Featured
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Article |
Generation of a live attenuated influenza A vaccine by proteolysis targeting
Influenza virus is attenuated for vaccine production using PROTAC degradation technology.
- Longlong Si
- , Quan Shen
- & Roberto Plebani
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Correspondence |
Tracking cell lineages to improve research reproducibility
- Sophie Zaaijer
- , Simon C. Groen
- & Neville E. Sanjana
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Letter |
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer
Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation.
- Kevin P O'Rourke
- , Evangelia Loizou
- & Scott W Lowe
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Brief Communication |
Highly efficient RNA-guided base editing in mouse embryos
Mice with targeted point mutations are generated efficiently using Cas9–cytidine deaminase fusions.
- Kyoungmi Kim
- , Seuk-Min Ryu
- & Jin-Soo Kim
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Article |
Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq
Oncogenic driver mutations are identified in single cells by a transposon-based sequencing method.
- Karen M Mann
- , Justin Y Newberg
- & Michael B Mann
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Correspondence |
Generation of knockout mice by Cpf1-mediated gene targeting
- Yongsub Kim
- , Seung-A Cheong
- & Young Hoon Sung
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News & Views |
Putting cells in their place
A combination of single-cell transcriptomics with in situ hybridization information enables single cells to be positioned within their tissue.
- Omid R Faridani
- & Rickard Sandberg
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News & Views |
Engineering insect-free cereals
A cluster of three rice lectin receptor kinases confers resistance to planthopper insects.
- Saskia A Hogenhout
- & Cyril Zipfel
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Letter |
Inducible in vivo genome editing with CRISPR-Cas9
Mouse lines with an inducible Cas9 gene enable in vivo disease modeling.
- Lukas E Dow
- , Jonathan Fisher
- & Scott W Lowe
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News & Views |
New models of human immunity
Two humanized mouse models open up a plethora of research applications.
- Hergen Spits
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News & Views |
Two views on light sheets
A dual-view light-sheet microscope combines isotropic spatial resolution with high speed and minimal phototoxicity.
- Carl G Ebeling
- & Erik M Jorgensen
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Article |
Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy
A dual-view light sheet microscope allows high-speed imaging with an isotropic spatial resolution
- Yicong Wu
- , Peter Wawrzusin
- & Hari Shroff
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Feature |
Recapitulating human cancer in a mouse
A panel of experts discusses the challenge of translating findings from current mouse models to the clinic.
- Lynda Chin
- , Frederic de Sauvage
- & William Weiss
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Editorial |
Laying better plans for mice
Genetically defined germ-free animal models colonized with defined microbiota are crucial for progress in microbiome research.
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Article
| Open Access
Genome sequence of the model mushroom Schizophyllum commune
Much remains to be learned about the biology of mushrooms, which are an important source of food as well as secondary metabolites and enzymes of biotechnological importance. Ohm et al. report the sequence of the genetically tractable species Schizophyllum commune and identify genes involved in the formation of fruiting bodies and the degradation of lignocellulose.
- Robin A Ohm
- , Jan F de Jong
- & Han A B Wösten
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News & Views |
Systematic phenotyping of mouse mutants
Comprehensive phenotypic screening of knockout mice highlights the pleiotropic functions of secreted and transmembrane proteins.
- Wolfgang Wurst
- & Martin Hrabe de Angelis
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News & Views |
Raising the bar for cancer therapy models
Can mouse cancer models predict the results of phase 3 clinical trials?
- Giulio Francia
- & Robert S Kerbel
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Resource |
Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
Genome-wide single-gene deletion libraries can be important tools for understanding the molecular workings of an organism, but have only been created for a single eukaryotic species, Saccharomyces cerevisiae. Now, Kim et al. present a second collection of deletion mutants that covers 98.4% of the genes of Schizosaccharomyces pombe, allowing a systematic comparison of gene essentiality and knockout phenotypes between two eukaryotic species.
- Dong-Uk Kim
- , Jacqueline Hayles
- & Kwang-Lae Hoe
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News & Views |
Haploidy with histones
An engineered centromere-specific histone could enable homozygous diploid lines to be generated at high frequency, simplifying crop breeding.
- Gregory P Copenhaver
- & Daphne Preuss
Breaking boundaries in whole-body imaging and disease understanding with wildDISCO
Hacking rules for E. coli
CRISPR mouse model boom, rat model renaissance
FDA approves 'farmaceutical' drug from transgenic chickens
Genomics separates the sheep from the goats
Lawsuits rock Jackson