Biologics articles within Nature Materials

Featured

  • Editorial |

    The fundamental discoveries that enabled the development of effective mRNA vaccines against COVID-19 were awarded with this year’s Nobel Prize in Medicine.

  • Feature |

    Camille M. Le Gall, Jorieke Weiden, Loek J. Eggermont and Carl G. Figdor provide an overview of immunotherapeutics for cancer treatment that harness dendritic cells, their challenges in clinical use, and approaches employed to enhance their recruitment and activation to promote effective anti-tumour immunity.

    • Camille M. Le Gall
    • , Jorieke Weiden
    •  & Carl G. Figdor

  • Editorial |

    As the interaction of the immune system with the tumour microenvironment becomes increasingly understood, more evidence indicates how immunotherapy can be employed to better eliminate cancers.

  • Article |

    Microneedle arrays coated with a pH-sensitive releasable layer act as an intradermal delivery system for polyelectrolyte films containing bioactive molecules for DNA vaccination. The implanted films co-deliver DNA, transfection agents and adjuvants, promoting local transfection and generating immune responses that can be tuned from days to weeks.

    • Peter C. DeMuth
    • , Younjin Min
    •  & Darrell J. Irvine

  • Letter |

    The oral delivery of small interfering RNA (siRNA) to diseased intestinal tissue is challenging because of the harsh environment created by gastrointestinal fluids and mucosa. Now, such delivery of siRNA to sites of intestinal inflammation is achieved using polythioketal nanoparticles and gene expression is successfully inhibited in the inflamed tissue.

    • D. Scott Wilson
    • , Guillaume Dalmasso
    •  & Niren Murthy

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