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Original Article
| Open AccessBCR–ABL1-induced downregulation of WASP in chronic myeloid leukemia involves epigenetic modification and contributes to malignancy
- Welbert O Pereira
- , Daniel D De Carvalho
- & Gustavo P Amarante-Mendes
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Original Article
| Open AccessExecutioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine
- Mark A Miles
- & Christine J Hawkins
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Original Article
| Open AccessAdropin deficiency worsens HFD-induced metabolic defects
- Shi Chen
- , Kai Zeng
- & Feng Gao
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Original Article
| Open AccessInefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells
- Pilar Alonso-Lecue
- , Isabel de Pedro
- & Alberto Gandarillas
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Original Article
| Open AccessThe NF-κB1 is a key regulator of acute but not chronic renal injury
- Amy Fearn
- , Gerhard R Situmorang
- & Neil S Sheerin
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Original Article
| Open AccessConcomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
- Tinka Haydn
- , Eric Metzger
- & Simone Fulda
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Original Article
| Open AccessIn vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects
- Tongmeng Jiang
- , Guojie Xu
- & Xingdong Zhang
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Review
| Open AccessHepatocyte polyploidization and its association with pathophysiological processes
- Min-Jun Wang
- , Fei Chen
- & Yi-Ping Hu
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Original Article
| Open AccessHeterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations
- Joel Fulton
- , Bismoy Mazumder
- & David M Heery
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Original Article
| Open Accessp53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo
- Evguenia M Alexandrova
- , Safia A Mirza
- & Ute M Moll
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Original Article
| Open AccessCALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis
- Qi-cai Liu
- , Falin Chen
- & Xin-hua Lin
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Original Article
| Open AccessSensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
- José Antonio Bejarano-García
- , África Millán-Uclés
- & José I Piruat
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Original Article
| Open AccessCysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation
- Álvaro de Mingo
- , Estefanía de Gregorio
- & Montserrat Marí
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Original Article
| Open AccessCnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes
- Mauro S Porcel de Peralta
- , Valeria S Mouguelar
- & Nora B Calcaterra
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Original Article
| Open AccessAttenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model
- Kit I Tong
- , Kazushige Ota
- & Hitoshi Okada
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Original Article
| Open AccessPosttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response
- Akhilesh Kumar
- , Michael D Birnbaum
- & Fangliang Zhang
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Original Article
| Open AccessmiR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways
- Zhi Hong Fang
- , Si Li Wang
- & Bing Xu
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Original Article
| Open AccessDistal regulation of c-myb expression during IL-6-induced differentiation in murine myeloid progenitor M1 cells
- Junfang Zhang
- , Bingshe Han
- & Linda Wolff
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Original Article
| Open AccessInhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents
- Olaf Klingbeil
- , Ralf Lesche
- & Pascale Lejeune
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Original Article
| Open AccessOncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
- Jin-Kwan Lee
- , Janet Lee
- & Chang-Woo Lee
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Original Article
| Open AccessMitochondrial dysfunction in an Opa1Q285STOP mouse model of dominant optic atrophy results from Opa1 haploinsufficiency
- Y Kushnareva
- , Y Seong
- & D D Newmeyer
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Original Article
| Open AccessDNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity
- Y Wang
- , H Sun
- & T Zhu
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Review
| Open AccessATP2C1 gene mutations in Hailey–Hailey disease and possible roles of SPCA1 isoforms in membrane trafficking
- M Micaroni
- , G Giacchetti
- & L Federici
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Original Article
| Open AccessPAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma
- J A Hanna
- , M R Garcia
- & M E Hatley
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Original Article
| Open AccessCardiac mesenchymal progenitors differentiate into adipocytes via Klf4 and c-Myc
- D Kami
- , T Kitani
- & S Gojo
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Original Article
| Open AccessParp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease
- S Lehmann
- , A C Costa
- & L M Martins
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Original Article |
p53MutaGene: an online tool to estimate the effect of p53 mutational status on gene regulation in cancer
- I Amelio
- , R A Knight
- & A V Antonov
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Meeting Report
| Open AccessThe 7th Barossa Meeting—Cell Signalling in Cancer Biology and Therapy in Barossa Valley, Australia
- M A Grimbaldeston
- , V M Dixit
- & M S Samuel
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News and Commentary
| Open AccessGenetic profiling of CLL: a ‘TP53 addict’ perspective
- L Lodé
- , F Cymbalista
- & T Soussi
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Original Article
| Open AccessPrediction of disease–gene–drug relationships following a differential network analysis
- S Zickenrott
- , V E Angarica
- & A del Sol
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Correspondence
| Open AccessOCGene: a database of experimentally verified ovarian cancer-related genes with precomputed regulation information
- Y Liu
- , J Xia
- & M Zhao
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Original Article
| Open AccessC2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro
- R Stanzione
- , S Sciarretta
- & S Rubattu
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Original Article
| Open AccessCigarette toxicity triggers Leber’s hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways
- L Giordano
- , S Deceglie
- & P Cantatore
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Original Article
| Open AccessTonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes
- Y J Yang
- , Y Y Han
- & J Zuo
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Original Article
| Open AccessElevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
- L M A Oliveira
- , L J Falomir-Lockhart
- & T M Jovin
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Original Article
| Open AccessThe point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury
- H Liu
- , W Li
- & S H Graham
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Original Article
| Open AccessPur-alpha functionally interacts with FUS carrying ALS-associated mutations
- M Di Salvio
- , V Piccinni
- & G Cestra
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Correspondence
| Open AccessIntrinsic hypoxia sensitivity of the cytomegalovirus promoter
- K Wendland
- , M Thielke
- & P Mergenthaler
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Original Article
| Open AccessIMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype
- S M Kessler
- , S Laggai
- & A K Kiemer
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Original Article
| Open AccessBAC transgenic mice provide evidence that p53 expression is highly regulated in vivo
- L Chen
- , G X Zhang
- & G Liu
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Original Article
| Open AccessInhibition of autophagy in EBV-positive Burkitt’s lymphoma cells enhances EBV lytic genes expression and replication
- A De Leo
- , F Colavita
- & E Mattia
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Original Article
| Open AccessMicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression
- J-J Jiang
- , C-M Liu
- & F-Q Zhou
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Original Article
| Open AccessA novel lncRNA, LUADT1, promotes lung adenocarcinoma proliferation via the epigenetic suppression of p27
- M Qiu
- , Y Xu
- & L Xu
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Original Article
| Open AccessSeipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility
- A E El Zowalaty
- , C Baumann
- & X Ye
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Original Article
| Open AccessTet3 mediates stable glucocorticoid-induced alterations in DNA methylation and Dnmt3a/Dkk1 expression in neural progenitors
- R Bose
- , S Spulber
- & S Ceccatelli
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Original Article
| Open AccessUbiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
- K Kluckova
- , M Sticha
- & J Rohlena
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Original Article
| Open AccessThe canonical Wg signaling modulates Bsk-mediated cell death in Drosophila
- S Zhang
- , C Chen
- & L Xue
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Original Article
| Open AccessReduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs
- H Mei
- , S Sun
- & H Li
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Original Article
| Open AccessD-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH
- K Oizel
- , C Gratas
- & C Pecqueur
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