Interleukins articles within Nature

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  • Article
    | Open Access

    Binding of the PD1-IL2v immunocytokine to PD-1 and IL-2Rβγ on the same cell leads to an alternative differentiation of stem-like CD8+ T cells into better effectors rather than exhausted T cells in models of both chronic infection and cancer.

    • Laura Codarri Deak
    • , Valeria Nicolini
    •  & Pablo Umaña

  • Article
    | Open Access

    Cryo-electron microscopy structures of IL-25–IL-17RB–IL-17RA and IL-17A–IL-17RC–IL-17RA complexes show a tip-to-tip architecture, which is a key organizing principle of the IL-17 receptor family.

    • Steven C. Wilson
    • , Nathanael A. Caveney
    •  & K. Christopher Garcia

  • Article
    | Open Access

    Synthetic chimeric orthogonal IL-2 receptors that incorporate the intracellular domain of receptors for other γ-chain cytokines such as IL-9 can reroute orthogonal signalling and alter the phenotype of T cells to improve anti-tumour responses.

    • Anusha Kalbasi
    • , Mikko Siurala
    •  & K. Christopher Garcia

  • Article |

    Therapeutic administration of IL-27—serum levels of which are decreased in individuals with obesity—improves thermogenesis, protects against diet-induced obesity and ameliorates insulin resistance in mouse models of obesity.

    • Qian Wang
    • , Dehai Li
    •  & Zhinan Yin

  • Article |

    A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.

    • Daniel-Adriano Silva
    • , Shawn Yu
    •  & David Baker

  • Letter |

    Innate lymphoid cells increase the growth of mouse intestinal organoids via IL-22 production; recombinant IL-22 promotes growth of both mouse and human organoids, and promotes mouse intestinal stem cell (ISC) expansion and ISC-driven organoid growth via a STAT3-dependent pathway and independently of Paneth cells; IL-22 treatment in vivo enhances the recovery of ISCs from intestinal injury.

    • Caroline A. Lindemans
    • , Marco Calafiore
    •  & Alan M. Hanash

  • Article |

    Autoantigen-presenting dendritic cells are shown to interact with both effector and regulatory T cells, and effector-produced IL-2 activates the transcription factor STAT5 in regulatory T cells, which in turn upregulates suppressive molecules and prevents autoimmunity.

    • Zhiduo Liu
    • , Michael Y. Gerner
    •  & Ronald N. Germain

  • Letter |

    Eosinophil recruitment to the lung and intestine is regulated by type-2-innate-lymphoid-cell-derived IL-5 and IL-13; IL-5 is shown to be induced by the neuropeptide vasoactive intestinal peptide, which is known to coordinate pancreatic secretion with smooth muscle relaxation in response to feeding.

    • Jesse C. Nussbaum
    • , Steven J. Van Dyken
    •  & Richard M. Locksley

  • Letter |

    Interleukin-1β-induced disruption to endothelial stability and vascular permeability in a human in vitro model is shown to be independent of downstream nuclear factor-κB activation, relying instead on a MYD88–ARNO–ARF6 signalling cascade; inhibiting proteins involved in this pathway is shown to improve outcomes in animal models of inflammatory disease.

    • Weiquan Zhu
    • , Nyall R. London
    •  & Dean Y. Li

  • Letter |

    IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via the NLRP3 and NLRP6 inflammasomes provides an unanticipated mechanism, controlling IL-22 and thereby the development of colon cancer.

    • Samuel Huber
    • , Nicola Gagliani
    •  & Richard A. Flavell

  • Outlook |

    Asthma was once thought to be a uniform disease triggered by one type of immune cell. Researchers are now revealing the complexity of the condition and hope to hasten new drugs for forms unresponsive to steroids.

    • Amy Maxmen

  • Letter |

    The cytokine interleukin (IL)-23 has inflammatory effects on innate immune cells and can drive colitis, but the cellular and molecular pathways involved are poorly characterized. Here it is shown that bacterial-driven innate colitis involves a previously unknown population of IL-23-responsive innate leukocytes that produce IL-17 and interferon-γ. These cells may represent a target in inflammatory bowel disease.

    • Sofia Buonocore
    • , Philip P. Ahern
    •  & Fiona Powrie

  • Letter |

    Several non-haematopoietic-cell-derived cytokines, including interleukin (IL)25, have been implicated in inducing T helper 2 (TH2) cell-dependent inflammation, but their precise role has been unclear. Here, IL25 is shown to promote the accumulation of multipotent progenitor cells in gut-associated lymphoid tissue. These cells can give rise to macrophage or granulocyte lineages that promote the differentiation of TH2 cells and contribute to protective immunity against helminth infections.

    • Steven A. Saenz
    • , Mark C. Siracusa
    •  & David Artis

  • Letter |

    Here, a new type of innate effector leukocyte cell — the nuocyte — is described and characterized. It is shown that interleukin (IL)25 and IL33 drive the expansion of the nuocyte population, that these cells secrete IL13, and that they are required for protection against helminth infection.

    • Daniel R. Neill
    • , See Heng Wong
    •  & Andrew N. J. McKenzie

  • News & Views |

    TH2 growth factors, which are involved in allergy and in defence against parasites, are produced by many different cell types, including a newly identified population found in fat-associated lymph clusters in the abdomen.

    • Warren Strober

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