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Systematic phenotyping of mouse mutants

Nature Biotechnology volume 28, pages 684–685 (2010)Cite this article

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Comprehensive phenotypic screening of knockout mice highlights the pleiotropic functions of secreted and transmembrane proteins.

Deciphering the functions of each mammalian gene is one of the most important challenges that the biomedical research community faces in the next few decades. Although advances in systematic mutagenesis technologies and phenotyping approaches now make it feasible to define physiological roles for all mammalian genes, determining all of the phenotypes associated with a single mutation will likely remain a major bottleneck for many years.

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Figure 1: The comprehensive screen performed by Tang et al.1 scored phenotypes of mice, each of which had one of 472 genes encoding membrane and secreted proteins knocked out, to reveal the involvement of the deleted gene in the function of different organ systems.

References

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  1. Wolfgang Wurst and Martin Hrabe de Angelis are at the Helmholtz Zentrum München, Munich/Neuherberg, Germany.

    Wolfgang Wurst & Martin Hrabe de Angelis

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  1. Wolfgang Wurst
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  2. Martin Hrabe de Angelis
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Correspondence to Wolfgang Wurst or Martin Hrabe de Angelis.

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The authors declare no competing financial interests.

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Wurst, W., de Angelis, M. Systematic phenotyping of mouse mutants. Nat Biotechnol 28, 684–685 (2010). https://doi.org/10.1038/nbt0710-684

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  • DOI: https://doi.org/10.1038/nbt0710-684

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