News Feature |
Featured
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News Feature |
Women’s health research lacks funding — these charts show how
Conditions that affect women more than men garner less funding. But boosting investment could reap big rewards.
- Kerri Smith
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Nature Podcast |
Menopause and women’s health: why science needs to catch up
A focus on women’s health research, and the star caught in the act of devouring a planet.
- Nick Petrić Howe
- & Shamini Bundell
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Correspondence |
African American genomes don’t capture Africa’s genetic diversity
- Segun Fatumo
- & Ananyo Choudhury
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Correspondence |
Strengthen scientific review of research protocols
- John H. Powers
- , Jie Min
- & David Tribble
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News |
US cancer deaths are falling — but not fast enough
Models show that death rates must decline faster to meet Cancer Moonshot goals to cut deaths in half in 25 years.
- Heidi Ledford
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Research Highlight |
An easy-to-swallow pill monitors X-ray dosage
Device could enable doctors to calibrate the treatment of people receiving radiotherapy for certain tumours.
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News & Views |
Enzyme lights dual fires to promote cancer
Tumours with certain cancer-driving mutations are difficult to treat. A discovery that one enzyme both controls proliferation and suppresses anticancer immune defences presages the exploration of new cancer-therapy strategies.
- Anghesom Ghebremedhin
- & Judith A. Varner
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Outlook |
Kids and clinical trials: why the system is failing children
A panel of physicians and researchers discusses the reasons for the paucity of trials, the effect it has on patients and how the approval process for paediatric drugs could be streamlined.
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News & Views |
Molecular portraits of lung cancer evolution
Assessing the genetic and cellular changes that underlie human lung cancer as it evolves could aid the development of treatments. The TRACERx project reports data from studies tracking the disease.
- Tikvah K. Hayes
- & Matthew Meyerson
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News & Views |
Extrachromosomal DNA appears before cancer forms
A type of circular DNA called extrachromosomal DNA was thought to be found exclusively in cancer. Its discovery in non-cancerous tissue suggests that it might have an early active role in malignant transformation.
- David H. Wang
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Article
| Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Analyses of multiregional tumour samples from 421 patients with non-small cell lung cancer prospectively enrolled to the TRACERx study reveal determinants of tumour evolution and relationships between intratumour heterogeneity and clinical outcome.
- Alexander M. Frankell
- , Michelle Dietzen
- & Charles Swanton
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Correspondence |
NIH funding: hone efforts to tackle structural racism
- Adesuwa Akhetuamhen
- , Eseosa T. Ighodaro
- & Renee Hsia
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News & Views |
From the archive: new words to describe human–machine relationships, and a demonstration of the perceptual abilities of butterflies
Snippets from Nature’s past.
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Article |
Surveillance of SARS-CoV-2 at the Huanan Seafood Market
- William J. Liu
- , Peipei Liu
- & Guizhen Wu
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News & Views |
Air pollution’s role in the promotion of lung cancer
Air pollution is associated with the development of lung cancer. Analysis of clinical samples and mouse cancer models suggests that inflammation and a tumour-promotion process induced by polluted air are the major culprits.
- Allan Balmain
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Article
| Open AccessBlinded, randomized trial of sonographer versus AI cardiac function assessment
The impact of artificial intelligence in cardiac function assessment is evaluated by a blinded, randomized non-inferiority trial of artificial intelligence versus sonographer initial assessment of the left ventricular ejection fraction.
- Bryan He
- , Alan C. Kwan
- & David Ouyang
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Article |
Lung adenocarcinoma promotion by air pollutants
Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer
- William Hill
- , Emilia L. Lim
- & Charles Swanton
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News |
How virtual models of the brain could transform epilepsy surgery
An ongoing clinical trial aims to test whether digital models built using brain-scan data can help to identify where seizures originate.
- Miryam Naddaf
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Research Highlight |
High-precision genomic tool tackles deadly mutation
Genome editing raises levels of a protein that is scarce in people with spinal muscular atrophy.
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News & Views |
Severe hepatitis outbreak in children linked to AAV2 virus
Since 2022, more than 1,000 cases of childhood hepatitis with no known cause have been reported. The discovery of adeno-associated virus 2 in the blood and livers of such children might provide an explanation.
- Frank Tacke
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Article
| Open AccessGenomic investigations of unexplained acute hepatitis in children
An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.
- Sofia Morfopoulou
- , Sarah Buddle
- & Judith Breuer
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Article |
Adeno-associated virus type 2 in US children with acute severe hepatitis
A retrospective analysis using PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing finds an association between adeno-associated virus type 2 and paediatric hepatitis of unknown cause.
- Venice Servellita
- , Alicia Sotomayor Gonzalez
- & Charles Y. Chiu
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Outline |
Video: Safeguarding the kidney
Physicians aim to find better ways to prevent, diagnose and treat acute kidney injury.
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Outline |
What is acute kidney injury? A visual guide
Early detection and prompt treatment could prevent long-term health effects of acute kidney injury, a condition that commonly arises while people are in hospital.
- Michael Eisenstein
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Outline |
Preventing kidney injuries in hospital
Delayed diagnosis and limited treatment options leave people with acute kidney injury at risk of long-term health problems. Researchers are now looking for ways to act earlier and more effectively.
- Michael Eisenstein
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Editorial |
Treat pain as a priority, not an afterthought
Chronic pain is real and ruins lives — medical attitudes to it must change.
