ledford
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Career Q&A |
How my training helps me to address health disparities in multiple myeloma
Irene Ghobrial’s research on early detection of this type of bone-marrow cancer aims to improve patient outcomes, especially among African Americans.
- Frances Gatta
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News & Views |
Vaccine boosts T cells that target pancreatic tumours
Efforts to tackle pancreatic cancer by harnessing immune cells have had limited success. A clinical trial reports promising results from testing a personalized approach to boosting immune responses to such tumours.
- Amanda L. Huff
- & Neeha Zaidi
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News & Views |
Molecular basis for muscle loss that causes cachexia
Muscle loss during chronic disease is a life-threatening condition for which there is no effective treatment. The identification of an underlying molecular mechanism might offer new therapeutic targets.
- Laura Antonio-Herrera
- & Andreas Bergthaler
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News Feature |
‘I am not a broken version of normal’ — autistic people argue for a stronger voice in research
Despite broader acceptance of neurodiversity, autistic advocates and scientists are still fighting for a chance to set clinical and scientific priorities.
- Emiliano Rodríguez Mega
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News & Views |
How thought itself can drive tumour growth
Tumour cells can form connections with neurons in the brain. Examination of a variety of types of evidence concerning human brain cancer sheds light on how these tumour–neuron interactions affect cognition and survival times.
- George M. Ibrahim
- & Michael D. Taylor
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News Feature |
How menopause reshapes the brain
Researchers are starting to learn how the early stages of menopause affect brain health — and what that could mean for treatment.
- Heidi Ledford
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News Feature |
Women’s health research lacks funding — these charts show how
Conditions that affect women more than men garner less funding. But boosting investment could reap big rewards.
- Kerri Smith
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Nature Podcast |
Menopause and women’s health: why science needs to catch up
A focus on women’s health research, and the star caught in the act of devouring a planet.
- Nick Petrić Howe
- & Shamini Bundell
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Correspondence |
African American genomes don’t capture Africa’s genetic diversity
- Segun Fatumo
- & Ananyo Choudhury
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Correspondence |
Strengthen scientific review of research protocols
- John H. Powers
- , Jie Min
- & David Tribble
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News |
US cancer deaths are falling — but not fast enough
Models show that death rates must decline faster to meet Cancer Moonshot goals to cut deaths in half in 25 years.
- Heidi Ledford
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Research Highlight |
An easy-to-swallow pill monitors X-ray dosage
Device could enable doctors to calibrate the treatment of people receiving radiotherapy for certain tumours.
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News & Views |
Enzyme lights dual fires to promote cancer
Tumours with certain cancer-driving mutations are difficult to treat. A discovery that one enzyme both controls proliferation and suppresses anticancer immune defences presages the exploration of new cancer-therapy strategies.
- Anghesom Ghebremedhin
- & Judith A. Varner
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Outlook |
Kids and clinical trials: why the system is failing children
A panel of physicians and researchers discusses the reasons for the paucity of trials, the effect it has on patients and how the approval process for paediatric drugs could be streamlined.
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News & Views |
Molecular portraits of lung cancer evolution
Assessing the genetic and cellular changes that underlie human lung cancer as it evolves could aid the development of treatments. The TRACERx project reports data from studies tracking the disease.
- Tikvah K. Hayes
- & Matthew Meyerson
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News & Views |
Extrachromosomal DNA appears before cancer forms
A type of circular DNA called extrachromosomal DNA was thought to be found exclusively in cancer. Its discovery in non-cancerous tissue suggests that it might have an early active role in malignant transformation.
- David H. Wang
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Article
| Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and relationships between intratumour heterogeneity and clinical outcome.
- Alexander M. Frankell
- , Michelle Dietzen
- & Charles Swanton
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Correspondence |
NIH funding: hone efforts to tackle structural racism
- Adesuwa Akhetuamhen
- , Eseosa T. Ighodaro
- & Renee Hsia
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News & Views |
From the archive: new words to describe human–machine relationships, and a demonstration of the perceptual abilities of butterflies
Snippets from Nature’s past.
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Article |
Surveillance of SARS-CoV-2 at the Huanan Seafood Market
- William J. Liu
- , Peipei Liu
- & Guizhen Wu
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News & Views |
Air pollution’s role in the promotion of lung cancer
Air pollution is associated with the development of lung cancer. Analysis of clinical samples and mouse cancer models suggests that inflammation and a tumour-promotion process induced by polluted air are the major culprits.
