Developmental biology

  • Article
    | Open Access

    During development, oriented cell division is important to proper body axis extension. Here, the authors show that sphingolipids are required to direct spindle rotation and oriented mitosis via Anthrax receptor palmitoylation in zebrafish gastrulation.

    • I. Castanon
    • , J. T. Hannich
    • , L. Abrami
    • , F. Huber
    • , M. Dubois
    • , M. Müller
    • , F. G. van der Goot
    •  & M. Gonzalez-Gaitan
  • Article
    | Open Access

    Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.

    • Tadatoshi Sato
    • , Shiv Verma
    • , Christian D. Castro Andrade
    • , Maureen Omeara
    • , Nia Campbell
    • , Jialiang S. Wang
    • , Murat Cetinbas
    • , Audrey Lang
    • , Brandon J. Ausk
    • , Daniel J. Brooks
    • , Ruslan I. Sadreyev
    • , Henry M. Kronenberg
    • , David Lagares
    • , Yuhei Uda
    • , Paola Divieti Pajevic
    • , Mary L. Bouxsein
    • , Ted S. Gross
    •  & Marc N. Wein
  • Article
    | Open Access

    The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine and exocrine function for up to ten days in culture.

    • Mirza Muhammad Fahd Qadir
    • , Silvia Álvarez-Cubela
    • , Jonathan Weitz
    • , Julia K. Panzer
    • , Dagmar Klein
    • , Yaisa Moreno-Hernández
    • , Sirlene Cechin
    • , Alejandro Tamayo
    • , Joana Almaça
    • , Helmut Hiller
    • , Maria Beery
    • , Irina Kusmartseva
    • , Mark Atkinson
    • , Stephan Speier
    • , Camillo Ricordi
    • , Alberto Pugliese
    • , Alejandro Caicedo
    • , Christopher A. Fraker
    • , Ricardo Luis Pastori
    •  & Juan Domínguez-Bendala
  • Article
    | Open Access

    Phenotypic robustness to environmental variation is seemingly at odds with evolvability. Here, the authors analyze carotenoid use and accommodation in feather development across a recent avian range expansion and show that cooption of a stress-buffering mechanism can reconcile robustness and evolvability.

    • Ahva L. Potticary
    • , Erin S. Morrison
    •  & Alexander V. Badyaev
  • Article
    | Open Access

    The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly.

    • Robert E. Turnbull
    • , Louise Fairall
    • , Almutasem Saleh
    • , Emma Kelsall
    • , Kyle L. Morris
    • , T. J. Ragan
    • , Christos G. Savva
    • , Aditya Chandru
    • , Christopher J. Millard
    • , Olga V. Makarova
    • , Corinne J. Smith
    • , Alan M. Roseman
    • , Andrew M. Fry
    • , Shaun M. Cowley
    •  & John W. R. Schwabe
  • Article
    | Open Access

    De novo DNA methylation is carried out by DNMT3A and DNMT3B, but the distinct functions of these two enzymes is poorly understood. Here the authors present a comprehensive, genome-wide identification of target sites for de novo DNA methylation by the DNMT3A and DNMT3B in mouse ES cells and embryos, identifying unique de novo DNA methylation target sites for both DNMT3 enzymes.

    • Masaki Yagi
    • , Mio Kabata
    • , Akito Tanaka
    • , Tomoyo Ukai
    • , Sho Ohta
    • , Kazuhiko Nakabayashi
    • , Masahito Shimizu
    • , Kenichiro Hata
    • , Alexander Meissner
    • , Takuya Yamamoto
    •  & Yasuhiro Yamada
  • Article
    | Open Access

    Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.

    • Eran Assaraf
    • , Ronen Blecher
    • , Lia Heinemann-Yerushalmi
    • , Sharon Krief
    • , Ron Carmel Vinestock
    • , Inbal E. Biton
    • , Vlad Brumfeld
    • , Ron Rotkopf
    • , Erez Avisar
    • , Gabriel Agar
    •  & Elazar Zelzer
  • Article
    | Open Access

    MicroRNA2118 induces the production of phased small interfering RNAs (phaisRNAs) in plants. Here the authors show that rice miR2118 is required for both male and female fertility and supports the production of atypical U-rich 21 nt phasiRNAs that are abundant in anther walls.

    • Saori Araki
    • , Ngoc Tu Le
    • , Koji Koizumi
    • , Alejandro Villar-Briones
    • , Ken-Ichi Nonomura
    • , Masaki Endo
    • , Haruhiko Inoue
    • , Hidetoshi Saze
    •  & Reina Komiya
  • Article
    | Open Access

    DNA methyltrasferases play important role during mouse embryo development. Here the authors reveal the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos genome-wide.

