Gene therapy articles within Nature Materials

Featured

  • Review Article |

    RNA-based therapeutics hold promise for the treatment of several diseases. This Review provides an overview of hydrogels for RNA delivery, discussing how the chemical nature and physical properties of hydrogels can be explored for tailored RNA loading and release, and highlighting the use of these materials in biomedical applications.

    • Ruibo Zhong
    • , Sepehr Talebian
    •  & Jinjun Shi

  • News & Views |

    Ionizable phospholipids have been developed to enhance the delivery of mRNA and sgRNA for gene editing by selective organ targeting and endosomal membrane destabilization.

    • Satish G. Jadhav
    •  & Steven F. Dowdy

  • News & Views |

    Hematopoietic stem and progenitor cells have been engineered using gold nanoformulations conjugated with CRISPR capable of targeting two distinct genomic loci of therapeutic interest, with potential engraftment in humanized mouse models.

    • Aravind Asokan

  • Commentary |

    The preclinical intersection of molecular imaging and gene- and cell-based therapies will enable more informed and effective clinical translation. We discuss how imaging can monitor cell and gene fate and function in vivo and overcome barriers associated with these therapies.

    • Nigel G. Kooreman
    • , Julia D. Ransohoff
    •  & Joseph C. Wu

Browse broader subjects

Browse narrower subjects

Browse Gene therapy across other nature.com journals