Health care articles within Nature

Featured

  • News Feature |

    If a camera snaps everything you eat, you can't lie about it later. That's why scientists are building high-tech gadgets to measure the human 'exposome'.

    • Brendan Borrell
  • Article |

    Here it is shown that telomere dysfunction drives metabolic and mitochondrial compromise. Mice with dysfunctional telomeres activate p53, which in turn represses PGC-1α and PGC-1β, master regulators of metabolic and mitochondrial processes. This results in reduced mitochondrial mass, mitochondrial dysfunction and reduced ATP generation, impaired gluconeogenesis, cariomyopathy and increased reactive oxygen species. This telomere–p53–PGC pathway shows how telomere dysfunction may compromise organ function and contribute to age-related disorders.

    • Ergün Sahin
    • , Simona Colla
    •  & Ronald A. DePinho
  • Editorial |

    The Global Fund should be praised for coming clean about fraud by grant recipients.

  • News Explainer |

    Funding gap persists as agencies and organizations attempt to wipe out the tenacious virus.

    • Gayathri Vaidyanathan
  • News Explainer |

    Lack of anaesthetic used in lethal injection exposes ethics gaps in the supply chain.

    • Emma Marris
  • Editorial |

    An attempt to rework US food-safety regulations will fail without sufficient funds.

  • Books & Arts |

    Autism's broad diagnosis has fuelled fears about vaccines despite no evidence for a link, finds Melvin Konner.

    • Melvin Konner
  • News & Views |

    For many – if not all – of us, cognitive enhancement is desirable, but agents that would truly improve memory are hard to find. Unexpectedly, the product of an imprinted gene emerges as a promising candidate. See Article p.491

    • Johannes Gräff
    •  & Li-Huei Tsai
  • News |

    The professional science master's degree is growing in popularity but is losing its initial funding. Can it survive?

    • Karen Kaplan
  • News Feature |

    Researchers in Panama suffered under a dictatorship and were overshadowed by the United States. Now the country is attempting a scientific renaissance.

    • Rex Dalton
  • Article |

    After learning, memories are strengthened through a process called 'consolidation', which requires new gene and protein expression, rendering new information less vulnerable to disruption. Several transcription factor families are involved in this process, but many of the relevant downstream targets are unknown. Here, IGF-II, a protein typically implicated in somatic tissue growth and repair, is identified as an essential factor in memory retention. IGF-II initiates its own network of signalling cascades that can lead to synaptic potentiation and are most effective within a short time frame immediately after learning. Thus, IGF-II represents an endogenous target for potentially modulating cognitive enhancement.

    • Dillon Y. Chen
    • , Sarah A. Stern
    •  & Cristina M. Alberini
  • Feature |

    Open innovation offers scientists novel ways to apply their expertise — and sometimes provides much-needed cash.

    • Cristina Jimenez
  • Editorial |

    Secure virus stocks in the United States and Russia may still prove useful and should not be destroyed. A political compromise is the best way to make that happen.

  • Comment |

    Regulators, doctors and patients need to prepare for the ethical, legal and practical effects of sequencing fetal genomes from mothers' blood, says Henry T. Greely.

    • Henry T. Greely
  • News & Views |

    Two human trials investigate the efficacy of a type of antiretroviral drug — usually used to treat HIV-infected individuals — in preventing HIV infection. The results are heartening.

    • Mark A. Wainberg
  • News & Views |

    Protein engineering of an enzyme that catalytically detoxifies organophosphate compounds in the body opens up fresh opportunities in the search for therapeutic protection against nerve agents used in chemical warfare.

    • Frank M. Raushel
  • News |

    Groundwater overuse can push poisonous element deeper — a serious risk for countries in Southern Asia.

    • Gayathri Vaidyanathan
  • Editorial |

    Simple tools to diagnose mental illness should not be offered without sound supporting evidence.

  • Comment |

    The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste.

    • George Poste
  • Outlook |

    Health biomarkers, smart technology and social networks are hastening an era of nutrition tailored to your individual needs but relying on information generated by the crowd.

    • Arran Frood
  • Outlook |

    Several human genes involved in digestion have diverged along cultural lines. Research suggests these adaptations influence the range of foods tolerated and even certain diseases.

    • Michael Eisenstein
  • Outlook |

    Diet-related illnesses are some of the biggest killers today. Can we tailor our food intake to prevent these diseases? Large international projects are underway to find out.

    • Farooq Ahmed
  • News |

    Medical research in the British military soldiers on despite defence cuts.

    • Daniel Cressey
  • News Feature |

    Cancer epidemics in Turkey could hold the secret to staving off a public health disaster in North Dakota.

    • Brendan Maher
  • Feature |

    Disease outbreaks in recent years have revealed the vulnerability of food supplies. But they offer opportunities for those interested in waging war on microbes.

    • Laura Cassiday
  • Technology Feature |

    Developing techniques are helping researchers to build the protein interaction networks that underlie all cell functions.

    • Laura Bonetta