    • Thomas Dahlet
    • , Andrea Argüeso Lleida
    • , Hala Al Adhami
    • , Michael Dumas
    • , Ambre Bender
    • , Richard P. Ngondo
    • , Manon Tanguy
    • , Judith Vallet
    • , Ghislain Auclair
    • , Anaïs F. Bardet
    •  & Michael Weber
  • Article
    | Open Access

    Lineage tracing studies combining CRISPR-Cas9 editing and scRNA-seq face several challenges and cannot integrate lineages from multiple individuals. Here the authors show that integration of mutation and expression leads to accurate lineage tree inference and enables the learning of a species-invariant lineage tree.

    • Hamim Zafar
    • , Chieh Lin
    •  & Ziv Bar-Joseph
  • Article
    | Open Access

    ADNP has been connected to neural developmental disorders. Here, the authors uncover a role for ADNP in neural induction and differentiation via β-Catenin stabilization, with ADNP disruption in zebrafish leading to defective neurogenesis and decreased Wnt signaling.

    • Xiaoyun Sun
    • , Xixia Peng
    • , Yuqin Cao
    • , Yan Zhou
    •  & Yuhua Sun
  • Article
    | Open Access

    The mechanisms behind the plasticity of embryos and how they deal with aneuploid cells are unclear. Here, the authors show that aneuploid cells in a mouse embryo are preferentially eliminated during pre- and peri-implantation development in a p53-dependent process involving both autophagy and apoptosis.

    • Shruti Singla
    • , Lisa K. Iwamoto-Stohl
    • , Meng Zhu
    •  & Magdalena Zernicka-Goetz
  • Article
    | Open Access

    The discovery of hierarchies in biological processes is central to developmental biology. Here the authors propose Poincaré maps, a method based on hyperbolic geometry to discover continuous hierarchies from pairwise similarities.

    • Anna Klimovskaia
    • , David Lopez-Paz
    • , Léon Bottou
    •  & Maximilian Nickel
  • Article
    | Open Access

    Sequential generation of layer-specific cortical neurons requires radial glial cells (RGCs) to balance self-renewal and commitment. Here the authors show that RGCs and lineage committed progenitors are defined by distinct cell cycle phases and CYCLIN-B1/2 cooperates with CDK1 to activate Notch and maintain RGCs.

    • Daniel W. Hagey
    • , Danijal Topcic
    • , Nigel Kee
    • , Florie Reynaud
    • , Maria Bergsland
    • , Thomas Perlmann
    •  & Jonas Muhr
  • Article
    | Open Access

    Lymphatic malformation (LM) is a debilitating often incurable vascular disease. Using a mouse model of LM driven by a disease-causative PIK3CA mutation, the authors show that vascular growth is dependent on the upstream lymphangiogenic VEGF-C signalling, permitting effective therapeutic intervention.

    • Ines Martinez-Corral
    • , Yan Zhang
    • , Milena Petkova
    • , Henrik Ortsäter
    • , Sofie Sjöberg
    • , Sandra D. Castillo
    • , Pascal Brouillard
    • , Louis Libbrecht
    • , Dieter Saur
    • , Mariona Graupera
    • , Kari Alitalo
    • , Laurence Boon
    • , Miikka Vikkula
    •  & Taija Mäkinen
  • Article
    | Open Access

    Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distribution in zebrafish

    • Nellie Y. Loh
    • , James E. N. Minchin
    • , Katherine E. Pinnick
    • , Manu Verma
    • , Marijana Todorčević
    • , Nathan Denton
    • , Julia El-Sayed Moustafa
    • , John P. Kemp
    • , Celia L. Gregson
    • , David M. Evans
    • , Matt J. Neville
    • , Kerrin S. Small
    • , Mark I. McCarthy
    • , Anubha Mahajan
    • , John F. Rawls
    • , Fredrik Karpe
    •  & Constantinos Christodoulides
  • Article
    | Open Access

    The signals restricting specification of vascular progenitors are unclear. Here, the authors use scRNAseq to identify transitional steps during blood and vascular development in zebrafish and identify Etv2 as repressing skeletal muscle differentiation in vascular progenitors.

