Mast cells articles within Nature Communications

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  • Article
    | Open Access

    Mast cells have been shown to be involved with rheumatoid arthritis, but the mechanisms are not clear. Here using mouse models and making association with human patients, the authors show mast cells have an important function in the pathogenesis of rheumatoid arthritis, involving regulation of T cell responses and release of mast cell mediators.

    • Yunxuan Lei
    • , Xin Guo
    •  & Guangjie Chen

  • Article
    | Open Access

    Mast cells are activated and proliferate during allergic reactions which can involve mast cell specific proteins. Here the authors show that mast cell-expressed membrane protein1 (MCEMP1) is an adaptor for KIT to promote SCF mediated mast cell proliferation and lack of MCEMP1 reduces inflammation in mouse asthma models.

    • Youn Jung Choi
    • , Ji-Seung Yoo
    •  & Jae U. Jung

  • Article
    | Open Access

    The blood vessel wall is a complex multi-layered structure, yet upon injury or infection, neutrophil leukocytes are rapidly migrating from the blood stream to the affected tissues, by a process termed diapedesis. Authors here show that the final steps of diapedesis through the outer pericyte layer is regulated by perivascular mast cells via IL-17A production.

    • Régis Joulia
    • , Idaira María Guerrero-Fonseca
    •  & Mathieu-Benoit Voisin

  • Article
    | Open Access

    Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I and CD8 T cells, and is associated with resistance to ICT, which can be reversed by c-kit inhibitor treatment.

    • Rajasekharan Somasundaram
    • , Thomas Connelly
    •  & Meenhard Herlyn

  • Article
    | Open Access

    How Japanese encephalitis virus (JEV) penetrates the blood-brain barrier (BBB) remains unclear. Here, using a genetic mouse model and a virulent JEV strain, the authors show that perivascular mast cells (MC) mediate JEV neuroinvasion and identify the MC-protease chymase as a potential therapeutic target.

    • Justin T. Hsieh
    • , Abhay P. S. Rathore
    •  & Ashley L. St. John

  • Article |

    Mast cells are major contributors to allergy. Here the authors show that prostaglandin D2-deficient mast cells produce more chemoattractants, promoting mast cell hyperplasia and exacerbating allergic responses in a mouse model of food allergy.

    • Tatsuro Nakamura
    • , Shingo Maeda
    •  & Takahisa Murata

  • Article |

    Mast cells are tissue-resident immune cells important for clearance of parasitic worms but also mediating allergic reactions. Here Joulia et al. show that human mast cells form degranulatory synapses with antibody-targeted cells and pathogens to increase efficiency and minimize off-target effects.

    • Régis Joulia
    • , Nicolas Gaudenzio
    •  & Eric Espinosa

  • Article
    | Open Access

    Activating mutations of the tyrosine kinase Kit are commonly found in mast cell neoplasms and gastrointestinal stromal tumours. Here the authors show that mutant Kit, through the activation of PI3K and STAT3 pathways, elicits proliferative and survival signals from endolysosomes and from the endoplasmic reticulum.

    • Yuuki Obata
    • , Shota Toyoshima
    •  & Ryo Abe

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