Basophils articles within Nature Communications

Featured

• Article
  22 April 2024 | Open Access

  PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

  Basophils have been implicated in systemic lupus erythematosus (SLE), as evidenced by the fact that basophil-deficient mice do not develop the disease. Here, the authors demonstrate that PD-L1 and IL-4 expression in basophils promotes the pathogenic accumulation of follicular helper T cells in patients with SLE and murine models.

  • John TCHEN
  • , Quentin SIMON
  •  & Nicolas CHARLES

• Article
  18 May 2023 | Open Access

  Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils

  Single cell sequencing can be used to better characterize immune cell progenitors. Here the authors characterize CLEC12A^hi pre-basophils downstream of pre-basophil and mast cell progenitors (pre-BMPs) but upstream of mature basophils and this population includes basophil progenitors (BaPs).

  • Kensuke Miyake
  • , Junya Ito
  •  & Hajime Karasuyama

• Article
  23 April 2013 | Open Access

  Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

  Both dendritic cells and basophils have been shown to influence T helper 2 cell induction, however the relative importance of their roles remains unclear. Otsuka et al. find that basophils present hapten and peptide antigens to T cells, but are unable to present protein antigens in the absence of dendritic cells.

  • Atsushi Otsuka
  • , Saeko Nakajima
  •  & Kenji Kabashima