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Molecular portraits of lung cancer evolution

Assessing the genetic and cellular changes that underlie human lung cancer as it evolves could aid the development of treatments. The TRACERx project reports data from studies tracking the disease.
  1. Tikvah K. Hayes

    1. Tikvah K. Hayes is in the Department of Medical Oncology, Dana–Farber Cancer Institute and the Department of Genetics, Harvard Medical School, Boston, Massachusetts 02142, USA, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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  2. Matthew Meyerson

    1. Matthew Meyerson is in the Department of Medical Oncology, Dana–Farber Cancer Institute and the Department of Genetics, Harvard Medical School, Boston, Massachusetts 02142, USA, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

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Profiles of human lung cancers captured over time can shed light on how individual tumours change as they progress, and such insights might help efforts to provide effective therapies. Five studies1–5 in Nature report analyses of lung cancer in the clinic, examined as part of the TRACERx —tracking cancer evolution through therapy (Rx) — project.

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Nature 616, 435-436 (2023)

doi: https://doi.org/10.1038/d41586-023-00934-0

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Competing Interests

M.M. receives research funding from Bayer and Janssen, and reports consulting for and equity in Delve Bio, Interline and Isabl, and patent licensing to and royalties from Bayer and LabCorp.

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