Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.
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Thanks to A. M. Escobar and W. van Leeuwen for critically reading the manuscript.
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Rabouille, C. Retriever fetches integrins from endosomes. Nat Cell Biol 19, 1144–1146 (2017). https://doi.org/10.1038/ncb3612
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DOI: https://doi.org/10.1038/ncb3612
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