Infectious-disease epidemiology

The study of the incidence and spread of infectious diseases in populations over time. Host, pathogen and environmental factors are monitored to determine the dynamics of infection, the ultimate goal of which is to devise intervention strategies. Molecular methods, such as phylogenomics, can be used to accurately track pathogens.

Latest Research and Reviews

  • Research |

    The human placenta does not have a microbiota, suggesting that bacterial infection of the placenta is not a common cause of adverse pregnancy outcome, but group B Streptococcus is found in approximately 5% of placental samples.

    • Marcus C. de Goffau
    • , Susanne Lager
    • , Ulla Sovio
    • , Francesca Gaccioli
    • , Emma Cook
    • , Sharon J. Peacock
    • , Julian Parkhill
    • , D. Stephen Charnock-Jones
    •  & Gordon C. S. Smith
    Nature 572, 329-334
  • Research |

    Plasmid-encoded tet(X) genes from Escherichia coli in China confer high-level tigecycline resistance.

    • Jian Sun
    • , Chong Chen
    • , Chao-Yue Cui
    • , Yan Zhang
    • , Xiao Liu
    • , Ze-Hua Cui
    • , Xiao-Yu Ma
    • , Youjun Feng
    • , Liang-Xing Fang
    • , Xin-Lei Lian
    • , Rong-Min Zhang
    • , You-Zhi Tang
    • , Kou-Xing Zhang
    • , Han-Mian Liu
    • , Zhi-Hui Zhuang
    • , Shi-Dan Zhou
    • , Jing-Nan Lv
    • , Hong Du
    • , Bin Huang
    • , Fang-You Yu
    • , Barun Mathema
    • , Barry N. Kreiswirth
    • , Xiao-Ping Liao
    • , Liang Chen
    •  & Ya-Hong Liu
  • Research
    | Open Access

    Understanding genomic variation in Plasmodium falciparum parasites and inferring migration patterns can guide malaria elimination strategies. Using genome-wide data for 1722 parasites collected from 54 districts, the authors use identity-by-descent approaches to estimate regional parasite migration and spread of artemisinin drug resistance.

    • Amol C. Shetty
    • , Christopher G. Jacob
    • , Fang Huang
    • , Yao Li
    • , Sonia Agrawal
    • , David L. Saunders
    • , Chanthap Lon
    • , Mark M. Fukuda
    • , Pascal Ringwald
    • , Elizabeth A. Ashley
    • , Kay Thwe Han
    • , Tin Maung Hlaing
    • , Myaing M. Nyunt
    • , Joana C. Silva
    • , Kathleen E. Stewart
    • , Christopher V. Plowe
    • , Timothy D. O’Connor
    • , Shannon Takala-Harrison
    • , Harald Noedl
    • , Wasif A. Khan
    • , Paul Newton
    • , Myat P. Kyaw
    • , Nicholas J. White
    • , Arjen M. Dondorp
    • , Nicholas P. Day
    • , Charles J. Woodrow
    • , Mehul Dhorda
    • , M. Abul Faiz
    • , Rick M. Fairhurst
    • , Pharath Lim
    • , Rupam Tripura
    • , Mayfong Mayxay
    • , Ye Htut
    • , Francois Nosten
    • , Aung Pyae Phyo
    • , Sasithon Pukrittayakamee
    • , Tran Tinh Hien
    • , Nguyen Thanh Thuy Nhien
    • , Olugbenga A. Mokuolu
    • , Caterina I. Fanello
    •  & Marie A. Onyamboko
  • Research |

    Heteroresistance to multiple antibiotics is prevalent across carbapenem-resistant Enterobacteriaceae clinical isolates, but drug combinations that exploit multiple heteroresistance can be used to effectively treat multidrug-resistant infections.

    • Victor I. Band
    • , David A. Hufnagel
    • , Siddharth Jaggavarapu
    • , Edgar X. Sherman
    • , Jessie E. Wozniak
    • , Sarah W. Satola
    • , Monica M. Farley
    • , Jesse T. Jacob
    • , Eileen M. Burd
    •  & David S. Weiss
  • Research
    | Open Access

    Here, the authors quantify early gametocyte-committed ring (gc-ring) stage Plasmodium falciparum parasites in 260 malaria patients 10 days before maturation to transmissible stage V gametocytes, and show that the ratio of circulating gc-rings is positively correlated with parasitemia and negatively correlated with body temperature.

    • Miho Usui
    • , Surendra K. Prajapati
    • , Ruth Ayanful-Torgby
    • , Festus K. Acquah
    • , Elizabeth Cudjoe
    • , Courage Kakaney
    • , Jones A. Amponsah
    • , Evans K. Obboh
    • , Deepti K. Reddy
    • , Michelle C. Barbeau
    • , Lacy M. Simons
    • , Beata Czesny
    • , Sorana Raiciulescu
    • , Cara Olsen
    • , Benjamin K. Abuaku
    • , Linda E. Amoah
    •  & Kim C. Williamson

News and Comment