    • Brendan Chestnut
    • , Satish Casie Chetty
    • , Andrew L. Koenig
    •  & Saulius Sumanas
  • Article
    | Open Access

    The transcriptional repressor Blimp1/PRDM1 regulates cell fate decisions in the developing embryo and adult tissues. Here the authors show that conditional inactivation within maternal uterine tissues results in a defective primary decidual zone barrier, increased expression of inflammatory cytokines IFN gamma and Csf1, and early embryonic lethality during pregnancy.

    • Mubeen Goolam
    • , Maria-Eleni Xypolita
    • , Ita Costello
    • , John P. Lydon
    • , Francesco J. DeMayo
    • , Elizabeth K. Bikoff
    • , Elizabeth J. Robertson
    •  & Arne W. Mould
  • Article
    | Open Access

    Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic development relating to metabolic diseases such as type 2 diabetes.

    • Amar M. Singh
    • , Liang Zhang
    • , John Avery
    • , Amelia Yin
    • , Yuhong Du
    • , Hui Wang
    • , Zibo Li
    • , Haian Fu
    • , Hang Yin
    •  & Stephen Dalton
  • Article
    | Open Access

    The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.

    • Ronan Russell
    • , Phichitpol P. Carnese
    • , Thomas G. Hennings
    • , Emily M. Walker
    • , Holger A. Russ
    • , Jennifer S. Liu
    • , Simone Giacometti
    • , Roland Stein
    •  & Matthias Hebrok
  • Article
    | Open Access

    The teleost Astyanax mexicanus has sighted morphs living in surface rivers and various blind morphs living in caves. Here, the authors suggest that loss of eyes in cave morphs is linked to mutations in the cystathionine ß-synthase a (cbsa) gene, which cause eye degeneration by disrupting function of the optic circulatory system.

    • Li Ma
    • , Aniket V. Gore
    • , Daniel Castranova
    • , Janet Shi
    • , Mandy Ng
    • , Kelly A. Tomins
    • , Corine M. van der Weele
    • , Brant M. Weinstein
    •  & William R. Jeffery
  • Article
    | Open Access

    B chromosomes are supernumerary chromosomes exhibiting dramatic differences between different organs in same species. Here, the authors show programmed B chromosome elimination in goatgrass starts at the onset of embryo differentiation by nondisjunction of chromatids, anaphase lagging, and ends with the degradation of micronucleated DNA.

    • Alevtina Ruban
    • , Thomas Schmutzer
    • , Dan D. Wu
    • , Joerg Fuchs
    • , Anastassia Boudichevskaia
    • , Myroslava Rubtsova
    • , Klaus Pistrick
    • , Michael Melzer
    • , Axel Himmelbach
    • , Veit Schubert
    • , Uwe Scholz
    •  & Andreas Houben
  • Article
    | Open Access

    How and where VEGF-C is processed in lymphangiogenesis is unclear. Here, the authors show that development of the zebrafish lymphatic system is locally restricted by Vegfc maturation causing lymphatic sprouting in certain regions, which is regulated by the metalloproteases ADAMTS3 and ADAMTS14.

    • Guangxia Wang
    • , Lars Muhl
    • , Yvonne Padberg
    • , Laura Dupont
    • , Josi Peterson-Maduro
    • , Martin Stehling
    • , Ferdinand le Noble
    • , Alain Colige
    • , Christer Betsholtz
    • , Stefan Schulte-Merker
    •  & Andreas van Impel
  • Article
    | Open Access

    Long noncoding RNA SAM (Sugt1 associated muscle) is upregulated in the proliferating myoblast cells. Here the authors investigate SAM knockout mice and suggest that SAM binds and stabilizes Sugt1, a co-chaperone protein that regulates kinetochore assembly.

    • Yuying Li
    • , Jie Yuan
    • , Fengyuan Chen
    • , Suyang Zhang
    • , Yu Zhao
    • , Xiaona Chen
    • , Leina Lu
    • , Liang Zhou
    • , Ching Yan Chu
    • , Hao Sun
    •  & Huating Wang
  • Article
    | Open Access

    Identification of genes that determine and regulate cell identity remains challenging. Here, the authors use machine learning to identify cell identity genes and master regulator transcription factors based on gene expression profiles and histone modifications.

    • Bo Xia
    • , Dongyu Zhao
    • , Guangyu Wang
    • , Min Zhang
    • , Jie Lv
    • , Alin S. Tomoiaga
    • , Yanqiang Li
    • , Xin Wang
    • , Shu Meng
    • , John P. Cooke
    • , Qi Cao
    • , Lili Zhang
    •  & Kaifu Chen
  • Article
    | Open Access

    If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that eliminates Dmc1−/− and Msh5−/− oocytes.

