Genetics

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

Featured

News & Views | 18 January 2023

The role of the genome regulatory network in heart failure

Nature Cardiovascular Research 2, 16-17
News & Views | 17 January 2023

Fast-evolving genomic regions underlie human brain development
- Eucharist Kun
- & Vagheesh M. Narasimhan
Nature
News & Views | 17 January 2023

Chilling stress and loss of an exonuclease lead to biparental inheritance of plastids

Nature Plants 9, 9-10

Latest Research and Reviews

Research
28 January 2023 | Open Access

Maternal diet induces persistent DNA methylation changes in the muscle of beef calves
- Rocío Amorín
- , Lihe Liu
- & Francisco Peñagaricano
Scientific Reports 13, 1587
Research
28 January 2023 | Open Access

The function and evolution of a genetic switch controlling sexually dimorphic eye differentiation in honeybees

Sexual dimorphism results in widely diverse animal forms, but sexual determination is generally attributed to a single gene in animal models. Here they find that the glu gene regulates sexual dimorphism of honeybee eyes, demonstrating diversification of genetic programs for dimorphism.
- Oksana Netschitailo
- , Yidong Wang
- & Martin Beye
Nature Communications 14, 463
Research | 27 January 2023

DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis
- Ye Wu
- , Yuting Chen
- & Faming Pan
Genes & Immunity, 1-6
Reviews | 27 January 2023

Pharmacogenomics: current status and future perspectives

In this Review, Munir Pirmohamed provides an overview of the current state of the pharmacogenomics field, using examples of clinically relevant drug–gene associations, before outlining the steps needed for implementation of pharmacogenomics into clinical practice. The role of pharmacogenomics in drug discovery and development is also considered.
- Munir Pirmohamed
Nature Reviews Genetics, 1-13
Research
27 January 2023 | Open Access

Human profiling from STR and SNP analysis of tropical bed bug, Cimex hemipterus, for forensic science
- Li Lim
- & Abdul Hafiz Ab Majid
Scientific Reports 13, 1506
Protocols | 27 January 2023

Measuring DNA modifications with the comet assay: a compendium of protocols

The comet assay is commonly used to assess DNA damage. This collection of consensus protocols includes adaptations for a wide range of species and sample types, assay formats and detection of different types of DNA lesions.
- Andrew Collins
- , Peter Møller
- & Amaya Azqueta
Nature Protocols, 1-61

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News and Comment

Comments & Opinion
28 January 2023 | Open Access

Sharing GWAS summary statistics results in more citations

A review of citation rates from genomic studies in the GWAS Catalog suggests that sharing summary statistics results, on average, in ~81.8% more citations, highlighting a benefit of publicly sharing GWAS summary statistics.
- Guillermo Reales
- & Chris Wallace
Communications Biology 6, 116
News | 25 January 2023

The race to supercharge cancer-fighting T cells

With a slew of tools to trick out immune cells, researchers are expanding the repertoire of CAR-T therapies.
- Heidi Ledford
Nature 613, 626-628
Correspondence | 24 January 2023

Early insight into spontaneous mutations
- Richard P. Novick
Nature 613, 629
Comments & Opinion
24 January 2023 | Open Access

An encounter with the mild side of LARS2-associated Perrault syndrome and its implications on the diagnostic odyssey
- Barbara Vona
European Journal of Human Genetics, 1-2
News | 24 January 2023

The next worrisome coronavirus variant could come from China — will it get detected?

Genomic surveillance is crucial for tracking the next ‘variant of concern’, but many countries are winding back their monitoring.
- Dyani Lewis
Nature
Research Highlights | 23 January 2023

Topical gene therapy relieves rare skin disorder

A gene-therapy treatment applied to the skin resulted in dramatic wound healing in patients with epidermolysis bullosa, a painful and debilitating skin condition.
- Karen O’Leary
Nature Medicine

All News & Comment

Genetics

Featured

The role of the genome regulatory network in heart failure

Fast-evolving genomic regions underlie human brain development

Chilling stress and loss of an exonuclease lead to biparental inheritance of plastids

Latest Research and Reviews

Maternal diet induces persistent DNA methylation changes in the muscle of beef calves

The function and evolution of a genetic switch controlling sexually dimorphic eye differentiation in honeybees

DNA methylation and transcriptome signatures of the PDCD1 gene in ankylosing spondylitis

Pharmacogenomics: current status and future perspectives

Human profiling from STR and SNP analysis of tropical bed bug, Cimex hemipterus, for forensic science

Measuring DNA modifications with the comet assay: a compendium of protocols

News and Comment

Sharing GWAS summary statistics results in more citations

The race to supercharge cancer-fighting T cells

Early insight into spontaneous mutations

An encounter with the mild side of LARS2-associated Perrault syndrome and its implications on the diagnostic odyssey

The next worrisome coronavirus variant could come from China — will it get detected?

Topical gene therapy relieves rare skin disorder

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Genetics

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