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| Open AccessEpidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice
Phospholipase C is a signalling molecule with many cellular functions, but its physiological role at the organismal level is largely unknown. Kanemaruet al.show that phospholipase Cδ1 in the mouse epidermis influences interleukin and leukocyte concentrations in the blood.
- Kaori Kanemaru
- , Yoshikazu Nakamura
- & Kiyoko Fukami
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Article |
gp96 expression in neutrophils is critical for the onset of Escherichia coli K1 (RS218) meningitis
E. coliK1 can elude the innate immune system and cause neonatal meningitis. This study shows thatE. coli K1 enters polymorphonuclear leukocytes (PMNs) using gp96 to reduce the oxidative burst, and that PMN-depleted mice are resistant to E. coliK1 infection, suggesting that PMNs permit bacterial survival in the host.
- Rahul Mittal
- & Nemani V. Prasadarao