    • Elias ElInati
    • , Agata P. Zielinska
    • , Afshan McCarthy
    • , Nada Kubikova
    • , Valdone Maciulyte
    • , Shantha Mahadevaiah
    • , Mahesh N. Sangrithi
    • , Obah Ojarikre
    • , Dagan Wells
    • , Kathy K. Niakan
    • , Melina Schuh
    •  & James M. A. Turner
  • Article
    | Open Access

    Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.

    • Michal Lipinski
    • , Rafael Muñoz-Viana
    • , Beatriz del Blanco
    • , Angel Marquez-Galera
    • , Juan Medrano-Relinque
    • , José M. Caramés
    • , Andrzej A. Szczepankiewicz
    • , Jordi Fernandez-Albert
    • , Carmen M. Navarrón
    • , Roman Olivares
    • , Grzegorz M. Wilczyński
    • , Santiago Canals
    • , Jose P. Lopez-Atalaya
    •  & Angel Barco
  • Article
    | Open Access

    How cardiomyocytes mature and what regulates this is unclear. Here, the authors use single-cell analysis to examine how the population of murine cardiac fibroblasts changes during development and affects maturation of cardiomyocytes.

    • Yin Wang
    • , Fang Yao
    • , Lipeng Wang
    • , Zheng Li
    • , Zongna Ren
    • , Dandan Li
    • , Mingzhi Zhang
    • , Leng Han
    • , Shi-qiang Wang
    • , Bingying Zhou
    •  & Li Wang
  • Article
    | Open Access

    The consequences of postnatal Zika infection are not fully understood. Here, the authors show that postnatal Zika infection in infant rhesus macaques alters neurodevelopment resulting in social, cognitive and motor impairments, as well as structural and functional changes in the brain.

    • Jessica Raper
    • , Zsofia Kovacs-Balint
    • , Maud Mavigner
    • , Sanjeev Gumber
    • , Mark W. Burke
    • , Jakob Habib
    • , Cameron Mattingly
    • , Damien Fair
    • , Eric Earl
    • , Eric Feczko
    • , Martin Styner
    • , Sherrie M. Jean
    • , Joyce K. Cohen
    • , Mehul S. Suthar
    • , Mar M. Sanchez
    • , Maria C. Alvarado
    •  & Ann Chahroudi
  • Article
    | Open Access

    Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.

    • Ines Desanlis
    • , Yacine Kherdjemil
    • , Alexandre Mayran
    • , Yasser Bouklouch
    • , Claudia Gentile
    • , Rushikesh Sheth
    • , Rolf Zeller
    • , Jacques Drouin
    •  & Marie Kmita
  • Article
    | Open Access

    The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon injury.

    • Nunzia Pastore
    • , Tuong Huynh
    • , Niculin J. Herz
    • , Alessia Calcagni’
    • , Tiemo J. Klisch
    • , Lorenzo Brunetti
    • , Kangho Ho Kim
    • , Marco De Giorgi
    • , Ayrea Hurley
    • , Annamaria Carissimo
    • , Margherita Mutarelli
    • , Niya Aleksieva
    • , Luca D’Orsi
    • , William R. Lagor
    • , David D. Moore
    • , Carmine Settembre
    • , Milton J. Finegold
    • , Stuart J. Forbes
    •  & Andrea Ballabio
  • Article
    | Open Access

    The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.

    • Tongyu Liu
    • , Lin Mi
    • , Jing Xiong
    • , Peter Orchard
    • , Qi Yu
    • , Lei Yu
    • , Xu-Yun Zhao
    • , Zhuo-Xian Meng
    • , Stephen C. J. Parker
    • , Jiandie D. Lin
    •  & Siming Li
  • Article
    | Open Access

    YAP1 gene fusions are found in subgroups of paediatric ependymomas. Here the authors show that YAP1 activation in NeuroD6 positive neuronal precursor cells can induce ependymoma-like tumours in mice.

    • Noreen Eder
    • , Federico Roncaroli
    • , Marie-Charlotte Dolmart
    • , Stuart Horswell
    • , Felipe Andreiuolo
    • , Helen R. Flynn
    • , Andre T. Lopes
    • , Suzanne Claxton
    • , John-Paul Kilday
    • , Lucy Collinson
    • , Jun-Hao Mao
    • , Torsten Pietsch
    • , Barry Thompson
    • , Ambrosius P. Snijders
    •  & Sila K. Ultanir
  • Article
    | Open Access

    How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.

