Endosomes articles within Nature Cell Biology

Featured

  • News & Views |

    Despite a growing understanding of the immunostimulatory properties of mitochondrial DNA (mtDNA), little is known about how and why mtDNA escapes its mitochondrial confines. A study now describes an endosomal trafficking pathway that facilitates mtDNA egress and provides an additional mechanism of mtDNA release in vitro.

    • Kate McArthur
    •  & Benjamin T. Kile

  • Comment |

    The extracellular vesicle (EV) surface corona is emerging as a crucial mediator of EV functions. This Comment discusses the roles and biogenesis of the EV corona, as well as the importance of controls to determine whether a biological effect is attributable to the internal EV cargo or to the corona associated with the EV exofacial surface.

    • Edit I. Buzas

  • Article
    | Open Access

    Zeziulia et al. identify the proton-activated Cl− channel ASOR/TMEM206 as necessary for shrinkage of macropinosomes, which is needed for downstream sorting events.

    • Mariia Zeziulia
    • , Sandy Blin
    •  & Thomas J. Jentsch

  • News & Views |

    In this issue of Nature Cell Biology, Mercier et al. show that acute changes in membrane tension may be a physiological trigger for ESCRT assembly, which drives membrane scission, luminal vesicle budding, and a wide array of other membrane remodelling events throughout the cell.

    • Robert C. Piper

  • News & Views |

    Endosomes are central stations for converging proteins from biosynthetic pathways and endocytic routes. Many endosomal proteins are sorted to the plasma membrane or the Golgi despite the lysosome being the primary endosomal fate. SNX5 and SNX6 are now revealed to decode a conserved bipartite signal to mediate protein sorting to the Golgi or the plasma membrane.

    • Wanjin Hong

  • News & Views |

    Membrane trafficking specificity between distinct compartments ensures that cargo proteins and lipids are delivered to their target organelle. However, accurate recognition of cargo carriers by tethering factors on target membranes is poorly understood. TBC1D23 is now identified as an adaptor that links endosome-derived vesicles with golgins at the trans-Golgi.

    • J. Christopher Fromme
    •  & Mary Munson

  • News & Views |

    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

    • Catherine Rabouille

  • News & Views |

    The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

    • Elena Rainero
    •  & Jim C. Norman

  • Article |

    Ivaska and colleagues report that endocytosed integrins are able to signal from endosomes in an FAK-dependent manner. They further show that endosomal integrin signalling can promote anoikis resistance and lung colonization in cancer cells.

    • Jonna Alanko
    • , Anja Mai
    •  & Johanna Ivaska

  • News & Views |

    How proteins migrate through the interconnected organelles of the endolysosomal system is poorly understood. A piece of the puzzle has been added with the identification of a complex of tethering factors that functions in the recycling of proteins towards the cell surface.

    • Yann Desfougères
    • , Massimo D'Agostino
    •  & Andreas Mayer

  • Article |

    Bonifacino and colleagues identify a four-protein complex, called the endosome-associated recycling protein (EARP) complex, that associates with Rab4-positive endosomes and promotes recycling-endosome tethering and fusion.

    • Christina Schindler
    • , Yu Chen
    •  & Juan S. Bonifacino

  • Article |

    During cytokinesis, the intercellular bridge connecting the mother and daughter cell is thinned by a process called secondary ingression before it is eventually severed in an ESCRT-III-dependent manner. Prekeris and colleagues report that FIP3-positive endosomes deliver p50RhoGAP and SCAMP2/3 proteins to the intercellular bridge, which promote actin depolymerization to decrease the bridge diameter and allow ESCRT-III binding.

    • John A. Schiel
    • , Glenn C. Simon
    •  & Rytis Prekeris

  • Article |

    RAB-11-positive recycling endosomes participate in the establishment and maintenance of epithelial polarity. Zerial and colleagues carry out an in vivo image-based RNAi screen for factors that regulate recycling endosome positioning in Caenorhabditis elegans. They identify, among other candidates, PAR-5 as a key determinant of recycling endosome positioning and, thus, apicobasal polarity.

    • Julia Franziska Winter
    • , Sebastian Höpfner
    •  & Marino Zerial

  • Article |

    Integrin internalization through the endosomal pathway can lead either to recycling back to the surface or to lysosomal degradation. Faessler and colleagues now show that, following internalization, β1 integrins are bound by sorting nexin 17 in early endosomes to prevent integrin degradation in lysosomes and to promote surface recycling.

    • Ralph Thomas Böttcher
    • , Christopher Stremmel
    •  & Reinhard Fässler

  • Letter |

    Plants possess a unique repertoire of SNARE and RAB GTPase proteins that regulate membrane trafficking events. The plant-specific RAB protein ARA6 regulates the formation of a specific SNARE complex to modulate the response to environmental cues.

    • Kazuo Ebine
    • , Masaru Fujimoto
    •  & Takashi Ueda

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