News Feature |
Featured
-
-
News |
Pneumococcal vaccine rolls out in developing world
Vaccine is first to be launched in rich and poor countries simultaneously.
- Anjali Nayar
-
-
-
Research Highlights |
Malaria mosquito lurks outdoors
-
Article |
Telomere dysfunction induces metabolic and mitochondrial compromise
Here it is shown that telomere dysfunction drives metabolic and mitochondrial compromise. Mice with dysfunctional telomeres activate p53, which in turn represses PGC-1α and PGC-1β, master regulators of metabolic and mitochondrial processes. This results in reduced mitochondrial mass, mitochondrial dysfunction and reduced ATP generation, impaired gluconeogenesis, cariomyopathy and increased reactive oxygen species. This telomere–p53–PGC pathway shows how telomere dysfunction may compromise organ function and contribute to age-related disorders.
- Ergün Sahin
- , Simona Colla
- & Ronald A. DePinho
-
News |
Antipsychotic drugs could shrink patients' brains
Experts say findings should not dramatically change current prescription practices.
- David Cyranoski
-
Editorial |
Tough on truth
The Global Fund should be praised for coming clean about fraud by grant recipients.
-
News |
Social science lines up its biggest challenges
'Top ten' crucial questions set research priorities for the field.
- Jim Giles
-
News |
Solution to medical mystery offers treatment hope
Mutations underlying a rare disease suggest therapeutic options for common conditions.
- Heidi Ledford
-
News Explainer |
A last push to eradicate polio
Funding gap persists as agencies and organizations attempt to wipe out the tenacious virus.
- Gayathri Vaidyanathan
-
News |
CJD diagnosis just got easier
Test for Creutzfeldt–Jakob disease raises hopes of speedier diagnosis.
- Tiffany O'Callaghan
-
News Explainer |
Death-row drug dilemma
Lack of anaesthetic used in lethal injection exposes ethics gaps in the supply chain.
- Emma Marris
-
Editorial |
What comes first?
An attempt to rework US food-safety regulations will fail without sufficient funds.
-
Books & Arts |
Epidemiology: Epidemic of panic
Autism's broad diagnosis has fuelled fears about vaccines despite no evidence for a link, finds Melvin Konner.
- Melvin Konner
-
News & Views |
A molecular memory booster
For many – if not all – of us, cognitive enhancement is desirable, but agents that would truly improve memory are hard to find. Unexpectedly, the product of an imprinted gene emerges as a promising candidate. See Article p.491
- Johannes Gräff
- & Li-Huei Tsai
-
News |
The other path
The professional science master's degree is growing in popularity but is losing its initial funding. Can it survive?
- Karen Kaplan
-
News Feature |
Central America: Panama's big ambition
Researchers in Panama suffered under a dictatorship and were overshadowed by the United States. Now the country is attempting a scientific renaissance.
- Rex Dalton
-
Article |
A critical role for IGF-II in memory consolidation and enhancement
After learning, memories are strengthened through a process called 'consolidation', which requires new gene and protein expression, rendering new information less vulnerable to disruption. Several transcription factor families are involved in this process, but many of the relevant downstream targets are unknown. Here, IGF-II, a protein typically implicated in somatic tissue growth and repair, is identified as an essential factor in memory retention. IGF-II initiates its own network of signalling cascades that can lead to synaptic potentiation and are most effective within a short time frame immediately after learning. Thus, IGF-II represents an endogenous target for potentially modulating cognitive enhancement.
- Dillon Y. Chen
- , Sarah A. Stern
- & Cristina M. Alberini
-
News |
Alzheimer's-disease probe nears approval
Imaging technique could help to resolve questions about brain plaques associated with the condition.
- Heidi Ledford
-
Research Highlights |
Ringing in the brain
-
Research Highlights |
Robo protein guide for cell transplants
-
Feature |
Funding: Researching outside the box
Open innovation offers scientists novel ways to apply their expertise — and sometimes provides much-needed cash.
- Cristina Jimenez
-
Editorial |
Smallpox should be saved
Secure virus stocks in the United States and Russia may still prove useful and should not be destroyed. A political compromise is the best way to make that happen.