    • Likhitha Kolla
    • , Michael C. Kelly
    • , Zoe F. Mann
    • , Alejandro Anaya-Rocha
    • , Kathryn Ellis
    • , Abigail Lemons
    • , Adam T. Palermo
    • , Kathy S. So
    • , Joseph C. Mays
    • , Joshua Orvis
    • , Joseph C. Burns
    • , Ronna Hertzano
    • , Elizabeth C. Driver
    •  & Matthew W. Kelley
  • Article
    | Open Access

    The downstream pathway regulating how TGF-beta affects pluripotency of human PSCs is unclear. Here, the authors find that transcription factor ZNF398 binds active promoters/enhancers together with the histone acetyltransferase EP300 and SMAD3, enabling expression of pluripotency and epithelial genes.

    • Irene Zorzan
    • , Marco Pellegrini
    • , Mattia Arboit
    • , Danny Incarnato
    • , Mara Maldotti
    • , Mattia Forcato
    • , Guidantonio Malagoli Tagliazucchi
    • , Elena Carbognin
    • , Marco Montagner
    • , Salvatore Oliviero
    •  & Graziano Martello
  • Article
    | Open Access

    Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.

    • Masaki Takasugi
    • , Denis Firsanov
    • , Gregory Tombline
    • , Hanbing Ning
    • , Julia Ablaeva
    • , Andrei Seluanov
    •  & Vera Gorbunova
  • Article
    | Open Access

    The evolutionarily conserved complex, the Par proteins, regulates cell polarity. Here, the authors show that in Drosophila neuroblasts, the Par complex exhibits liquid–liquid phase separation dependent on the cell cycle.

    • Ziheng Liu
    • , Ying Yang
    • , Aihong Gu
    • , Jiawen Xu
    • , Ying Mao
    • , Haojie Lu
    • , Weiguo Hu
    • , Qun-Ying Lei
    • , Zhouhua Li
    • , Mingjie Zhang
    • , Yu Cai
    •  & Wenyu Wen
  • Article
    | Open Access

    Runx2 is essential for tuning the generation of bone from skeletal stem cells (SSCs). Here, the authors demonstrate that the CK2/HAUSP pathway stabilizes RUNX2 protein thereby regulating the commitment of SSCs to osteoprogenitors as well as their subsequent maturation, and that inhibition of this pathway can block heterotopic ossification.

    • Jung-Min Kim
    • , Yeon-Suk Yang
    • , Kwang Hwan Park
    • , Xianpeng Ge
    • , Ren Xu
    • , Na Li
    • , Minkyung Song
    • , Hyunho Chun
    • , Seoyeon Bok
    • , Julia F. Charles
    • , Odile Filhol-Cochet
    • , Brigitte Boldyreff
    • , Teresa Dinter
    • , Paul B. Yu
    • , Ning Kon
    • , Wei Gu
    • , Takeshi Takarada
    • , Matthew B. Greenblatt
    •  & Jae-Hyuck Shim
  • Article
    | Open Access

    Cell competition among epithelial cells allows removal of unfit or dangerous cells. Here, the authors show that the NMDA receptor is an important determinant of cell fitness in the Drosophila wing, also in the context of Myc super-competitor cells, with “loser” cells contributing metabolitic fuel to “winner” cells.

    • Agnes R. Banreti
    •  & Pascal Meier
  • Article
    | Open Access

    Most cells possess sensory cilia, which need to be gated properly. Here the authors show that the C. elegans proteins TALP-3 and ANKR-26 coordinate cilia gating in the context of transition fibers and that this mechanism is conserved in mammalian cells and likely implicated in certain ciliopathies.

    • Hao Yan
    • , Chuan Chen
    • , Huicheng Chen
    • , Hui Hong
    • , Yan Huang
    • , Kun Ling
    • , Jinghua Hu
    •  & Qing Wei
  • Article
    | Open Access

    Somatic cell nuclear transfer (SCNT) frequently results in abnormal placenta development in cloned mice. Here the authors show that loss of histone methylation (H3K27me3) imprinting in clustered Sfmbt2 miRNAs contributes to SCNT placenta defect.

    • Kimiko Inoue
    • , Narumi Ogonuki
    • , Satoshi Kamimura
    • , Hiroki Inoue
    • , Shogo Matoba
    • , Michiko Hirose
    • , Arata Honda
    • , Kento Miura
    • , Masashi Hada
    • , Ayumi Hasegawa
    • , Naomi Watanabe
    • , Yukiko Dodo
    • , Keiji Mochida
    •  & Atsuo Ogura
  • Article
    | Open Access

    Endothelin-1 (ET-1) is a vasoconstrictor molecule that is also present in the developing and injured CNS. Here the authors show that ET-1 is present in the postnatal subventricular zone and acts to regulate maintenance and proliferation of radial glial cells and oligodendrocyte progenitor cells.

