Cryoelectron microscopy articles within Nature

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  • Article |

    Cryo-electron microscopy of aggregated TDP-43 from postmortem brain tissue of individuals who had ALS with FTLD reveals a filament structure with distinct features to other neuropathological protein filaments, such as those of tau and α-synuclein.

    • Diana Arseni
    • , Masato Hasegawa
    •  & Benjamin Ryskeldi-Falcon

  • Article |

    Cryo-electron microscopy structures of the photosystem I–NADH dehydrogenase-like supercomplex in barley provide structural details to elucidate the functions and regulation of photosystem I-dependent cyclic electron transport in chloroplasts.

    • Liangliang Shen
    • , Kailu Tang
    •  & Xing Zhang

  • Article |

    Cryo-electron microscopy structures of the sodium–glucose cotransporter SGLT1 and a related transporter SMCT1 define the architecture of this protein family and provide insights into substrate binding and transport function.

    • Lei Han
    • , Qianhui Qu
    •  & Liang Feng

  • Article |

    Cryo-electron microscopy, nuclear magnetic resonance and X-ray crystallography are used to provide structural and mechanistic details of the activation of anaplastic lymphoma kinase by the ligands ALKAL1 and ALKAL2.

    • Andrey V. Reshetnyak
    • , Paolo Rossi
    •  & Charalampos G. Kalodimos

  • Article |

    Cryo-electron microscopy structures of the MRGPRX2–Gi1 trimer in complex with polycationic compound 48/80 or inflammatory peptides provide insights into the sensing of cationic allergens by MRGPRX2, potentially facilitating the design of therapies to prevent unwanted pseudoallergic reactions.

    • Fan Yang
    • , Lulu Guo
    •  & Jin-Peng Sun

  • Article |

    Structures of Ubr1 in complex with Ubc2, ubiquitin and two N-degron peptides reveal a Ubc2-binding region and an acceptor ubiquitin-binding loop on Ubr1, providing mechanistic insights into the initiation and elongation steps of ubiquitination catalysed by Ubr1.

    • Man Pan
    • , Qingyun Zheng
    •  & Minglei Zhao

  • Article |

    Cryo-electron microscopy studies show that dynamic coordination of Na+ in the ion channel of Dispatched homologue 1 and the transmembrane Na+ gradient have key roles in exporting lipid-modified Hedgehog protein signal.

    • Qianqian Wang
    • , Daniel E. Asarnow
    •  & Philip A. Beachy

  • Article
    | Open Access

    Cryo-EM structure of Nf1 protein is reported, revealing closed and open conformations that regulate interaction with Ras oncogene, setting the stage for understanding the mechanistic action of Nf1 and how disease mutations lead to dysfunction.

    • Andreas Naschberger
    • , Rozbeh Baradaran
    •  & Marta Carroni

  • Article |

    The cryo-electron microscopy structure of domain 1 of the LDLRAD3 receptor in complex with virus-like particles of Venezuelan equine encephalitis virus (VEEV) provides insights into the assembly and entry of VEEV and other alphaviruses.

    • Bingting Ma
    • , Cuiqing Huang
    •  & Xinzheng Zhang

  • Article |

    Cryo-electron microscopy structures of tau filaments from progressive supranuclear palsy and other tauopathies reveal new filament conformations, and suggest that tauopathies can be classified on several different levels according to their filament folds.

    • Yang Shi
    • , Wenjuan Zhang
    •  & Sjors H. W. Scheres

  • Article
    | Open Access

    Cryo-electron microscopy structures of the voltage-gated potassium channel Kv4.2 alone and in complex with auxiliary subunits (DPP6S and/or KChIP1) reveal the distinct mechanisms of these two different subunits in modulating channel activity.

    • Yoshiaki Kise
    • , Go Kasuya
    •  & Osamu Nureki

  • Article |

    Cryo-electron microscopy structures of the luteinizing hormone–choriogonadotropin receptor (LHCGR), in complex with Gs and in various states of activation, reveal a distinct mechanism of receptor activation, with implications for drug discovery.

    • Jia Duan
    • , Peiyu Xu
    •  & H. Eric Xu

  • Article |

    The authors report the structures of glutamate-gated kainate receptors in complex with NETO2 in both the resting and the desensitized states and reveal how kainate receptors in the brain are regulated by NETO2.