-
Comment |
Get ready for the flood of fetal gene screening
Regulators, doctors and patients need to prepare for the ethical, legal and practical effects of sequencing fetal genomes from mothers' blood, says Henry T. Greely.
- Henry T. Greely
-
News & Views |
Drugs that prevent HIV infection
Two human trials investigate the efficacy of a type of antiretroviral drug — usually used to treat HIV-infected individuals — in preventing HIV infection. The results are heartening.
- Mark A. Wainberg
-
News & Views |
Catalytic detoxification
Protein engineering of an enzyme that catalytically detoxifies organophosphate compounds in the body opens up fresh opportunities in the search for therapeutic protection against nerve agents used in chemical warfare.
- Frank M. Raushel
-
News |
Cholera care fails to reach rural Haitians
Celebrations over the country's shrinking caseload need to be qualified, a new analysis shows.
- David Cyranoski
-
-
News |
Report supports embryo genetic tests in Germany
National academy recommends legalizing tests where there is risk of serious incurable disease.
- Alison Abbott
-
News |
Cholera vaccine plan splits experts
Opinion is divided over how to tackle the disease in Haiti.
- David Cyranoski
-
News |
Arsenic sinks to new depths
Groundwater overuse can push poisonous element deeper — a serious risk for countries in Southern Asia.
- Gayathri Vaidyanathan
-
News Explainer |
Is breast not best for babies?
New evidence contradicts World Health Organization breastfeeding advice.
- Natasha Gilbert
-
Editorial |
First do no harm
Simple tools to diagnose mental illness should not be offered without sound supporting evidence.
-
Comment |
Bring on the biomarkers
The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste.
- George Poste
-
News |
People prove impervious to anxiety from genetic tests
The results of direct-to-consumer tests relating to the risk of developing diseases seem easy to swallow.
- Cassandra Willyard
-
News |
Alzheimer's blood test 'most accurate' so far
The blood of patients with the brain disease contains antibodies not found in healthy people.
- Ewen Callaway
-
Obituary |
Frank Fenner (1914–2010)
A guiding light of the campaign to eradicate smallpox.
- Donald A. Henderson
-
Outlook |
Technology: A flavour of the future
Health biomarkers, smart technology and social networks are hastening an era of nutrition tailored to your individual needs but relying on information generated by the crowd.
- Arran Frood
-
News |
Disaster doctors may be using the wrong drugs
Study of Haiti earthquake victims shows most wounds infected with Gram-negative, not Gram-positive, bacteria.
- Daniel Cressey
-
Outlook |
Diversity: Of beans and genes
Several human genes involved in digestion have diverged along cultural lines. Research suggests these adaptations influence the range of foods tolerated and even certain diseases.
- Michael Eisenstein
-
Outlook |
Health: Edible advice
Diet-related illnesses are some of the biggest killers today. Can we tailor our food intake to prevent these diseases? Large international projects are underway to find out.
- Farooq Ahmed
-
News |
From battlefield to bedside
Medical research in the British military soldiers on despite defence cuts.
- Daniel Cressey
-
News |
US report sets ground rules for artificial life
Synthetic biology needs oversight not over-regulation, commission finds.
- Meredith Wadman
-
News Feature |
Epidemiology: Fear in the dust
Cancer epidemics in Turkey could hold the secret to staving off a public health disaster in North Dakota.
- Brendan Maher
-
Feature |
Public health: Food-safety sentinels
Disease outbreaks in recent years have revealed the vulnerability of food supplies. But they offer opportunities for those interested in waging war on microbes.
- Laura Cassiday
-
Technology Feature |
Interactome under construction
Developing techniques are helping researchers to build the protein interaction networks that underlie all cell functions.
- Laura Bonetta
-
News |
Baby's genome hidden in mother's blood
A complete fetal genome can be deduced from maternal DNA.
- Ewen Callaway
-
News |
Exposure to seasonal flu weakened armour against H1N1
Faulty antibodies from previous infections boosted severity of swine flu in the middle-aged.
- Janelle Weaver
-
News |
Video microscopy reveals molecules in motion
Technique tracks chemicals in living tissues without the need for fluorescent labels.
- Heidi Ledford