The replicational age of single cells provides a temporal reference for tracking cell fate transition trajectories. The computational framework EpiTrace measures cell age using single-cell ATAC-seq data, specifically by considering chromatin accessibility at clock-like genomic loci, enabling the reconstruction of the history of developmental and pathological processes.
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References
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This is a summary of: Xiao, Y. et al. Tracking single-cell evolution using clock-like chromatin accessibility loci. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02241-z (2024).
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Decoding cell replicational age from single-cell ATAC-seq data. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02256-6
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DOI: https://doi.org/10.1038/s41587-024-02256-6