    • Lingli He
    • , Jiahui Sun
    •  & Yan Zhao

  • Article
    | Open Access

    The authors resolve the structure of five complexes containing RNA polymerase II and the CSA and CSB proteins, offering insight into how the repair of DNA lesions is coupled to transcription.

    • Goran Kokic
    • , Felix R. Wagner
    •  & Patrick Cramer

  • Article |

    MIPS521, a positive allosteric modulator of the adenosine A1 receptor, has analgesic properties in a rat model of neuropathic pain through a mechanism by which MIPS521 stabilizes the complex between adenosine, receptor and G protein.

    • Christopher J. Draper-Joyce
    • , Rebecca Bhola
    •  & Arthur Christopoulos

  • Article |

    Structural, functional and localization studies reveal that Geobacter sulfurreducens pili cannot behave as microbial nanowires, instead functioning in a similar way to secretion pseudopili to export cytochrome nanowires that are essential for extracellular electron transfer.

    • Yangqi Gu
    • , Vishok Srikanth
    •  & Nikhil S. Malvankar

  • Article |

    Cryo-electron microscopy structures of a PIWI–piRNA complex provide insight into how piRNAs recognise target RNAs and reveal differences from the target mechanisms of microRNAs.

    • Todd A. Anzelon
    • , Saikat Chowdhury
    •  & Ian J. MacRae

  • Article
    | Open Access

    The cryo-electron microscopy structure of a newly identified, early spliceosomal complex reveals the mechanism by which the RNA helicase Prp5 enhances the fidelity of the excision of introns from precursor mRNAs.

    • Zhenwei Zhang
    • , Norbert Rigo
    •  & Reinhard Lührmann

  • Article |

    Cryo-electron microscopy structures of human Cav2.2 in the presence or absence of ziconotide reveal the molecular basis of the specificity of this painkiller for Cav2.2, and provide insights into electromechanical coupling in Cav channels.

    • Shuai Gao
    • , Xia Yao
    •  & Nieng Yan

  • Article |

    A structure of the sperm-specific CatSper complex features a number of additional components; together, these components and the CatSper complex are termed the CatSpermasome.

    • Shiyi Lin
    • , Meng Ke
    •  & Jianping Wu

  • Article |

    Cryo-electron microscopy structures show that metabotropic glutamate receptor 2 forms a dimer to which only one G protein is coupled, revealing the basis for asymmetric signal transduction.

    • Alpay B. Seven
    • , Ximena Barros-Álvarez
    •  & Georgios Skiniotis

  • Article |

    Cryo-EM structures of human calcium-sensing receptor reveal intrinsic asymmetry in the receptor homodimer upon activation that is stabilized by calcimimetic drugs adopting distinct poses in the two protomers, priming one protomer for G-protein coupling.

    • Yang Gao
    • , Michael J. Robertson
    •  & Georgios Skiniotis

  • Article |

    Cryo-electron microscopy structures of homo- and heterodimers of mGlu2 and mGlu7 provide insights into their dimerization modes and the subunit conformational changes that characterize the activation of these class C G-protein-coupled receptors.

    • Juan Du
    • , Dejian Wang
    •  & Qiang Zhao

  • Article |

    Cryo-electron microscopy structures of PCFT in a substrate-free state and bound to the antifolate drug pemetrexed provide insights into how this protein recognizes folates and mediates their transport into cells.

    • Joanne L. Parker
    • , Justin C. Deme
    •  & Simon Newstead

  • Article
    | Open Access

    A cryo-electron microscopy structure of the inner membrane complex of the ESX-5 type VII secretion system of Mycobacterium tuberculosis reveals an important role of interactions with MycP5 protease for complex integrity.

    • Catalin M. Bunduc
    • , Dirk Fahrenkamp
    •  & Thomas C. Marlovits

  • Article |

    Analyses of hippocampal AMPA receptor–auxiliary subunit complexes provide insights into the predominant assemblies and organization of the AMPA receptor, TARP-γ8 and CNIH2/SynDIG4 and explain the mechanism of inhibition of a clinically relevant, brain-region-specific allosteric inhibitor.

    • Jie Yu
    • , Prashant Rao
    •  & Eric Gouaux

  • Article
    | Open Access

    Cryo-electron microscopy structure of heterodimeric GABAB receptor in complex with Gi1 protein reveals that the mode of G-protein binding in this class-C G-protein-coupled receptor differs from that of other classes.

    • Cangsong Shen
    • , Chunyou Mao
    •  & Jianfeng Liu

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