- Allan Balmain
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Article
| Open AccessBlinded, randomized trial of sonographer versus AI cardiac function assessment
The impact of artificial intelligence in cardiac function assessment is evaluated by a blinded, randomized non-inferiority trial of artificial intelligence versus sonographer initial assessment of the left ventricular ejection fraction.
- Bryan He
- , Alan C. Kwan
- & David Ouyang
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Article |
Lung adenocarcinoma promotion by air pollutants
Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer
- William Hill
- , Emilia L. Lim
- & Charles Swanton
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News |
How virtual models of the brain could transform epilepsy surgery
An ongoing clinical trial aims to test whether digital models built using brain-scan data can help to identify where seizures originate.
- Miryam Naddaf
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Research Highlight |
High-precision genomic tool tackles deadly mutation
Genome editing raises levels of a protein that is scarce in people with spinal muscular atrophy.
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News & Views |
Severe hepatitis outbreak in children linked to AAV2 virus
Since 2022, more than 1,000 cases of childhood hepatitis with no known cause have been reported. The discovery of adeno-associated virus 2 in the blood and livers of such children might provide an explanation.
- Frank Tacke
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Article
| Open AccessGenomic investigations of unexplained acute hepatitis in children
An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.
- Sofia Morfopoulou
- , Sarah Buddle
- & Judith Breuer
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Article |
Adeno-associated virus type 2 in US children with acute severe hepatitis
A retrospective analysis using PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing finds an association between adeno-associated virus type 2 and paediatric hepatitis of unknown cause.
- Venice Servellita
- , Alicia Sotomayor Gonzalez
- & Charles Y. Chiu
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Outline |
Video: Safeguarding the kidney
Physicians aim to find better ways to prevent, diagnose and treat acute kidney injury.
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Outline |
What is acute kidney injury? A visual guide
Early detection and prompt treatment could prevent long-term health effects of acute kidney injury, a condition that commonly arises while people are in hospital.
- Michael Eisenstein
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Outline |
Preventing kidney injuries in hospital
Delayed diagnosis and limited treatment options leave people with acute kidney injury at risk of long-term health problems. Researchers are now looking for ways to act earlier and more effectively.
- Michael Eisenstein
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Editorial |
Treat pain as a priority, not an afterthought
Chronic pain is real and ruins lives — medical attitudes to it must change.
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News & Views |
A metabolic vulnerability of pancreatic cancer
Unusual metabolic pathways used by cancer cells offer possible targets for the development of clinical treatments. One such pathway, involving molecules called polyamines, has been found for pancreatic cancer.
- Daniel J. Puleston
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Article
| Open AccessDiminishing benefits of urban living for children and adolescents’ growth and development
The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.
- Anu Mishra
- , Bin Zhou
- & Majid Ezzati
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News Feature |
Chronic pain can be treated — so why are millions still suffering?
Science is beginning to uncover the multiple processes driving persistent pain. But connecting people with treatments that will help them remains a challenge.
- Lucy Odling-Smee
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Research Highlight |
Gene editing holds promise for babies with deadly immune disease
Repairs to DNA allow stem cells to develop into T cells.
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News & Views |
Cancer cells remodel nuclear actin filaments to resist chemotherapy
Cancers that arise from epithelial cells often contain tumour cells that have acquired the characteristics of another cell type — a mesenchymal cell. A mouse model of skin cancer offers insights into why such cells resist treatment.
- Stephanie Panier
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Matters Arising
| Open AccessCommon orthopaedic trauma may explain 31,000-year-old remains
- Nicholas J. Murphy
- , Joshua S. Davis
- & Zsolt J. Balogh
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Nature Podcast |
How to build a virus-proof cell
A streamlined genome makes bacteria immune to viral infection, and designing mini-MRI scanners for low- and middle-income countries.
- Shamini Bundell
- & Nick Petrić Howe
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Comment |
Five steps to make MRI scanners more affordable to the world
Fifty years since the basis of magnetic resonance imaging was published, MRI scanners remain expensive — and impractical in many countries. Here’s how we are making them smaller and less costly.
- Andrew Webb
- & Johnes Obungoloch
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Outlook |
Researchers tackle chronic kidney disease
Innovative technology and a class of drugs called SGLT2 inhibitors could help more people with this common condition.
- Herb Brody