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News & Views |
A metabolic vulnerability of pancreatic cancer
Unusual metabolic pathways used by cancer cells offer possible targets for the development of clinical treatments. One such pathway, involving molecules called polyamines, has been found for pancreatic cancer.
- Daniel J. Puleston
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Article
| Open AccessDiminishing benefits of urban living for children and adolescents’ growth and development
The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.
- Anu Mishra
- , Bin Zhou
- & Majid Ezzati
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News Feature |
Chronic pain can be treated — so why are millions still suffering?
Science is beginning to uncover the multiple processes driving persistent pain. But connecting people with treatments that will help them remains a challenge.
- Lucy Odling-Smee
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Research Highlight |
Gene editing holds promise for babies with deadly immune disease
Repairs to DNA allow stem cells to develop into T cells.
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News & Views |
Cancer cells remodel nuclear actin filaments to resist chemotherapy
Cancers that arise from epithelial cells often contain tumour cells that have acquired the characteristics of another cell type — a mesenchymal cell. A mouse model of skin cancer offers insights into why such cells resist treatment.
- Stephanie Panier
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Matters Arising
| Open AccessCommon orthopaedic trauma may explain 31,000-year-old remains
- Nicholas J. Murphy
- , Joshua S. Davis
- & Zsolt J. Balogh
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Nature Podcast |
How to build a virus-proof cell
A streamlined genome makes bacteria immune to viral infection, and designing mini-MRI scanners for low- and middle-income countries.
- Shamini Bundell
- & Nick Petrić Howe
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Comment |
Five steps to make MRI scanners more affordable to the world
Fifty years since the basis of magnetic resonance imaging was published, MRI scanners remain expensive — and impractical in many countries. Here’s how we are making them smaller and less costly.
- Andrew Webb
- & Johnes Obungoloch
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Outlook |
Researchers tackle chronic kidney disease
Innovative technology and a class of drugs called SGLT2 inhibitors could help more people with this common condition.
- Herb Brody
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Outlook |
How organoids are advancing the understanding of chronic kidney disease
Although complete human kidneys grown from scratch are many years away, organoids built from pluripotent stem cells are already helping to model the condition and suggest better treatments.
- Eric Bender
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Outlook |
Chronic kidney disease: highlights from research
Illuminating genetic risk, disrupting fibrosis and intercepting inflammation.
- Michael Eisenstein
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Article |
Co-opting signalling molecules enables logic-gated control of CAR T cells
Logic gating is used to develop a CAR T cell platform that is highly specific and allows the activity of T cells to be restricted to the encounter of two antigens, thus reducing on-target, off-tumour toxicity.
- Aidan M. Tousley
- , Maria Caterina Rotiroti
- & Robbie G. Majzner
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News |
COVID pill is first to cut short positive-test time after infection
The antiviral ensitrelvir, which is not approved in the United States, shortens symptoms in people with mild COVID and might reduce risk of long COVID — but more data are needed.
- Mariana Lenharo
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News |
What Chernobyl’s stray dogs could teach us about radiation
Multi-year project in Ukraine aims to uncover the health effects of chronic radiation exposure.
- Freda Kreier
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News & Views |
Bacterial meningitis hits an immunosuppressive nerve
Bacteria that cause meningitis have been found to stimulate nerve fibres in the brain’s meninges to release a neuropeptide molecule that dampens the response of immune cells and aids bacterial invasion of the central nervous system.
- Nagela G. Zanluqui
- & Dorian B. McGavern
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News & Views |
Fatty acids prime the lung as a site for tumour spread
The mechanisms that enable the deadly spread of cancer are not fully understood. It emerges that tumours can signal to the lung to manipulate lipids and so prime the organ to support tumour cells that subsequently spread there.
- Laura V. Pinheiro
- & Kathryn E. Wellen
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Career Feature |
Hyperauthorship: the publishing challenges for ‘big team’ science
Studies involving hundreds, even thousands, of scientists are on the rise, but how do such large groups coordinate their work?
- Bianca Nogrady
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News & Views |
A gut reaction can tune tumour fate during chemotherapy
The discovery that molecules produced by gut microorganisms can affect immune cells, and thus the success of chemotherapy for pancreatic cancer, points the way towards the use of nutritional interventions to improve outcomes.
- Le Li
- & Florencia McAllister
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Nature Podcast |
A twisting microscope that could unlock the secrets of 2D materials
How the Quantum Twisting Microscope could give a better ‘picture’ of atom thin layers, and science in Ukraine a year into Russia’s invasion.
- Shamini Bundell
- & Benjamin Thompson
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News Feature |
Your brain could be controlling how sick you get — and how you recover
Scientists are deciphering how the brain choreographs immune responses, hoping to find treatments for a range of diseases.
- Diana Kwon
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News |
FDA to require diversity plan for clinical trials
US regulatory agency makes ‘big change’ to increase the number of participants from under-represented groups in drug testing.
- Max Kozlov
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News & Views |
Drug trial for Alzheimer’s disease is a game changer
An antibody treatment reduces measurements of brain abnormalities called amyloid plaques in people with Alzheimer’s disease, and lessens clinical decline. This result will help in developing therapies to treat and prevent the disease.
- Eric M. Reiman
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Research Highlight |
How a tiny genetic change inflicts old age on young kids
Scientists identify a molecule key to the development of progeria, a lethal disease that causes hyper-accelerated ageing.