    • Katrina L. Adams
    • , Giulia Riparini
    • , Payal Banerjee
    • , Marjolein Breur
    • , Marianna Bugiani
    •  & Vittorio Gallo
  • Article
    | Open Access

    How epigenetic regulation affects pancreatic development is unclear. Here, the authors show that the histone demethylase LSD1 regulates the epigenetic state of developmental enhancers during pancreatic specification and controls how these enhancers respond to extracellular signals, namely retinoic acid.

    • Nicholas K. Vinckier
    • , Nisha A. Patel
    • , Ryan J. Geusz
    • , Allen Wang
    • , Jinzhao Wang
    • , Ileana Matta
    • , Austin R. Harrington
    • , Matthew Wortham
    • , Nichole Wetton
    • , Jianxun Wang
    • , Ulupi S. Jhala
    • , Michael G. Rosenfeld
    • , Christopher W. Benner
    • , Hung-Ping Shih
    •  & Maike Sander
  • Article
    | Open Access

    In the central nervous system, the maturation of glial cells is temporally and functionally coupled with that of the vascular network during postnatal development. Here the authors show that oligodendroglial HIFα regulates CNS angiogenesis through Wnt-independent and VEGF-dependent signaling, while astroglial HIFα participates through Wnt-dependent signaling.

    • Sheng Zhang
    • , Bokyung Kim
    • , Xiaoqing Zhu
    • , Xuehong Gui
    • , Yan Wang
    • , Zhaohui Lan
    • , Preeti Prabhu
    • , Kenneth Fond
    • , Aijun Wang
    •  & Fuzheng Guo
  • Article
    | Open Access

    Gene regulation and metabolism co-ordinate self-renewal and differentiation of neural precursors (NPCs) in the developing brain. Here the authors show that methylglyoxal, a glycolytic intermediate metabolite, promotes GADPH-dependent translational repression of Notch1, thereby promoting NPC differentiation.

    • Deivid Carvalho Rodrigues
    • , Emily M. Harvey
    • , Rejitha Suraj
    • , Sarah L. Erickson
    • , Lamees Mohammad
    • , Mengli Ren
    • , Hongrui Liu
    • , Guiqiong He
    • , David R. Kaplan
    • , James Ellis
    •  & Guang Yang
  • Article
    | Open Access

    Epithelial gene expression has been shown to be zonated along the crypt-villus axis, but mechanisms shaping this spatial variability were unknown. Here, Bahar Halpern et al. uncover zonation of mesenchymal cells, including Lgr5+ telocytes, which regulate epithelial gene expression at the villus tip.

    • Keren Bahar Halpern
    • , Hassan Massalha
    • , Rachel K. Zwick
    • , Andreas E. Moor
    • , David Castillo-Azofeifa
    • , Milena Rozenberg
    • , Lydia Farack
    • , Adi Egozi
    • , Dan R. Miller
    • , Inna Averbukh
    • , Yotam Harnik
    • , Noa Weinberg-Corem
    • , Frederic J. de Sauvage
    • , Ido Amit
    • , Ophir D. Klein
    • , Michal Shoshkes-Carmel
    •  & Shalev Itzkovitz
  • Article
    | Open Access

    Disruption of different components of molecular circadian clocks has varying effects on health and lifespan of model organisms. Here the authors show that loss of period extends life in drosophila melanogaster.

    • Matt Ulgherait
    • , Anna Chen
    • , Sophie F. McAllister
    • , Han X. Kim
    • , Rebecca Delventhal
    • , Charlotte R. Wayne
    • , Christian J. Garcia
    • , Yocelyn Recinos
    • , Miles Oliva
    • , Julie C. Canman
    • , Martin Picard
    • , Edward Owusu-Ansah
    •  & Mimi Shirasu-Hiza
  • Article
    | Open Access

    During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.

    • Anna Popkova
    • , Orrin J. Stone
    • , Lin Chen
    • , Xiang Qin
    • , Chang Liu
    • , Jiaying Liu
    • , Karine Belguise
    • , Denise J. Montell
    • , Klaus M. Hahn
    • , Matteo Rauzi
    •  & Xiaobo Wang